Roxithromycin

[pelito]

Does any know something about this new products????

http://www.clinicaltrial.gov/ct/show/NC ... 79?order=1

http://www.ehrs.org/ocs/static.php?cf=1&id=5

thanks

 

[Goingat20]

i just finished a 5 day course of roxithromycin because i was feeling sick. Interesting to see if it could help hair loss in form of a lotion. Looks like im going to doctors to get my 2nd couse :lol:

 

[Guest]

what a f.... is this????

 

[docj077]

Figures.

People are finally starting to figure out that the problem in hair loss is not androgens, but the downstream molecules that these androgens produce.

This drug targets the release of TNF-alpha and proinflammatory cytokines, which basically shuts down the immune system wherever it touches.

The short and sweet is that this drug in a topical would be one of the finest drugs ever invented for hair loss as it would do more than just decrease hormones. It would prevent the process from ever occuring, which is something that a 5AR inhibitor can not do.

 

[pelito]

Hello I am a newbie from argentina, so sorry about my englis; my intention here is information, I always try to read this forum but I never post; one day I was reading another forum
http://foro.ganarpelo.org/viewtopic.php?t=12518
so i came here looking something about roxithromycin,
Thanks

 

[LostWind]

Figures.

People are finally starting to figure out that the problem in hair loss is not androgens, but the downstream molecules that these androgens produce.

This drug targets the release of TNF-alpha and proinflammatory cytokines, which basically shuts down the immune system wherever it touches.

The short and sweet is that this drug in a topical would be one of the finest drugs ever invented for hair loss as it would do more than just decrease hormones. It would prevent the process from ever occuring, which is something that a 5AR inhibitor can not do.

sounds good, how about getting the pills and making a topical?
pills will last a good while....

 

[docj077]

Figures.

People are finally starting to figure out that the problem in hair loss is not androgens, but the downstream molecules that these androgens produce.

This drug targets the release of TNF-alpha and proinflammatory cytokines, which basically shuts down the immune system wherever it touches.

The short and sweet is that this drug in a topical would be one of the finest drugs ever invented for hair loss as it would do more than just decrease hormones. It would prevent the process from ever occuring, which is something that a 5AR inhibitor can not do.

sounds good, how about getting the pills and making a topical?
pills will last a good while....

Sadly, I am poor and have no money. Only the internet sustains me.

 

[LostWind]

Figures.

People are finally starting to figure out that the problem in hair loss is not androgens, but the downstream molecules that these androgens produce.

This drug targets the release of TNF-alpha and proinflammatory cytokines, which basically shuts down the immune system wherever it touches.

The short and sweet is that this drug in a topical would be one of the finest drugs ever invented for hair loss as it would do more than just decrease hormones. It would prevent the process from ever occuring, which is something that a 5AR inhibitor can not do.

sounds good, how about getting the pills and making a topical?
pills will last a good while....

Sadly, I am poor and have no money. Only the internet sustains me.

I guess we gotta wait till the outcome of this trial, and see if it works..

 

[CCS]

http://en.wikipedia.org/wiki/Roxithromycin

Interesting how drugs traditionally used for something completely different also have effects on hair loss. I think pubmed studies are probably the only places that tell us spironolactone is an androgen receptor blocker.

In the link i just posted, it says Roxithromycin is an anti-biotic, is not metabolised much, and has a 12 hour half life.

 

[michael barry]

you can buy topical roxythromicyn from the experimental page at lipoxidil. I have a bottle of it.............man Im nosy when it comes to new treatments.

 

[Old Baldy]

The patent has run out on roxy. You can buy Rulid generic for pretty cheap. Shop around. At a rate of 0.5 percent it would be two 150mg. tablets in 60ml.

At that rate, a few strips of 10 tablets will last you a LONG time.

There are other generic names for roxy. also.

The problem with roxy. is that it has a high molecular weight. About 840. (Also, it's fat soluble btw.)

You can use d-limenone(sp?) according to the patent linked below as a penetration enhancer. Other basic penetration enhancers like oleic acid, DMSO and octyl salicylate might help? The patent likes liposomes.

Anyway for those interested in roxy. topical, this patent is a good read.

http://66.218.69.11/search/cache?p=roxi ... 1&.intl=us

 

[Old Baldy]

More info. on roxy.:

Roxithromycin

1.
Commercial product Name
Roxithromycin

2.
Chemical Name
(2R,3S,4S,5R,6R,8R,10R,11R,12R,13R)-5- (3,4,6- Trideoxy -3-dimethylamino- beta-D-xylo- hexopyranosyloxy) -3- (2,6-dideoxy-3-C- methyl-3- O-methyl- alpha-L-Ribo- hexopyranosyl oxy)- 13-ethyl-6,11,12- trihydroxy -2,4,6,8,10,12- hexamethyl-9-oxo tridecan- 13-olide, monostearate;

3.
CAS No.
643-22-1

4.
Empirical Formulae
C 37 H 67 NO 13 -C 18 H 36 O 2

5.
Molecular Weight
1018.59 (See my comment below.)

6.
Form
Fine white to off white powder

7.
Category
semi-synthetic antibiotic belonging to
the macrolide class .

8
Melting Point
100- 104 C

9.
Solubility in water
<1>=100 mg/mL at 22 C (in ethanol)

10.
Uses and Actions

The macrolides, derived from Streptomyces bacteria , are a group of antibiotics that inhibits protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. They are usually used for respiratory tract, skin, and genitourinary infections. Erythromycins inhibits protein synthesis in some microorganisms and are used as an antibiotic against many kinds of infections caused by gram-positive bacteria, including some beta-hemolytic streptococci, pneumococci and staphylococci as well as gram-negative bacteria and some fungi. It is used also in the treatment of upper and lower respiratory tract infections, infections caused by chlamydia trachomatis and intestinal amebiasis. It's application include the treatment of syphillis in patients who may be allergic to penicillin and the treating Legionnaire's disease.

Other sites list the molecular weight of roxy. at 840. This is the first I've seen where the MW is more than 840. :?

 

[Felk]

Is this being tested in a trial as a hair loss treatment, or did I misread somewhere?

 

[Old Baldy]

Yes Felk it is. Michael Barry posted info. on this a while back. I think the testing period is over in June of 2007.

(0.5 percent is being used in a minoxidil. type of vehicle IIRC.)

 

[Private Ryan]

will be getting some to try soon... will add about 0.5%-1% to my flutamide solution... hope it work fine with flutamide...

 

[Guest]

you can buy topical roxythromicyn from the experimental page at lipoxidil. I have a bottle of it.............man Im nosy when it comes to new treatments.

And whereon the site is that excactly?? couldnt find it!!!! :?

 

[Guest]

Where can i buy the cheapest possible pure liposomal topial and then add Roxithromycin tablets into that?? someone know??

 

[chuckfrasher]

http://en.wikipedia.org/wiki/Roxithromycin

Interesting how drugs traditionally used for something completely different also have effects on hair loss. I think pubmed studies are probably the only places that tell us spironolactone is an androgen receptor blocker.

In the link i just posted, it says Roxithromycin is an anti-biotic, is not metabolised much, and has a 12 hour half life.

I took oral spironolactone for about two years and switched to Proscar before Propecia came out. Oral spironolactone was scary. But can you imagine taking a powerful antibiotic like that for extended periods of time? It couldn't be a good thing.

 

[powersam]

info about adding this to minoxidil would be great. did i misread or is that what they are testing?

 

[docj077]

http://en.wikipedia.org/wiki/Roxithromycin

Interesting how drugs traditionally used for something completely different also have effects on hair loss. I think pubmed studies are probably the only places that tell us spironolactone is an androgen receptor blocker.

In the link i just posted, it says Roxithromycin is an anti-biotic, is not metabolised much, and has a 12 hour half life.

I took oral spironolactone for about two years and switched to Proscar before Propecia came out. Oral spironolactone was scary. But can you imagine taking a powerful antibiotic like that for extended periods of time? It couldn't be a good thing.

That's why they want to make a topical out of it.