P-3074 (polichem Topical Finasteride) Phase Iii Just Ended.

[fuDHTck]

https://clinicaltrials.gov/ct2/show/NCT03004469?term=topical+finasteride&rank=3

Will be very interesting to see the results (and sides), especially against oral Finasteride.

 

[jamesbooker1975]

Who cares ? Old drug, will go systemic, will not give better results than combing cetirizine plus minoxidil, or minoxidil plus ketoconazole cream .
Real, a none sense. WE are in 2017 , Finasteride is available for prostate since 1992 . They took 26 years to develop this crap ? lol

 

[Rolandconil]

Who cares ? Old drug, will go systemic, will not give better results than combing cetirizine plus minoxidil, or minoxidil plus ketoconazole cream .
Real, a none sense. WE are in 2017 , Finasteride is available for prostate since 1992 . They took 26 years to develop this crap ? lol

frankly speaking, there is nothing on the horizon, except for brotzu. If the brotzu did not work, then the next 3 years we will stay on the big three.

 

[fuDHTck]

Who cares ? Old drug, will go systemic, will not give better results than combing cetirizine plus minoxidil, or minoxidil plus ketoconazole cream .
Real, a none sense. WE are in 2017 , Finasteride is available for prostate since 1992 . They took 26 years to develop this crap ? lol

Do you get a notification every time there is a topic about Finasteride so you can bash it?

Also your claims are retarded but I understand that it is impossible to discuss with someone like you.

 

[NorwoodGuardian]

frankly speaking, there is nothing on the horizon, except for brotzu. If the brotzu did not work, then the next 3 years we will stay on the big three.

No, I guess Shiseido 2019 and Follica 2020. Given that Shiseido and Follica are in the final trial, this is a realistic expectation.

 

[dralex]

Can we get this stuff somewhere? How long til a release most likely?

 

[d3nt3dsh0v3l]

frankly speaking, there is nothing on the horizon, except for brotzu. If the brotzu did not work, then the next 3 years we will stay on the big three.

What a ridiculous claim on so many levels.

First of all, everyone is prone to delays. Look no further than the title of the Brotzu thread to accept this reality.

Now, the prospect of delays aside, Brotzu, Shiseido and Follica are at approximately the same stage - final studies prior to product release.

And then there is the question of efficacy. One of these things is not like the other.
Hint: two of the players have published data in relevant journals, presented at international conferences, provided pictures of hair counts, biopsies, and other professional trichometrics, pursued strategies that have been verified by other researchers in the field to show the desired effect and demonstrated a great mechanistic understanding of the respective phenomenon they are trying to harness.

THE OTHER ONE has almost none of those qualifiers. Not sayings that it means the product is bunk, but lack of qualifiers is lack of qualifiers. I'm not going to get into professor reputation - all of the aforementioned companies have easy ties to reputable professors. I will not discuss the presence of patents or funding - all of the aforementioned players have IP and money because otherwise they have nothing.

How can you possibly claim with a clear mind that Brotzu is the front runner and not only that but the only legitimate candidate? Astonishingly incorrect.

 

[SimonC]

Who cares ? Old drug, will go systemic, will not give better results than combing cetirizine plus minoxidil, or minoxidil plus ketoconazole cream .
Real, a none sense. WE are in 2017 , Finasteride is available for prostate since 1992 . They took 26 years to develop this crap ? lol

Yes, it will probably go systemic, but it's also very possible that systemic absorption will be very small, as a result, it's fair to expect the significant reduction in side effects. The best case scenario is that most men will even not notice them.

Likely, guys who are very sensitive to oral finasteride still will have sides, but for many hair loss sufferers, topical finasteride should become a good option.

So, yeah, technically, it's still big 3, but if Polichem's topical Finasteride works fine, this combination will become a much better and efficient.

 

[jamesbooker1975]

Yes, it will probably go systemic, but it's also very possible that systemic absorption will be very small, as a result, it's fair to expect the significant reduction in side effects. The best case scenario is that most men will even not notice them.

Likely, guys who are very sensitive to oral finasteride still will have sides, but for many hair loss sufferers, topical finasteride should become a good option.

So, yeah, technically, it's still big 3, but if Polichem's topical Finasteride works fine, this combination will become a much better and efficient.

Again, Why go systemic if there are tons of better options ? Not even talk about future treatment like setipiprant , fevitiprant or breezula.
Even if is a minimal amount of what will goes systemic, we are talking about 250 mg every 100ml, by 2ml daily you will be applying 5mg daily ! . Lets say it have a minimal absorption of 5 % , which I doubt , it will be 0.25mg direct to the blood stream, nothing wasting on the stomach, that dose will give you side effects and will reduce your DHT almost as much as the 1mg dose.

Useless treatment, out of time, and even so, best scenario we will have to wait at least another year. A joke.

 

[jamesbooker1975]

Do you get a notification every time there is a topic about Finasteride so you can bash it?

Also your claims are retarded but I understand that it is impossible to discuss with someone like you.

Dude, What are your claims ? You are not even mention Prostaglandins !!!!!! Did you tried topical Cetirizine ?! Much, much better results than with just finasteride. You are that is f*****g his body with Finasteride , and you are treat me like I was the dumb here ? And what do you want ? more finasteride, lol.

 

[jamesbooker1975]

frankly speaking, there is nothing on the horizon, except for brotzu. If the brotzu did not work, then the next 3 years we will stay on the big three.

What the hell are you talking ? We have Brezzula in 3 years, setipiprant in 3 years and Fevipiprant in 2 years.
WE have Minoxidil, Alfa estradiol, Ketoconazole , Ceitrizine, topical spironolactone. Just with this old meds, you can keep your hair forever without side effects . Did you tried topical cetirizine ? oral drops 1% using to your scalp 2ml daily ? give it 4 month, then tell me
FInasteride is for ignorants.

 

[Vinc2097]

What the hell are you talking ? We have Brezzula in 3 years, setipiprant in 3 years and Fevipiprant in 2 years.
WE have Minoxidil, Alfa estradiol, Ketoconazole , Ceitrizine, topical spironolactone. Just with this old meds, you can keep your hair forever without side effects . Did you tried topical cetirizine ? oral drops 1% using to your scalp 2ml daily ? give it 4 month, then tell me
FInasteride is for ignorants.

What is alfa estradiol ? no sides ? is it topical or oral

 

[fuDHTck]

Dude, What are your claims ? You are not even mention Prostaglandins !!!!!! Did you tried topical Cetirizine ?! Much, much better results than with just finasteride. You are that is f*****g his body with Finasteride , and you are treat me like I was the dumb here ? And what do you want ? more finasteride, lol.

Well I thought you were crazy before and now I am sure about it after reading your last few messages.

 

[SimonC]

Not even talk about future treatment

Yeah, future treatments should be great. But they are 2-3 years from now, so having something better now is not so bad.

Not even talk about future treatment like setipiprant , fevitiprant or breezula.

I monitor Seti thread. It's very contradictory option because there is the only person who showed progress (maintenance) on Seti, other reviews are varied. Plus Seti is super expensive and you never know whether your next Chinese batch will be enough pure. I think we should wait till Allergan completes their research and then reconsider Seti.

Fevi should be better, but again we don't know for sure.

Breezula? It's topical anti-androgen, so in theory you can get Finasteride like sides.

Did you tried topical Cetirizine ?!

No. Can you provide any proofs (links to diaries) which show that topical Cetrizine is working?

P.S. I'm not Finasteride fan. Just trying to be a realist.

 

[Vinc2097]

Who cares ? Old drug, will go systemic, will not give better results than combing cetirizine plus minoxidil, or minoxidil plus ketoconazole cream .
Real, a none sense. WE are in 2017 , Finasteride is available for prostate since 1992 . They took 26 years to develop this crap ? lol

You are talking about mixing minoxidil with cetirizine, i am actually using cetirizine for now 2 weeks with no result (hair loss is even worse since 2 weeks)

I would like to had minoxidil in the mixture but a lot of people over internet say that alcohol with cetirizine is really bad for cetirizine activation

 

[dermrafok]

Yeah, future treatments should be great. But they are 2-3 years from now, so having something better now is not so bad.


I monitor Seti thread. It's very contradictory option because there is the only person who showed progress (maintenance) on Seti, other reviews are varied. Plus Seti is super expensive and you never know whether your next Chinese batch will be enough pure. I think we should wait till Allergan completes their research and then reconsider Seti.

Fevi should be better, but again we don't know for sure.

Breezula? It's topical anti-androgen, so in theory you can get Finasteride like sides.


No. Can you provide any proofs (links to diaries) which show that topical Cetrizine is working?

P.S. I'm not Finasteride fan. Just trying to be a realist.

Setipiprant will be a good alternative in the next years for those people who can not tolerate Finasteride.

 

[fuDHTck]

Although Setipiprant might be good it is only in phase 2/a.

Also there are so few people taking it and it's hard to tell how much it works. To be fair I am not impressed by westonci results.

 

[barfacan]

I still contend that in order for Finasteride to be effective it MUST go systemic. Thus efficacious topical finasteride treatments are a pipe dream.

In my nonexpert opinion of course.

 

[Johnt1997]

There' one thing I don't understand about the potential usefulness of topical finasteride: How does it work to maintain the hair all over your head if you only apply it to certain areas. I apply minoxidil to my crown and temples as these are thin spots, I have decent coverage elsewhere. With finasteride, if applied will it topically protect the whole head even if its only applied to hairless/thin areas?

 

[fuDHTck]

Literally let's wait and see. This was a 460 patients study so it will be very detailed.