I have been on a pretty extensive regime for about 2 years. Started with dutasteride .5 ed, then added spironolactone 100mg for about 1 year, recently added about 2 months ago-7.5mg of loniten which i decreased to 5 and now 2.5 mg ed. I have 0 sides from these meds but i also wouldn't recommend anyone take them without some lengthy research and insight to your own physiology. I possibly noticed increase HR on 7.5mg of Loniten but couldn't be sure it wasn't psychosomatic. Either way i decreased the dosage. I now have more hair then 6 or 7 years ago and i am getting comments that my hair is darker and longer. Some people are commenting that they have never seen me with more hair and honestly thought it was fake lol. Im not sure what is causing the thickening but i can probably cruise on 2.5mg of loniten and be fine same with 50-100mg spironolactone without any negative effects. Thought Id share my experience.