Public Enemy #1- Lipopolysaccharides leaking in thru our guts.

[OtyMac]

How to reduce systemic LPS damage? Many ways:

1) Nutrafol select probiotic strains. This is NOT the herb based Nutrafol people have used in the past.

Exploring the Connection Between Gut Health and Hair

Sponsored by Nutrafol®

practicaldermatology.com

2 vitamin d3-

Vitamin D3 affects the gut microbiota in an LPS-stimulated systemic inflammation mouse model​

https://www.sciencedirect.com/science/article/pii/S1286457923000837

3) a good link from selfhacked for other things:

14 Factors that May Reduce Lipopolysaccharides (LPS) - SelfHacked

Lipopolysaccharides can cause health problems when they enter the blood. Find out about their health risks & factors that may reduce them here.

selfhacked.com

Remember we have perifollicular inflammation and LIPO-polysaccharides WILL end up in sebum:

Skin Immunity and LPS / What's LPS / Macrophi Inc. | LPS material | innate immunity | R&D

 

[OtyMac]

IL-17A is implicated in lipopolysaccharide-induced neuroinflammation and cognitive impairment in aged rats via microglial activation​

Anti-IL-17A may represent a new therapeutic strategy for the treatment of endotoxemia-induced neuroinflammation and cognitive dysfunction.

Repigmentation And New Growth Of Hairs After Anti–interleukin-17 Therapy With Secukinumab​

https://www.hairlosstalk.com/interact/threads/repigmentation-and-new-growth-of-hairs-after-anti-interleukin-17-therapy-with-secukinumab.114788/

 

[OtyMac]

Here the gut microbiome is also implicated in another androgen driven disorder.

The role of gut microbiota in prostate inflammation and benign prostatic hyperplasia and its therapeutic implications​

https://www.cell.com/heliyon/fulltext/S2405-8440(24)14333-2

Conclusion​

Short-chain fatty acids (SCFAs), which are metabolites of the intestinal microbiota, protect the integrity of the intestinal barrier, regulate immunity, and inhibit inflammation. However, dysregulation of the gut microbiota significantly reduces the SCFA content in feces and impairs the integrity of the gut barrier, leading to the translocation of bacteria and bacterial components such as lipopolysaccharide, mediating the development of prostate inflammation through microbe-associated molecular patterns (MAMPs).

 

[bags]

I hate to be the bearer of bad news but everything you’re posting here has been beaten to death.

The answer to everything your positing is: Tacrolimus.

And yes, go outside and get some sun along with cleaning up your entire lifestyle.

 

[OtyMac]

Each molecule that has been shown to grow hair(not talking about some topical that grows in reality a few sprigs of hair) either stops LPS from entering the bloodstream or counters the rise in IL-17 from failing to do that.

The key is to use many different substances that fly under the radar of side effects.




Tacrolimus is no different

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Tacrolimus can reduce the production of IL-17 and the expression of Th17 cells, which mainly produce IL-17. Tacrolimus can also inhibit the pro-inflammatory effects of IL-17 and TNF-α on human keratinocytes.

 

[OtyMac]

Each molecule that has been shown to grow hair(not talking about some topical that grows in reality a few sprigs of hair) either stops LPS from entering the bloodstream or counters the rise in IL-17 from failing to do that.

The key is to use many different substances that fly under the radar of side effects.




Tacrolimus is no different

AI Overview
Learn more

View attachment 189244
Tacrolimus can reduce the production of IL-17 and the expression of Th17 cells, which mainly produce IL-17. Tacrolimus can also inhibit the pro-inflammatory effects of IL-17 and TNF-α on human keratinocytes.

Also, while sunlight is great for vitamin d production not everybody can convert it either. Somebody posted that study in hairlosstalk. Some have had great results with vitamin d so I wouldn't just broadly dismiss it as casually as you do.

There are other factors of vitamin d status also to consider:

Sunlight exposure is just one of the factors which influence vitamin D status - PubMed

Studies on the determinants of vitamin D status have tended to concentrate on input - exposure to ultraviolet B radiation and the limited sources in food. Yet, vitamin D status, determined by circulating concentrations of 25-hydroxyvitamin D (25(OH)D), can vary quite markedly in groups of people...

pubmed.ncbi.nlm.nih.gov

Studies on the determinants of vitamin D status have tended to concentrate on input - exposure to ultraviolet B radiation and the limited sources in food.

{Yet, vitamin D status, determined by circulating concentrations of 25-hydroxyvitamin D (25(OH)D), can vary quite markedly in groups of people with apparently similar inputs of vitamin D. }

There are small effects of polymorphisms in the genes for key proteins involved in vitamin D production and metabolism, including 7-dehydrocholesterol reductase, which converts 7-dehydrocholesterol, the precursor of vitamin D, to cholesterol, CYP2R1, the main 25-hydroxylase of vitamin D, GC, coding for the vitamin D binding protein which transports 25(OH)D and other metabolites in blood and CYP24A1, which 24-hydroxylates both 25(OH)D and the hormone, 1,25-dihydroxyvitamin D. 25(OH)D has a highly variable half-life in blood.

{There is evidence that the half-life of 25(OH)D is affected by calcium intake and some therapeutic agents.}

Fat tissue seems to serve as a sink for the parent vitamin D, which is released mainly when there are reductions in adiposity. Some evidence is presented to support the proposal that skeletal muscle provides a substantial site of sequestration of 25(OH)D, protecting this metabolite from degradation by the liver, which may help to explain why exercise, not just outdoors, is usually associated with better vitamin D status.

 

[OtyMac]

This is interesting in that nitric oxide donors(low dose oral Loniten) have a skewed killing ability towards gram negative bacteria in our guts.
Remember the LPS fragment which causes all the subsequent systemic damage comes from gram negative bacteria.



AI Overview

https://support.google.com/websearch?p=ai_overviews&hair loss=en
Nitric oxide (NO) donors are compounds that release nitric oxide, and they can be highly effective against Gram-negative bacteria due to NO's ability to disrupt their outer membrane, causing cell damage and death; this is because Gram-negative bacteria lack a thick peptidoglycan layer which makes them more susceptible to NO penetration compared to Gram-positive bacteria.

 

[OtyMac]

AI Overview


5-alpha reductase and IL-17 are both linked to prostate health, with 5-alpha reductase being an enzyme that converts testosterone into dihydrotestosterone (DHT), a key hormone involved in prostate growth, while IL-17 is a pro-inflammatory cytokine that has been implicated in the development of benign prostatic hyperplasia (BPH) by promoting inflammation within the prostate tissue, potentially contributing to its enlargement; essentially, high levels of IL-17 can exacerbate the effects of DHT on the prostate.


Key points about the connection between 5-alpha reductase and IL-17:

• Role in BPH:
  Research suggests that increased IL-17 levels are associated with BPH, and its presence in prostate tissue can contribute to inflammation and tissue remodeling, which can lead to prostate enlargement.
• 
  
• Mechanism of action:
  While 5-alpha reductase directly impacts the production of DHT, IL-17 indirectly influences prostate health by triggering inflammatory pathways that can enhance the effects of DHT on prostate cells. (ME: well idn't that just speshul..said in a Dana Carvey church-lady voice)
  
  
• 
  
• Clinical implications:
  This connection is important because it highlights the potential role of anti-inflammatory therapies alongside 5-alpha reductase inhibitors (like finasteride) in managing BPH symptoms.
  

 

[OtyMac]

Glutamine supplementation is a verrrry interesting lil compound in repairing gut health. And lets say one would hypothetically do that(wink) then probably take it on an empty stomach avoiding a competition for receptor space by other junk(molecules we are not interested in) in the way.

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Glutamine plays a protective role in gut health by mitigating the negative effects of lipopolysaccharide (LPS), a bacterial toxin that can trigger inflammation when the gut barrier is compromised; studies show that glutamine supplementation can help maintain intestinal integrity, reduce inflammation caused by LPS, and support the function of tight junctions in the gut lining, essentially acting as a barrier against harmful substances like LPS.


Key points about glutamine and LPS in gut health:

• Reduces inflammation:
  When exposed to LPS, glutamine can suppress the production of inflammatory cytokines like TNF-alpha and IL-6, helping to alleviate inflammation in the gut lining.
  

• Maintains tight junctions:
  Glutamine supports the expression of tight junction proteins, which are crucial for maintaining the integrity of the intestinal barrier and preventing the leakage of LPS into the bloodstream.
  
  
• Enterocyte function:
  Glutamine serves as a primary energy source for enterocytes (intestinal cells), promoting their health and function, which is vital for a healthy gut barrier.
  
  
• Immune system support:
  By mitigating inflammation, glutamine can also positively impact the immune response within the gut, helping to regulate immune cell activity.
  

Important considerations:

• Dosage matters:
  The optimal dosage of glutamine for gut health needs to be determined based on individual needs and should be discussed with a healthcare professional.
  

• Underlying conditions:
  Individuals with specific medical conditions, like kidney disease, should consult their doctor before supplementing with glutamine.
  
  

Not surprisingly, we find that inflammation appears at least in this study thru LPS to cause obesity.

Oral Glutamine Supplementation Reduces Obesity, Pro-Inflammatory Markers, and Improves Insulin Sensitivity in DIO Wistar Rats and Reduces Waist Circumference in Overweight and Obese Humans - PMC

In the present study, we aimed to investigate whether chronic oral glutamine (Gln) supplementation may alter metabolic parameters and the inflammatory profile in overweight and obese humans as well as whether Gln may modulate molecular pathways in ...

pmc.ncbi.nlm.nih.gov

The volunteers received a kit containing small packs with 15 g of amino acid (Gln or Ala) each. They were instructed to take two packs per day, taking a total of 30 g of amino acids per day. The supplementation lasted for 14 days. The volunteers were instructed to mix the pack content in a cup of water (200 mL) before drinking and maintain the same levels of physical activity and the same diet during the 14 days of supplementation.

There was a clear positive correlation between reductions in LPS circulating levels and reductions in waist circumference after glutamine supplementation in overweight and obese subjects (r = 0.629), as shown in Figure 1.

 

[Analogies]

As someone who has been trying to fix my gut and I’ve had BPH in the past, anytime I took L-glutamine I experienced sharp prostate pain.

 

[Armando Jose]

IMHO, If Gut microbiota affects to hair , the effect would be in all scalp hairs, not only in pattern hair loss

 

[OtyMac]

Many skin diseases have patterns and it is baffling to researchers but they are attempting to explain some of it in the below paper. IMO, leakage of LPS because of a damaged gut lining probably effects all organs but is most noticeable in the scalp first.

https://karger.com/imi/article/4/1-2/1/176285/The-Puzzle-of-the-Skin-Patterns

Most skin diseases show a predilection for certain body areas and are located in characteristic patterns. Many dermatoses exhibit lesions in a segmental fashion concomitantly with disseminated patterns. Sometimes the sites of predilection are inexplicable.

 

[Armando Jose]

Thanks OtyMac for the paper, it is interesting due skin are very linked to nervous system, but oddly no any reference at patterned hair loss.

 

[OtyMac]

I notice hair loss patterns in animals too in the same areas every time it is not pattern or location driven in humans or animals IMHO. Even certain birds are said to have male pattern baldness.

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Many animals experience hair loss for a variety of reasons, including:

• Pattern baldness
  A genetic disorder that causes symmetrical hair loss in some dog breeds, including dachshunds, greyhounds, and chihuahuas. It's primarily cosmetic and doesn't cause pain, itching, or swelling.
  
  
• Alopecia
  A condition that causes hair loss in areas of the body that are normally covered in hair. It can be caused by a number of factors, including genetics, hypersensitivity, or nutritional issues.
  
  
• Andean bear alopecia
  An itchy baldness caused by an immune-mediated process similar to eczema in humans.
  
  
• Color dilution alopecia
  An inherited disease in dogs that can be managed with shampoos, rinses, ointments, antibiotics, and nutritional recommendations.
  
  
• Alopecia X
  A condition in dogs that can be treated with melatonin, which may cause partial to complete hair regrowth.

The human Androgenetic Alopecia follicle is capable of regrowing when transplanted onto SCID mice so the follicle is functional.

 

[Armando Jose]

Human common hair loss is unique. Human hair is the only one that have asynchronicity cycles, primates, and less in pigs, is the genus more evoluted in hair.

 

[OtyMac]

Armando, tell me what's on your mind.

I've realized the contributions of others all add up to a cumulative intelligence effect. Only one person will get a certain percentage correct. As they say, you don't know what you don't know...

Wisdom of The Crowds is an interesting concept:

The Wisdom of Crowds - Wikipedia

en.wikipedia.org

The opening anecdote relates Francis Galton's surprise that the crowd at a county fair accurately guessed the weight of an ox when their individual guesses were averaged (the average was closer to the ox's true butchered weight than the estimates of most crowd members).[1][2]

 

[Armando Jose]

Interesting
"“the decisions of very large groups may be highly accurate when the information used is independently sampled, but they are particularly susceptible to the negative effects of correlated information, even when only a minority of the group uses such information.”

 

[Armando Jose]

Armando, tell me what's on your mind

common hair loss is derived by cultural practice. women&men scalp hair is the same with a accurate 99,5%,..., then, why incidence is so different?

 

[OtyMac]

I think epigenetics as that was demonstrated in the identical twin studies.

The contribution of endogenous and exogenous factors to male alopecia: a study of identical twins​

The Contribution of Endogenous and Exogenous Factors to Male Alopecia | 10.1097/prs.0b013e3182865ca9_Science Hub

www.tesble.com

The contribution of endogenous and exogenous factors to female alopecia: a study of identical twins​

https://www.tesble.com/10.1097/prs.0b013e31826d104f

 

[Armando Jose]

A picture is worth 1000 words. Newborn twin boys with different hair types. Without influence from the outside, same diet and same external factors.