RepliCel's Partner, Shiseido, Opens Cell Processing and Expansion Facility in Japan.

[JZA70]

RepliCel Life Sciences Inc. a clinical stage regenerative medicine company focused on the development of autologous cell therapies, is pleased to announce that its RCH-01 licensing partner, Shiseido, celebrated the opening of its new cell-processing facility at the Kobe Biomedical Innovation Cluster (KBIC) located on Port Island, Japan on May 18, 2014. Dignitaries, physicians, partner companies, and government representatives were in attendance at this important event. Shiseido's state-of-the-art facility will focus on the continued research and development, and the commercialization of RepliCel's RCH-01 hair regeneration technology.

http://www.marketwatch.com/story/re...1-a-treatment-for-pattern-baldness-2014-05-20

 

[RK85]

RepliCel Life Sciences (TSX.V:RP)(OTCMKTS:REPCF), as its name implies, is in the biotechnology space of cell repair, replacement and regeneration. With applications as diverse as treatment for chronic tendon injuries to baldness, the company has the exclusive rights to market its products in Japan, China and South Korea. The concept of the technology is that Replicel uses cells isolated from a patient’s own healthy hair follicles to address specific cellular deficits.

The company is in the process of raising a targeted $7.5 million in a brokered private placement offering a share for $0.75 with a two year warrant at $1.00. The company reported a loss of $28,572 on revenue of $4.1 million, compared with a loss of $3.4 million on zero revenue in 2012. That is certainly movement in the right direction, and it will be sales of products in Asia that will drive the bus forward in 2014. An audio interview with CEO David Hall will be broadcast on Midas Letter’s iTunes CEO Podcast Channel next week.

http://www.midasletter.com/2014/04/canadas-killer-technology-stocks/

 

[Python]

Replicel is not worth the time

 

[JZA70]

Replicel is not worth the time

If you say so.. :jackit:

 

[benjt]

I still think that RepliCel will be the first ones to make the race. A couple of indicators:

• their method is based on solid science which has been confirmed in previously published papers, most notable the role of DP cup cells
• their major cooperation partner for Phase IIb trials is the Charite Berlin, Europe's most research-intensive and renowned university hospital - which is, as far as I know, where the Berlin-based researchers grew those artificial hairs on chips who were also at the hair congress
• one of the world's biggest cosmetics companies was willing to provide millions of dollars in funding and to agree on a pay-per-milestone contract, i.e. they are certain that RepliCels method works. This is, by the way, where Dr. Cotsarelis' Follica failed: To convince one or multiple important investors that their method is, in its current state, marketable and profitable.

I guess the last point is the most important one: An external, revenue-oriented entity has evaluated the efficacy of RepliCel's approach and considers it to be working, marketable, and profitable. They believe that people are willing to pay a sh*tload of money to get RepliCel's treatment, thus making me quite optimistic that it indeed works.

 

[hellouser]

I still think that RepliCel will be the first ones to make the race. A couple of indicators:

• their method is based on solid science which has been confirmed in previously published papers, most notable the role of DP cup cells
• their major cooperation partner for Phase IIb trials is the Charite Berlin, Europe's most research-intensive and renowned university hospital - which is, as far as I know, where the Berlin-based researchers grew those artificial hairs on chips who were also at the hair congress
• one of the world's biggest cosmetics companies was willing to provide millions of dollars in funding and to agree on a pay-per-milestone contract, i.e. they are certain that RepliCels method works. This is, by the way, where Dr. Cotsarelis' Follica failed: To convince one or multiple important investors that their method is, in its current state, marketable and profitable.

I guess the last point is the most important one: An external, revenue-oriented entity has evaluated the efficacy of RepliCel's approach and considers it to be working, marketable, and profitable. They believe that people are willing to pay a sh*tload of money to get RepliCel's treatment, thus making me quite optimistic that it indeed works.

Don't be TOO sure. To play devil's advocate, Aderans also purchased Bosley for many milions of dollars. When this broke news many people thought that their clinics would be used as a location to deliver the treatment. This of course never happened, Aderans got their funding pulled and the whole project was scrapped after finishing Phase II trials.

 

[curiouscat]

Hi Benjt. I know this is in the wrong forum; however, I would LOVE your insight. I am a 26 year old female & my sister gave me some minoxidil for my eyebrows.

I used it twice on May 17th & my eyes have dark, sorta puffy circles.

Did you ever recover from this & how can I speed up the process?

I am so depressed. Please help.

 

[Python]

Hi Benjt. I know this is in the wrong forum; however, I would LOVE your insight. I am a 26 year old female & my sister gave me some minoxidil for my eyebrows.

I used it twice on May 17th & my eyes have dark, sorta puffy circles.

Did you ever recover from this & how can I speed up the process?

I am so depressed. Please help.

Hey, cat, I have seen this issue arise before with minoxidil and well I would say it is not good. It can be permanent and I hate to say that to you but that I what I have seen on other forums. I would like maybe advice you use cucumbers an see if that helps. For eyebrows and eyelashes we now have latisse which is very effective for those areas.

 

[IDW2BB]

Very interesting interview with David Hall:


http://www.replicel.com/replicel-tr...ar-deficits-an-interview-with-ceo-david-hall/

 

[benjt]

Hi Benjt. I know this is in the wrong forum; however, I would LOVE your insight. I am a 26 year old female & my sister gave me some minoxidil for my eyebrows.

That was insanely stupid. Minoxidil started off as a vasodilator and treatment for blood pressure. I assume that the package insert in the US also states that drugs are only to be applied as specified, i.e. on your scalp.

I used it twice on May 17th & my eyes have dark, sorta puffy circles.

As you used it only twice there is nothing to worry about. The darkness comes from vasodilation and will disappear in most cases within two or three weeks max. As you used it only twice and only on one day, it will probably disappear quicker - give it a week. The puffiness comes from water retention which is, by the way, also listed as a side effect in the package insert. Drink lots of green or black tea as they are diuretics.

Did you ever recover from this & how can I speed up the process?

I recovered from most of my side effects; however, as I used minoxidil for almost 12 months in a row at that time, it took me much longer to recover. To speed up the recovery from the dark color around your eyes, do lots of sports. Even if you don't do sports, it will vanish in 3 weeks max, but in your case likely quicker as you used minoxidil only twice. As stated above, to get rid off the puffiness, drink good amounts of green and/or black tea (e.g., three to five pots a day). It will vanish within a week.

I am so depressed. Please help.

Use drugs only as specified.


@IDW2BB: Good find once again.

 

[benjt]

Don't be TOO sure. To play devil's advocate, Aderans also purchased Bosley for many milions of dollars. When this broke news many people thought that their clinics would be used as a location to deliver the treatment. This of course never happened, Aderans got their funding pulled and the whole project was scrapped after finishing Phase II trials.

In my line of work (applied research), there is a huge difference between acquiring a whole company or providing funding to it. Generally, funding another company means in most cases that the capital supplier is much more confident in the whole thing working than if he bought the company. Buying a company is only done under two circumstances: 1) it fits the portfolio or allows market entrance while providing absolute certainity of revenue that exceeds the company's price even in the short term, 2) eliminate competition. 2) happens much more frequently than 1) in my line of work.

I cant say if that was definitely what happened with Aderans, but externally funding (instead of acquiring) RepliCel, especially with such sums (and with an exclusive market license) makes me much more comfortable than RepliCel being bought, for the aforementioned reasons, as can be seen with the Aderans example.

 

[2young2retire]

it seems legit shisheido is listed officialy in the kobe bussiness expansion sheet.
as biomedical bussiness regerenative supprt.
what could make us now more optimistic is pictures inside the cell factory and hair scientists working 24/7

http://www.kobe-lsc.jp/wp-content/themes/kbic/pdf/listing_companies_e.pdf

- - - Updated - - -

shisheido worker.

http://mms.businesswire.com/media/20140421005994/en/412100/5/SPEC%E5%86%85%E3%81%A7%E3%81%AE%E7%B4%B0%E8%83%9E%E5%9F%B9%E9%A4%8A.jpg

 

[I.D WALKER]

Thanx ID for the interesting read. Mr. Hall's answers certainly propagate a continuum of discourse on the endless scientific possibilities of the technological delivery devices and so forth. The good news is that hope is not always a four letter word. Just a little word of caution about Regemmed Cell Therapy Group( the guys providing the refined infomercial) They are a multi-million dollar profit , marketing consultant firm. Their client base is mainly comprised of giant corporations and/or highly skilled and functioning money generators, generally found in the realm of medicine At face value there may be nothing wrong that. On the other hand, absolute objectivity dictates that we must look at the mutual conflict of interest that flows between their relationships and we do this by using simple business logic. Cell Therapy Group strength partly lies in it's excellent ability to provide it's up and coming clients with very astute and polished marketing support at times brimming with clever sensationalism. When it comes to their own as well as their special clients' huge market and profit potential two question of ethics begs should be justly asked of them. To what extent will Cell Therapy Group go to Propecia up these capable and respected companies and to what degree does their commitment and dedication to their clients' consummate satisfaction compromise scientific integrity? Thanx for sharing.

Very interesting interview with David Hall:


http://www.replicel.com/replicel-tr...ar-deficits-an-interview-with-ceo-david-hall/

 

[curiouscat]

Thank you. Yeah my older sister gave me some and I trusted her but now I am suffering!

She said it worked for her with no problem. I will try cucumbers.

- - - Updated - - -

Benjt, ugh! My sister told me she used it & gave me some in a bottle. I was gullible and trusted. Never again!

Thank you for the advice. I am fair skinned and these "eye rings" make me look like a druggy or tired.

Did you get dark eye rings and puffiness, as well?

So, just sweat it all out?

Thank you for helping.

 

[I.D WALKER]

If it's perspiration you are aspiring for then it won't hurt to down those cucs regularly with a double dose of serrano peppers. That will put a fire under your umbrella if nothing else does. nfire::sun:

 

[JZA70]

Benjt, ugh! My sister told me she used it & gave me some in a bottle. I was gullible and trusted. Never again!

Thank you for the advice. I am fair skinned and these "eye rings" make me look like a druggy or tired.

Did you get dark eye rings and puffiness, as well?

So, just sweat it all out?

Thank you for helping.

This site has a PM feature..

 

[benjt]

@curiouscat: As pointed out, such matters can be discussed via PM. I sent you one for your remaining questions.

Back to topic: It's great that they actually erect a facility just for that, just proving they are confident in the whole thing actually working. Problem is that this likely still doesn't change anything about RepliCel's time schedule, i.e. availability in Asia in mid 2019. And as we all know, time schedules are frequently deviated from.

 

[hellouser]

Found a little bit of insight on Replicel's method:

Mesenchymal stem cells (MSCs) isolated from the lower pole of the hair follicle.



Isolation & Growth ConditionsThe MSC-containing dermal sheath cup (DSC) of the hair follicle, is isolated by micro-dissection and propagated in AmnioMax C100 basal medium supplemented with AmnioMax C100. The DSCs are cultivated in 24-well culture flasks under sterile conditions in a 37° C, 5% CO[SUB]2 [/SUB]incubator for a few days, to obtain a near-confluent culture. Cells are then detached with trypsin-EDTA (trypsination is terminated by addition of Amniomax medium) and transferred to 25 ml culture flasks in 5 ml Amniomax medium. The medium is exchanged every 3 days.


Source:
http://discovery.lifemapsc.com/stem...s-replicel-hair-01-replicel-life-sciences-inc

*Note: There's a link in that page that states 'Phase 2'. Not sure if this means they've already started Phase 2, but they will be soon. I'd love to just do the procedure myself if we had all the info on the method

 

[hellouser]

AWESOME NEWS GUYS! And possibly the BEST we've had all year:

This was posted on RepliCel's Twitter page:

“RepliCel/Shiseido is well positioned to take advantage of early conditional approvals in Japan," @CellTherapyBlog

Here's an interesting article about the whole process:
http://www.celltherapyblog.com/

So, looks like I was right on the money when I mentioned the fast tracked approval of stem cell therapy in Japan with the new regulations. This does line up nicely with David Hall's recent comment in an interview that they'll have data in 2016, despite the fact that their official Phase II trial is supposed to last 39 months (which would go all the way until 2017).

 

[I.D WALKER]

Data from 2 (Replicel and Shiseido) concurrent trials is ideally what is needed to incentivate more serious competition. For this means that once safety and early evidence of efficacy is shown the Great Race is finally on. And maybe in a nutshell we can finally believe once a company is approved they are locked into Japan's " regulatory system " and therefore must produce or progress to the next and eventual phase of development(commercialization) mostly due in part to the fact that they are publicly before the firing squad of some big wheel players and international investors and no longer have the luxury to back pedal, stall, or continually paralyze us with more of the same suspenseful, silent treatment. As you can read for yourself Replicel already was awarded (so to speak) several million out of the deal. So from just a business perspective this alone is all wonderfully encouraging. My favorite excerpt from Cell Therapy blog with a minor editorial adjustment discusses the rippling ramifications and investor(global)potential of Japan's new regulatory program. " Naturally companies in the regenerative medicine and cell therapy space OUTSIDEJapan are tripping over themselves to prioritize Japan as part of their corporate planning..,". At last it seems we will soon be reading the Great writing on the Wall(Street) which might be good for those of us worked over on Mane street. Good stuff Poster.