Research focused on stem cells in the hair follicle.

[JZA70]

Stem cells switch off and on, sometimes dividing to produce progeny cells and sometimes resting. But scientists don’t fully understand what causes the cells to toggle between active and quiet states. The researchers found cells produced by the stem cells, progeny known at Transit-Amplifying Cells or TACs, emit a signal that tells quiet hair follicle stem cells to become active.

Surprisingly, when Hsu blocked the ability of the quiescent stem cells to respond to Sonic Hedgehog, hair growth proceeded, but follicles were shorter, and with each round of hair cycling, the quiescent and primed stem cell populations were diminished, until hair regeneration failed altogether. These features are remarkably similar to what happens in male pattern baldness, according to the researchers. Although the root of this disorder may be further upstream than Sonic Hedgehog, this study provides new insights into the manifestations of hair loss, which in the long run will be necessary to develop new therapeutics, they say.

http://newswire.rockefeller.edu/2014/05/08/stem-cell-progeny-tell-their-parents-when-to-turn-on/

 

[hellouser]

So... 10 years? 2-5 years? Or never?

 

[resu]

Stem cells to respond to Sonic Hedgehog?

 

[JZA70]

Stem cells to respond to Sonic Hedgehog?

http://www.dailymail.co.uk/health/article-4083/Hedgehog-cure-baldness.html

The article looks like a load of sh1t but it has the info you're wondering about.

 

[2bald2young]

Stem cells switch off and on, sometimes dividing to produce progeny cells and sometimes resting. But scientists don’t fully understand what causes the cells to toggle between active and quiet states. The researchers found cells produced by the stem cells, progeny known at Transit-Amplifying Cells or TACs, emit a signal that tells quiet hair follicle stem cells to become active.

Surprisingly, when Hsu blocked the ability of the quiescent stem cells to respond to Sonic Hedgehog, hair growth proceeded, but follicles were shorter, and with each round of hair cycling, the quiescent and primed stem cell populations were diminished, until hair regeneration failed altogether. These features are remarkably similar to what happens in male pattern baldness, according to the researchers. Although the root of this disorder may be further upstream than Sonic Hedgehog, this study provides new insights into the manifestations of hair loss, which in the long run will be necessary to develop new therapeutics, they say.

http://newswire.rockefeller.edu/2014/05/08/stem-cell-progeny-tell-their-parents-when-to-turn-on/

Wow this is really a great discovery, we can now make men go bald manually! And now the regrowth part please...

But on a more serious note if they make a product like this that can block the ability of the quiescent stem cells to respond to Sonic Hedgehog, we have the ability to get rid of unwanted bodyhair.

 

[resu]

http://www.dailymail.co.uk/health/article-4083/Hedgehog-cure-baldness.html

The article looks like a load of sh1t but it has the info you're wondering about.

Thanks, quite curious name.

 

[I.D WALKER]

Man some heavy dossier that eager erinaceid holds. This small yet mighty ( linked to heart, lung, skin and even hair) hedgehog gene has also been found to be directly linked to basal cell carcinoma. More succinctly it is thought that when this gene is overexpressed that it does it's best work at conjuring another unpleasant form of skin cancer. On the other hand in the article, it may have been Doctor Crystal himself that stated that in a few years we could have treatment available. Who knows how to gauge this one for the moment, still it's rather fascinating nonetheless.

Thanks, quite curious name.

 

[moskva]

yeah i kinda remember some old news back in 2007, there once was a company who got some similar findings on "hedgehog" pathway, and they managed to do the trial on hair with P&G and others. sadly the results showed a not very good safety profile. that's not a huge surprise cuz in fact the company's major pipeline products are down-regulators of hedgehog, for preventing cancer. If this sonic stuff is the same or similar to the "hedgehog" thing back then, I don't think they'll get much from it. maybe this time they figure out a way to up-regulate it safely, but just hopefully.

 

[Python]

Wow this is really a great discovery, we can now make men go bald manually! And now the regrowth part please...

But on a more serious note if they make a product like this that can block the ability of the quiescent stem cells to respond to Sonic Hedgehog, we have the ability to get rid of unwanted bodyhair.

Imagine if we have a topical to induce baldness, so many possibilities. All those we hate, we can find their gell and mix the topical and see their hair fall out . Muhahahaha, payback b****s

 

[Armando Jose]

Imagine if we have a topical to induce baldness, so many possibilities. All those we hate, we can find their gell and mix the topical and see their hair fall out . Muhahahaha, payback b****s

Yes. You are right,..., is difficult cure common baldness and induce it. Anyone knows some method?