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Selective Cox-2 inibitors for treating male pattern baldness
- Thread starter StayPositive
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Generational reproductive outcomes in Wistar rats maternally exposed to Ricinus communis oil at different stages of gestation - PubMed
Fetal programming hypothesis presupposes that stimulus or insult acting during critical periods of uterine growth and development may permanently alter tissue structure and function. Ricinus communis oil (RCO) has been reported to possess/used as laxative, labor-inducing and estrogenic...
pubmed.ncbi.nlm.nih.gov
Ricinus communis oil (RCO) has been reported to possess/used as laxative, labor-inducing and estrogenic properties. ...
At postnatal day 90, F1 males from the RCO-treated group showed significant decrease in testis weight, body weight, sperm count, motility and normal morphology. Testosterone levels were significantly decreased in RCO-treated F1 males, which also showed testicular interstitial edema and epididymal hypospermia. Only pubertal indexes were altered in F2 rats. Maternal exposure to RCO at early gestation periods impaired androgen-mediated reproductive end points in the first generation of rats. RCO exhibits endocrine disrupting capabilities.
Oral castor oil is not necessarily safe for your hormones, either. Ironically these so-called prostaglandin modulators end up working via the hormonal angle anyway, which is the very thing we try to avoid.
Even stimulating PGE2 may just be a roundabout way of inducing more aromatase:
Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes - PubMed
The aromatase enzyme complex, located primarily in the stromal cells of breast tumors, catalyzes estrogen biosynthesis and is fundamental to hormone-dependent growth of breast cancer. Although an important pharmacological target, the mechanisms by which aromatase is regulated are poorly...
pubmed.ncbi.nlm.nih.gov
Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells - PubMed
C19 steroids are converted to estrogens by aromatase P450 (P450arom). Aromatase expression in humans is regulated by use of tissue-specific promoters in the placenta (promoter I.1), adipose tissue (promoters I.4, I.3, and II), and gonads (promoter II). The use of each promoter gives rise to a...
pubmed.ncbi.nlm.nih.gov
It is hard to sidestep the fundamental issue of hormonal imbalance in the hair follicle. With the potential exception of antioxidants I haven't found anything else that works to any reasonable degree without affecting hormones.
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I did a lot of researches recently on cox inhibitors
I found all non selective cox inhibitors reduce serum testosterone and sperm count/mobility while selective Cox-2 inhibitors only have a negative effect on sperm count/mobility but do not affect serum testosterone level at all.
I found all non selective cox inhibitors reduce serum testosterone and sperm count/mobility while selective Cox-2 inhibitors only have a negative effect on sperm count/mobility but do not affect serum testosterone level at all.
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By the way, I just happened to find this while searching for Spirulina, a supplement I take occasionally. It's hard to make a topical out of, but it does seem to be what you're looking for:
www.researchgate.net
Selective Inhibition of Cyclooxygenase-2 by C-Phycocyanin, a Biliprotein from Spirulina platensis | Request PDF
Request PDF | Selective Inhibition of Cyclooxygenase-2 by C-Phycocyanin, a Biliprotein from Spirulina platensis | We report data from two related assay systems (isolated enzyme assays and whole blood assays) that C-phycocyanin a biliprotein from Spirulina... | Find, read and cite all the...
www.researchgate.net
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Hi man , since you have dupa like me , i want to know if aspirin is really working against dupa ? Is it worth to try ?Since starting my aspirin and oral castor oil protocol, i noticed a complete halt of my shedding in less than a month, NOTHING I TRIED IN THE PAST COULD DO THAT. This is the first time in 5 years my shedding stopped. That's why I am a big believer in Cox-2/Pgd2 pathway causing male pattern baldness
You can see my experiment on this protocol here : https://www.hairlosstalk.com/interact/threads/oral-castor-oil-and-oral-aspirin-combo.129039/
This is my problem : i am experiencing very low sex drive since starting the protocol. I did some research and find dozens and dozens studies showing aspirin greatly reduces serum testosterone. In fact it reduces testosterone synthesis by leydig cells.
Therefore i am looking for an alternative. And i think this alternative is a Cox-2 inhibitor. It's very surprising nobody tried selective Cox-2 inhibitors for hair loss in the past . A lot of people tried non selective cox inhibitors (cox1 and cox2) like diclofenac, indomethacin or ibuprofen, without results. Here is why:
1-We know from studies Cox-2 is overexpressed in the scalp of balding and bald men. We also know pgd2 is produced from cox2 and cause hair miniaturization.
2-These studies shows Cox-1 is the main Cox expressed in the dermal papilla , while Cox-2 is normally very little expressed, but we know that in balding men scalp, Cox-2 is very overexpressed. The study also shows that minoxidil benefits on hair from pge1 and pge2 come from upregulation of cox1.
Redirecting
linkinghub.elsevier.com
HMGB1 promotes hair growth via the modulation of prostaglandin metabolism - Scientific Reports
Unexpected hair growth can occur after tissue injury. The pathogenic mechanism for this phenomenon is unknown but is likely related to inflammatory mediators. One such mediator is high-mobility group box 1 (HMGB1), a ubiquitous nuclear protein that is released from cell nuclei after tissue...www.nature.com
So basically, in the scalp :
Cox 1 = Good = don't touch it
Cox 2 = Bad = destroy it
This is my theory : we need to reduce cox2 without reducing cox1. That's why people who tried non selective cox inhibitors alone (without pge2 analogs or cox1 upregulators like minoxidil) didn't get results.
I think topical cox2 inhibitor like celecoxib or etoricoxib should be very beneficial
What do you think?
abovedagame
Experienced Member
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What about topical salicylic acid?
abovedagame
Experienced Member
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Ah I see. Coal tar is a potent anti inflammatory. Can that help in any way?
abovedagame
Experienced Member
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No worries. Do you have any idea if ketoconazole affects cox enzymes in any way?
abovedagame
Experienced Member
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Jeez, it seems like most beneficial treatments affect the Cox 1 enzyme to some degree. That sucks because salicylic acid really helps with my scalp issues.
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Do you have solution against dupa ?
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Aspirin Found Effective for Erectile Dysfunction
Erectile function among men with vasculogenic erectile dysfunction improved significantly after 6 weeks of treatment with an aspirin dosage of 100 mg/day.
www.renalandurologynews.com
i found diff to explain this, if the reduce in testo and lh is significant.
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