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Anti-aging small molecule PAPD5 inhibitor.
There's no real link with hair loss. But anti-aging always seems good and, who knows, might also help against hair loss.
Especially the small molecule thing is a plus for topical application.
Maybe a local effect might be possible this way.
Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.
Molecules identified that reverse cellular aging process
https://newatlas.com/medical/revers...ail&utm_term=0_65b67362bd-7ff5002a40-76691050
Here, we describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC). We identified BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.
https://www.sciencedirect.com/science/article/abs/pii/S1934590920301387
There's no real link with hair loss. But anti-aging always seems good and, who knows, might also help against hair loss.
Especially the small molecule thing is a plus for topical application.
Maybe a local effect might be possible this way.
Central to a lot of scientific research into aging are tiny caps on the ends of our chromosomes called telomeres. These protective sequences of DNA grow a little shorter each time a cell divides, but by intervening in this process, researchers hope to one day regulate the process of aging and the ill health effects it can bring. A Harvard team is now offering an exciting pathway forward, discovering a set of small molecules capable of restoring telomere length in mice.
Molecules identified that reverse cellular aging process
https://newatlas.com/medical/revers...ail&utm_term=0_65b67362bd-7ff5002a40-76691050
Here, we describe small-molecule PAPD5 inhibitors that demonstrate telomere restoration in vitro, in stem cell models, and in vivo. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC). We identified BCH001, a specific PAPD5 inhibitor that restored telomerase activity and telomere length in DC patient induced pluripotent stem cells.
https://www.sciencedirect.com/science/article/abs/pii/S1934590920301387
