Some_Dude said:I've recently switched from Propecia to Proscar in order to cut some costs. I'm noticing that Proscar isn't doing as well a job as Propecia did. Is this common or should I go back on Propecia or just ride it out?
Rage said:People seem to forget, Proscar is taken as 5mg tablets for treatment of prostate enlargement.. from memory, only 1% of them had side-effects associated directly from finasteride.
The difference between increase in finasteride and DHT levels is NOT linear! An increased dosage of 25% finasteride would probably only decreases DHT levels an additional 2% or so. But to my knowledge, the company making propecia/proscar never did publish the data pertaining to the affinity of finasteride to 5ar.
de Gaulle said:Rage said:People seem to forget, Proscar is taken as 5mg tablets for treatment of prostate enlargement.. from memory, only 1% of them had side-effects associated directly from finasteride.
The difference between increase in finasteride and DHT levels is NOT linear! An increased dosage of 25% finasteride would probably only decreases DHT levels an additional 2% or so. But to my knowledge, the company making propecia/proscar never did publish the data pertaining to the affinity of finasteride to 5ar.
Rage,
So you claim that raising the level of finasteride in one's body won't raise the side effects? I have a VERY hard time to believe this.
Then, at which level of finasteride do side effect stop? Maybe Merck should release a "light" version of Propecia with no side effect?
In my opinion, by raising the level of finasteride by 25% in someone's body, we could very much be raising his chance of getting side effects by 25% ... it could very much be a linear relationship in fact! We don't know... it depends on person's specific reaction.
Now, as far as the study that says that only 1% of Proscar users have side effects, again I have some difficulties to accept this as a realistic fact: how come would Propecia's users experience side effects more often than Proscar users (2% vs 1%)?
This just doesn't make any sense, and therefore I still believe that cutting Proscar pills into fourths is a dangerous thing to do.
de Gaulle.
drinkrum said:While comparing Propecia and Proscar, keep in mind the reference groups for each drug. Propecia users tend to be young men (18-41) whereas Proscar users are all old men (55+). Clearly, an older man in his 60's will be less likely to notice sexual side effects than a 20-year old.
drinkrum said:You can read all about the effect of finasteride at different dosages at the following Web sites. A quick synopsis: A 0.20 mg dose is about the same as any dose above it in terms of blocking DHT.
de Gaulle said:drinkrum said:While comparing Propecia and Proscar, keep in mind the reference groups for each drug. Propecia users tend to be young men (18-41) whereas Proscar users are all old men (55+). Clearly, an older man in his 60's will be less likely to notice sexual side effects than a 20-year old.
Thank you for pointing this out: I was also going to mention this fact...
drinkrum said:You can read all about the effect of finasteride at different dosages at the following Web sites. A quick synopsis: A 0.20 mg dose is about the same as any dose above it in terms of blocking DHT.
Therefore increasing the amount of finasteride beyond 0.2mg will ONLY increase the chance for side effects!
Conclusion: Do not split Proscar in fourths to treat your hairloss and try to save money!! You are taking too many risks that you may have to pay for later anyway...
de Gaulle.
Bismarck said:General, Finastride decreases DHT in the blood. A study has shown that 5mg reduces only 0.5% more DHT the 1mg dose. The proscar users of the trial you mentioned had less side effects because they were older and therefore less sensitive to hormonal changes than the propecia trialists.
drinkrum said:Not necessarily. The side effects stem from the decrease in DHT and also probably from the subsequent increase in estrogen. If the amount of DHT being blocked is the same, it doesn't make sense that the side effects should increase, does it?
D.
drinkrum said:Also, remember that people don't have to split the pill into 4ths. They can split it into 5ths or even 8ths. The choice is up to them but still buying Proscar will result in sizable cost savings. For the people that do split it into 4ths, I would recommend that for every 5th day, they take nothing so as to maintain a 1 mg/day effective dosage.
D.
Rage said:de Gaulle,
they have tested finasteride - and found no interaction with anything except with 5ar.
but it is your money, so its definitely up to you.
de Gaulle said:drinkrum said:Not necessarily. The side effects stem from the decrease in DHT and also probably from the subsequent increase in estrogen. If the amount of DHT being blocked is the same, it doesn't make sense that the side effects should increase, does it?
D.
If the side effects are ONLY due to the decrease in DHT level, you are right. If these side effects are caused by the interraction of finasteride on hormones there is still a greater risk for them to occur.
de Gaulle.