Question About Tsuji's Method Again

[NeverBaldEver]

People may ask me to dig in some the old threads, which is less direct. And maybe my questions could include new ones.

1) Quality of the regenerated follicles: How does he know the regenerated follicles are resistant to DHT?
I don't think the stem cells in the donor area could generate follicles resistant to DHT for sure, but maybe I am wrong.
If not, the procedure could have certain efficacy in the first few months/years, but the effect could fade overtime. Or the procedure needs to be repeated (but the effect is great if it is done in repeatedly), it will become another RCH-01 and doesn't worth the high cost reported today.

2) There are multiple mechanisms about follicle miniaturization. Follicles are attacked by DHT, but once it starts miniaturizing, it is hard to stop or reverse even when DHT is cut off, since certain type of muscle (I forgot its name, sorry) is detached from the follicle. How could the regenerated follicles overcome this difficulty and get attached to the muscles? Or is it true that a "complete" follicle also includes the muscle and the regeneration will recover that?

So much for now, maybe more in the future.

Thanks.

(No body knows could also be a legitimate answer if no official/academic information about them is available)

 

[BalderBaldyBald]

People may ask me to dig in some the old threads, which is less direct. And maybe my questions could include new ones.

1) Quality of the regenerated follicles: How does he know the regenerated follicles are resistant to DHT?
I don't think the stem cells in the donor area could generate follicles resistant to DHT for sure, but maybe I am wrong.
If not, the procedure could have certain efficacy in the first few months/years, but the effect could fade overtime. Or the procedure needs to be repeated (but the effect is great if it is done in repeatedly), it will become another RCH-01 and doesn't worth the high cost reported today.

2) There are multiple mechanisms about follicle miniaturization. Follicles are attacked by DHT, but once it starts miniaturizing, it is hard to stop or reverse even when DHT is cut off, since certain type of muscle (I forgot its name, sorry) is detached from the follicle. How could the regenerated follicles overcome this difficulty and get attached to the muscles? Or is it true that a "complete" follicle also includes the muscle and the regeneration will recover that?

So much for now, maybe more in the future.

Thanks.

(No body knows could also be a legitimate answer if no official/academic information about them are available)

1) They know primordiums are resistant to DHT because they've tested it in-vitro/ex-vivo, simply by exposing them to DHT.

2) Tsuji/Kyocera/Riken already stated that hair follicle primordiums will connect to existing tissues, nerves and to the arrector pili muscle, POC was done on mice, still waiting for human trials results

Source : https://global.kyocera.com/news-archive/2016/0702_nfid.html

 

[Subigang]

If you guys don’t mind, one more question: what kind of density are you guys thinking Tsuji will achieve?

Are we talking hair transplant (pretty artificial looking) levels of density or more natural looking levels of density?

I know nobody really knows, but theoretically?

 

[MeDK]

Dense as a beaver.

You are asking about something that haven't even released anything about human trails.

No one knows anything about this treatment. Its all based on something that happens years ago and nothing new have really happened since then.

We all know that mouse models and other animals models, doesn't translate into humans, far from it.

 

[PlsTsuji]

Do they transplant the new hair like the usually would in a hair transplant or with an injection?

 

[GrowPro]

Not to sound too pessimistic but even if this treatment is successfully able to clone/multiply a persons DHT resistant donor cells tens of thousands of times that does not necessarily mean once injected back into a persons scalp that their body will be able to create blood vessels and a strong blood supply to each new dermal papilla, so it can be dependant on the persons healing ability and how deep into the scalp they inject the cloned cells and will there be enough “strength” in the cells while in the scalp to gain a blood supply to latch onto and is there a possibility that even the slightest bit of scar tissue development from the injection kills off the cloned cells. In Hair transplants the doctor has to create an incision deep enough for there to be enough wounded action that once a graft is placed it will compel the body to create new blood vessels to connect to the graft hence the growth in 3-4 months time, will Dr Tsuji’s method successful take to a humans scalp is a big hurdle and that why I believe he hasn’t released any trial photos, but I do hope he figures it out.

 

[BalderBaldyBald]

We all know that mouse models and other animals models, doesn't translate into humans, far from it.

For drugs i agree, even if they use mouse models because they're very similar to us, it does not always translate into humans.

But here, we're talking about surgeries, a whole other matter
You can survive as a human with a grafted pig liver...and it'll be fully functional...for some days

 

[Bboy321]

can Tsuji’s method resolve gray hair problem btw ?
If you can replace all of your gray hair with the cloned follicles that would be amazing !

 

[Ollie]

Not to sound too pessimistic but even if this treatment is successfully able to clone/multiply a persons DHT resistant donor cells tens of thousands of times that does not necessarily mean once injected back into a persons scalp that their body will be able to create blood vessels and a strong blood supply to each new dermal papilla, so it can be dependant on the persons healing ability and how deep into the scalp they inject the cloned cells and will there be enough “strength” in the cells while in the scalp to gain a blood supply to latch onto and is there a possibility that even the slightest bit of scar tissue development from the injection kills off the cloned cells. In Hair transplants the doctor has to create an incision deep enough for there to be enough wounded action that once a graft is placed it will compel the body to create new blood vessels to connect to the graft hence the growth in 3-4 months time, will Dr Tsuji’s method successful take to a humans scalp is a big hurdle and that why I believe he hasn’t released any trial photos, but I do hope he figures it out.

I mean we're talking about a man who may well be one of the brightest guys in that particular field on the planet - i'm sure they've thought through all the trivial details.

 

[GrowPro]

I mean we're talking about a man who may well be one of the brightest guys in that particular field on the planet - i'm sure they've thought through all the trivial details.

I hope so, I would love it for them to have figured it all out from safety to growth to mass production to lower the cost rapidly enough for the average person to be able to afford it.

 

[Subigang]

Prayin for density yo