Roxithromycin
1.
Commercial product Name
Roxithromycin
2.
Chemical Name
(2R,3S,4S,5R,6R,8R,10R,11R,12R,13R)-5- (3,4,6- Trideoxy -3-dimethylamino- beta-D-xylo- hexopyranosyloxy) -3- (2,6-dideoxy-3-C- methyl-3- O-methyl- alpha-L-Ribo- hexopyranosyl oxy)- 13-ethyl-6,11,12- trihydroxy -2,4,6,8,10,12- hexamethyl-9-oxo tridecan- 13-olide, monostearate;
3.
CAS No.
643-22-1
4.
Empirical Formulae
C 37 H 67 NO 13 -C 18 H 36 O 2
5.
Molecular Weight
1018.59 (See my comment below.)
6.
Form
Fine white to off white powder
7.
Category
semi-synthetic antibiotic belonging to
the macrolide class .
8
Melting Point
100- 104 C
9.
Solubility in water
<1>=100 mg/mL at 22 C (in ethanol)
10.
Uses and Actions
The macrolides, derived from Streptomyces bacteria , are a group of antibiotics that inhibits protein synthesis by bacteria at the 50S ribosome. They are characterized by a macrocyclic ring (a large ring molecule with many functional groups bonded to it) and a large lactone ring in the molecular structure. They are usually used for respiratory tract, skin, and genitourinary infections. Erythromycins inhibits protein synthesis in some microorganisms and are used as an antibiotic against many kinds of infections caused by gram-positive bacteria, including some beta-hemolytic streptococci, pneumococci and staphylococci as well as gram-negative bacteria and some fungi. It is used also in the treatment of upper and lower respiratory tract infections, infections caused by chlamydia trachomatis and intestinal amebiasis. It's application include the treatment of syphillis in patients who may be allergic to penicillin and the treating Legionnaire's disease.
