Researchers Regrow Hair On Wounded Skin

[c_super2]

source:

https://medicalxpress.com/news/2018-11-regrow-hair-wounded-skin.html

 

[inmyhead]

https://www.hairlosstalk.com/intera...2-inhibits-wnt-signalling-hair-growth.118792/ same thread already exists.

 

[c_super2]

https://www.hairlosstalk.com/intera...2-inhibits-wnt-signalling-hair-growth.118792/ same thread already exists.

No, this is a different discovery from a different team from NYU. I promise. This one involves sonic hedgehog pathway.

 

[byebyehair]

source:

https://medicalxpress.com/news/2018-11-regrow-hair-wounded-skin.html

Credit: Wikipedia
Sorry that was the point where i stoped reading

 

[BetaBoy]

So if I'm reading this correctly, we can now rule out the proliferation of perifollicular fibrosis as a rate limiting factor on
AGΑ recovery.

 

[xetrys]

Credit: Wikipedia
Sorry that was the point where i stoped reading

Because they sourced an image from Wikipedia? Lol.

 

[PeggyPeterson]

https://www.nature.com/articles/s41467-018-07142-9

Here’s the real source. nature, the most prestigious journal in the world.

Meh.. only done on mice though.. I like the direction this is going though...

 

[JonnyGo]

I bet if i to

https://www.nature.com/articles/s41467-018-07142-9

Here’s the real source. nature, the most prestigious journal in the world.

Meh.. only done on mice though.. I like the direction this is going though...

Hmm isn’t this concept similar to microneedling wounding?

 

[Arrade]

So if I'm reading this correctly, we can now rule out the proliferation of perifollicular fibrosis as a rate limiting factor on
AGΑ recovery.

I think they are saying in normal wounded skin there is an issue, but the sonic pathway pushed through it...
Unless I missed something, I don't think we can dismiss perrifuclar fibrosis

 

[Arrade]

Also calling something the sonic the hedgehog pathway is very distracting

 

[PeggyPeterson]

This is different to microneedling, as it requires compounds to assist in signaling the body to regenerate new follicles..

Cotsarelis, the follica guy is one of the authors.. I really really really wanna know what the hell is happening with follica.. they’ve been quite opaque with there technology..

 

[BetaBoy]

I think they are saying in normal wounded skin there is an issue, but the sonic pathway pushed through it...
Unless I missed something, I don't think we can dismiss perrifuclar fibrosis

Ito says scientists have until now assumed that, as part of the healing process, scarring and collagen buildup in damaged skin were behind its inability to regrow hair "Now we know that it's a signaling issue in cells that are very active as we develop in the womb, but less so in mature skin cells as we age," she adds.

This conclusion is rejecting fibrosis as a rate limiting factor of hair growth no?

 

[PeggyPeterson]

https://www.ncbi.nlm.nih.gov/m/pubmed/29310861/

^^ potential is there.. if this stuff had more funding/money into research, we’d crack the MOFO.

 

[arnoldd]

Sorry guys someone can explain me this study ?

First says that hair doesnt growth on damagen skin because scarring and collagen buildup and than that hair regrowth occur after skin wounding ??
I don’t understand..

 

[Arrade]

This conclusion is rejecting fibrosis as a rate limiting factor of hair growth no?

It never states directly fibrosis. It could be fixing the fibrosis

 

[BetaBoy]

It never states directly fibrosis. It could be fixing the fibrosis

Scarring and collagen build up is fibrosis if I'm not mistaken

 

[bboy]

Research on the SHH pathway goes back like 20 years. There's short summary from Hairlosscure2020

https://www.hairlosscure2020.com/the-sonic-hedgehog-pathway-an-unrealized-dream/

It was so promising a company called Curis was step up in 2000 to commercialise a treatment that then partnered with Procter & Gamble in 2005. But the whole thing was scrapped in 2007 because of the potential risk of cancer. This study seems to be saying they may have found a way round this.

 

[PeggyPeterson]

Research on the SHH pathway goes back like 20 years. There's short summary from Hairlosscure2020

https://www.hairlosscure2020.com/the-sonic-hedgehog-pathway-an-unrealized-dream/

It was so promising a company called Curis was step up in 2000 to commercialise a treatment that then partnered with Procter & Gamble in 2005. But the whole thing was scrapped in 2007 because of the potential risk of cancer. This study seems to be saying they may have found a way round this.

Just WoW.. all this in 1999? What the f*** is wrong with these companies, surely they could’ve put money R&D to figure out a way to reduce cancer risk. It seems like all they do is completely drop viable solutions

 

[Arrade]

Scarring and collagen build up is fibrosis if I'm not mistaken

You are right. But we do not know from that study if it removed the fibrosis or not; it "changed" the wounded tissue.
The fact it completes wound healing sounds like ptd dbm

 

[BetaBoy]

You are right. But we do not know from that study if it removed the fibrosis or not; it "changed" the wounded tissue.
The fact it completes wound healing sounds like ptd dbm

No I’m saying and what I believe the reaserchers are implying is that fibrosis plays no factor in the restricting of HF growth.