Seasonal Allergies

EasyEd

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Does anyone here have seasonal allergies (i.e. pollen, hayfever, etc)? If so, what do you use to treat it? I currently use Zyrtec, which has done well for me in the past, but it's been killing me for the past week, and I feel like I may need something stronger. Any recommendations?
 

The Gardener

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I've got the same thing, somewhat, and I was using Claritin ever since the days when it was a prescription drug and it worked reliably for me. I believe its available over the counter nowadays.

Another thing that seemed to help fight off the allergy symptoms, for me, is caffeine believe it or not.

I think I've "grown out" of my allergies as I've gotten older, they don't seem to hit me nearly as much as they used to in the past. Nowadays, and especially this time of year, when I start feeling wheezy or prickly in the nose and eyes, a cup or two of green tea seems to relieve it and I haven't used the Claritin in years.
 

beaner

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The stuff knocks me out, but I still think the best thing for allergies is good old Benadryl.
 

The Gardener

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Oh yeah, Benadryl is the shiznit... but like you say, its best used only in the PM.
 

oni

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kenalog injection...................................does the trick for my hay fever.......
 

decro435

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I've read a study that zyrtec could be a treatment for alopecia areata.
 

EasyEd

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I actually just did some research and found some people that said zyrtec causes hair loss. Anyone ever heard this?
 

decro435

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As devastating as Androgenetic Alopecia can be, the Autoimmune hair loss conditions, such as Alopecia Areata and Alopecia Universalis are cosmetically more catastrophic and much more difficult, if not impossible to manage. There are currently no reliable treatments for Alopecia Areata and Alopecia Universalis, and those afflicted can in most cases only hope for an unpredictably occurring spontaneous remission. It is said that the cure for most disease is in many cases right under our noses. Since there are no real treatments for Alopecia Areata as of yet, we felt compelled to feature this abstract in the hopes it be of use to someone. Because male pattern baldness, or Androgenetic Alopecia has an established and pronounced autoimmune component, there *may* be some crossover benefit for male pattern baldness as well.


Int Immunopharmacol. 2004 Mar;4(3):349-53.


Cetirizine and allopurinol as novel weapons against cellular autoimmune disorders.

Namazi MR

Dermatology Department, Shiraz University of Medical Sciences, P.O. Box 71955-687 Shiraz, Iran

Type 1, or cellular, immune response is characterized by overproduction of TNF-alpha, IFN-gamma, IL-1, IL-2 and IL-8 and is the underlying immune mechanism of psoriasis, alopecia areata, rheumatoid arthritis, Crohn's disease, multiple sclerosis, insulin-dependent diabetes mellitus and experimental autoimmune uveitis (EAU). Type 2 immune response is seen in antibody-mediated autoimmune diseases. Based on the pharmacokinetic effects of cetirizine and allopurinol, this paper introduces these two safe and inexpensive drugs as novel potential agents against cell-mediated autoimmune disorders. Cetirizine, supposed to inhibit DNA binding activity of NF-kappa B, inhibits the expression of adhesion molecules on immunocytes and endothelial cells and the production of IL-8 and LTB4, two potent chemoattractants, by immune cells. It induces the release of PGE2, a suppressor of antigen presentation and MHC class II expression, from monocyte/macrophages and reduces the number of tryptase positive mast cells in inflammation sites. Tryptase is a chemoattractant, generates kinins from kininogen, activates mast cells, triggers maturation of dendritic cells and stimulates the release of IL-8 from endothelial cells and the production of Th1 lymphokines by mononuclear immunocytes. Allopurinol is a free radical scavenger, suppresses the production of TNF-alpha and downregulates the expression of ICAM-1 and P2X(7) receptors on monocyte/macrophages. ICAM-1 serves as a ligand for LFA-1 (on T lymphocytes), allowing proper antigen presentation. P2X(7) receptors are thought to be involved in IL-1beta release, mitogenic stimulation of T lymphocytes and the probable cytoplasmic communication between macrophages and lymphocytes at inflammation sites. Allopurinol was markedly more effective than prednisolone in treating experimental autoimmune uveitis and in combination with cyclosporine suppressed the inflammatory reaction of this condition more effectively than either agent alone. As allopurinol is a competitive inhibitor of xanthine oxidase and decreases serum levels of uric acid, which is protective against multiple sclerosis, it should preferably be coadministered with uric acid precursors in the treatment of this condition. Cetirizine and allopurinol may prove of benefit in the treatment of various cellular autoimmune disorders.
 
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