Researchers Find Aging Stem Cells Have A Key Role In Hair Loss

[Joxy]

Why exactly do people go bald or see their hair thinning out as they get older? For decades, researchers studying aging and hair loss have focused on keratinocytes, the cells that make up the bulk of the hair follicle and eventually give rise to the hair fibre. But a study from the University of Calgary Faculty of Veterinary Medicine (UCVM) has found that it’s actually a small population of specialized cells within the hair follicle called fibroblasts, and the dermal stem cells that maintain them, that may cause hair loss.

In a paper published in Developmental Cell, Dr. Jeff Biernaskie, PhD, and his team, led by graduate student Wisoo Shin (pictured above), demonstrate that with increasing age, these dermal stem cells become dysfunctional and lose their ability to self-renew.

“If we ever want to prevent hair loss from happening or resurrect hair growth once you start to lose your hair, we need to focus on maintaining the function of these hair follicle dermal stem cells,” says Biernaskie, associate professor of comparative biology and experimental medicine at UCVM, and the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing.

https://www.ucalgary.ca/news/researchers-find-aging-stem-cells-have-key-role-hair-loss

Paper: https://www.sciencedirect.com/science/article/abs/pii/S1534580720302318?dgcid=author

 

[John Difool]

Well Doh. I wouldn't have thought about this. Seriously who are these puppets?

“If we ever want to prevent hair loss from happening or resurrect hair growth once you start to lose your hair, we need to focus on maintaining the function of these hair follicle dermal stem cells,” says Biernaskie

Hey Professor, you forgot to tell us how.

 

[cocona]

Hey Professor, you forgot to tell us how.

DHT blockers.

 

[John Difool]

Lol. For something new. People who take them tend to look younger anyway

 

[Trichosan]

If his theory is valid, it might be justification for starting to remove senescent cells at an earlier age. The anti-agers are using Dasatinib and Quercetin or Fisetin for such purposes.

 

[Capone]

If his theory is valid, it might be justification for starting to remove senescent cells at an earlier age. The anti-agers are using Dasatinib and Quercetin or Fisetin for such purposes.

Dasatinib? Severe sides incl heart failure lol

 

[Photon]

I've been on Dasatinib and Quercetin. It feels like you have a nasty fever for three days, but then you feel like new the next day. I didn't see any hair growth though. I've also used other longevity drugs but nothing noticable as far as hair is concerned.

If I had to try something newish - it would have to be NMN.

 

[Throwaway94]

I remember this guy, he published some of replicel's early studies on DSC cell injections in mice.

 

[John Difool]

I've been on Dasatinib and Quercetin. It feels like you have a nasty fever for three days, but then you feel like new the next day. I didn't see any hair growth though. I've also used other longevity drugs but nothing noticable as far as hair is concerned.

If I had to try something newish - it would have to be NMN.

I am following Dr Sinclair's regimen. Resveratol and NMN. No noticeable effects but how do you determine if you're still aging or not?

 

[ScentlessApprentice]

I am following Dr Sinclair's regimen. Resveratol and NMN. No noticeable effects but how do you determine if you're still aging or not?

I took the MyDNAage test before I started NR, Resv, and Berberine (metformin alternative). I'm 38 and my biological age is 39. Once I've taken these for 6 months, I'll retest to see if there is a difference. No noticeable results on hair.

 

[Photon]

I am following Dr Sinclair's regimen. Resveratol and NMN. No noticeable effects but how do you determine if you're still aging or not?

Yeah, I read his new book and his regimen seems promising.

Now that I remember, the most powerful thing you can take is rapamycin. There's research that suggest that at low doses and doing it intermittently, you can avoid the terrible side effects. But I can't find any of that, not until they calm with covid-19 China crap anyway.

 

[John Difool]

Very good.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/

 

[doflamingo]

You'll still be bald schmuks dont worry, cure in 5 years though

 

[FCKW36]

I've been on Dasatinib and Quercetin. It feels like you have a nasty fever for three days, but then you feel like new the next day. I didn't see any hair growth though. I've also used other longevity drugs but nothing noticable as far as hair is concerned.

If I had to try something newish - it would have to be NMN.

Isn't Quercetin highly cancerous?

 

[Photon]

Isn't Quercetin highly cancerous?

No clue where you heard that but from what I've read - it's harmless and not that potent tbh.

 

[Throwaway94]

Isn't Quercetin highly cancerous?

Nope

 

[John Difool]

I dropped quercetin a long time ago for some reason. I don't even remember why. I think because it inhibits b-catenin. That should make it anti-cancer, but not good for hair.

On the other hand, rapamycin seems to be good for hair regrowth.

 

[Squeegee 2.0]

If his theory is valid, it might be justification for starting to remove senescent cells at an earlier age. The anti-agers are using Dasatinib and Quercetin or Fisetin for such purposes.

All great senolytics.

 

[Squeegee 2.0]

I took the MyDNAage test before I started NR, Resv, and Berberine (metformin alternative). I'm 38 and my biological age is 39. Once I've taken these for 6 months, I'll retest to see if there is a difference. No noticeable results on hair.

Boosting Levels of NAD+ May Make Senescent Cells More Aggressively Inflammatory
https://www.fightaging.org/archives...nescent-cells-more-aggressively-inflammatory/

https://www.ncbi.nlm.nih.gov/pubmed/31140365

 

[Squeegee 2.0]

DHT blockers.

Androgen receptor drives cellular senescence.
https://www.ncbi.nlm.nih.gov/pubmed/22403609