Scalp DHT vs. Serum DHT
- Thread starter mjk450
- Start date
mjk450 said:
Both finasteride and dutasteride block more serum DHT than scalp DHT.
Serum DHT is total circulating DHT in the body.
Scalp DHT is the concentration of DHT in the scalp. DHT is thought to be produced at various locations, including the scalp. This is where it matters most in my opinion, serum isn't important. Although we do have the added bonus of severely lowering our risk for prostate cancer.
Dutasteride restricts over 90% of DHT in the body, and around 50% in the scalp. I suspect results will vary greatly between people, thus determining efficacy. Body weight, metabolism, absorbtion etc. all play a role. Grapefruit juice apparently aids increased dutasteride absorbtion.
thanks for the reply! So if dutasteride does indeed decrease scalp DHT by 55% (@.5mg/daily). how do studies show regrowth? There is still 45% of the initial DHT in the scalp!
Although if dutasteride does decrease the total (serum) DHT by 90- this could be greatly impacting the concentration in all places, including the scalp. What the study may say (and I could be terribly wrong) is that DHT is reduced by 90% and of that remaining 10%, 55% of it is eliminated from the scalp. Thoughts?
Although if dutasteride does decrease the total (serum) DHT by 90- this could be greatly impacting the concentration in all places, including the scalp. What the study may say (and I could be terribly wrong) is that DHT is reduced by 90% and of that remaining 10%, 55% of it is eliminated from the scalp. Thoughts?
mjk450 said:
Regrowth occurs depending on the state the hair follicle is in, ie. how much minituarization has already occured. It's different for everyone, perhaps my hair follicles can regrow once 60% of the DHT is eliminated, and the follicle can withstand the remaining DHT levels and live for longer. For others they may need more DHT inhibition. This explains the variability in results. There is a threshold we all have before DHT no longer damages the follicle, and regrowth can occur. Note that AVERAGE scalp DHT reduction is around 50% for 0.5mg.
Of that 10% of SERUM DHT? Well the enzymes converting test to DHT exist at the follicular level too. Just what proportion of serum:follicular DHT is responsible for minituarization, I don't know.
