PGE2 Fast Tracks Tissue Regeneration

[hellouser]

Portion of article:

In news that sounds like it’s come straight out of science fiction, researchers in the US have discovered a drug that rapidly repairs damage to the colon, liver and bone marrow in mice, without any adverse side effects. It even saved the lives of mice that would have otherwise died as a result of a bone transplant.The drug hasn’t been tested on people just yet, but the team are now working on developing it for human use within the next three years, with the hope that it could drastically reduce recovery times and improve survival outcomes after surgery and injury.

"We are very excited," lead researcher Sanford Markowitz, an oncologist from Case Western Reserve University in the US, said in a press release. "We have developed a drug that acts like a vitamin for tissue stem cells, stimulating their ability to repair tissues more quickly."
Based on the initial results in animal models, which have been published in the journal Science, the team will first look at trialling the drugs in patients have ulcerative colitis, or are about to undergo bone marrow transplants or liver surgery – but in the future they hope to see whether it could more broadly speed up the repair of tissues around the body.

"The drug heals damage in multiple tissues, which suggests to us that it may have applications in treating many diseases," said Markowitz.
The drug, which goes by the un-catchy name of ‘SW033291’, works by enabling a natural molecule in the body known as prostaglandin E2, or PGE2. Scientists have long known that PGE2 helps the proliferation of adult stem cells - which play a crucial role in healing by differentiating into new cell types as required within their tissue.

Source:
http://www.sciencealert.com/a-new-drug-has-been-found-that-fast-tracks-tissue-regeneration

 

[Ziggyz123]

Interesting. You're always on top of your game dude. Hopefully this drug can repair damaged follicles and when I say hopefully, I mean please god let this be released ASAP.

Where did you hear about this Hellouser?

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Oh sorry I see the link!

 

[Wolf Pack]

Portion of article:



Source:
http://www.sciencealert.com/a-new-drug-has-been-found-that-fast-tracks-tissue-regeneration

Great. On a side note Minoxidil increases PGE2 and I remember it also promoted good healing of surgical scars in rabbit/mice. They were thinking about trying it in humans for wound healing post surgery. For this I guess Minoxidil may have worked in theory as ensures not too much collagen is laid and increases prostaglandins in the area.

 

[resu]

Great. On a side note Minoxidil increases PGE2 and I remember it also promoted good healing of surgical scars in rabbit/mice. They were thinking about trying it in humans for wound healing post surgery. For this I guess Minoxidil may have worked in theory as ensures not too much collagen is laid and increases prostaglandins in the area.

Minoxidil failed completely flat when it came to blood vessel regeneration, there's a study out there if you want to find it.

 

[Fena2000]

Interesting. You're always on top of your game dude. Hopefully this drug can repair damaged follicles and when I say hopefully, I mean please god let this be released ASAP.

Where did you hear about this Hellouser?

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Oh sorry I see the link!

Would be nice, but something is destroying our follicles. If PGE2 Repaired our follicles, that something (which we dont know yet) will keep destroying it. Not until that can be blocked, PGE2 will be beneficial to repair what is broken. Or am I wrong?

 

[KiNGTyreZe]

Portion of article:



Source:
http://www.sciencealert.com/a-new-drug-has-been-found-that-fast-tracks-tissue-regeneration

Any group buy planned? How can we cook that?

SW033291

 

[frenchy]

Great. On a side note Minoxidil increases PGE2

there are studies that says the opposite if i remember well

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Any group buy planned? How can we cook that?

SW033291

there s a GB for pge2

 

[KiNGTyreZe]

there are studies that says the opposite if i remember well

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there s a GB for pge2

Seti isn't SW033291.
You can find PGE2 also in Aspirin.
I've asked for a GE for SW033291.

 

[frenchy]

You can find PGE2 also in Aspirin.

quick search on google, found aspirin decrease PGE2

 

[drgs_not_hugs]

There are pge2 creams and gels used to induce labor, which may be used as analogues
ex. Cerviprost (dinoprostone), but this is obviously not for retail sale

Some abortion drugs have some effect on pge2

 

[KiNGTyreZe]

quick search on google, found aspirin decrease PGE2

F-ck you got me. Still doesn't answer my question.

 

[frenchy]

there isn't, but since the action of this drug is to upregulate pge2, why not take the available pge2 in GB instead?

 

[KiNGTyreZe]

there isn't, but since the action of this drug is to upregulate pge2, why not take the available pge2 in GB instead?

I heard most things upregulate PGE2. This however may act differently.

 

[alscarmuzza]

I heard most things upregulate PGE2. This however may act differently.

15-hydroxyprostaglandin dehydrogenase (15-PGDH), degrades and reduces the amount of PGE2 in the body. The drug in question (SW033291) inhibits 15-DGDH and allows PGE2 to increase in tissues.

 

[hellouser]

There's a group buy on ******** for PGE2. If anyone is interested, PM me. I'm taking part in it.