- Reaction score
- 452
Based on the psuedohermaphodite studies, it is apparent that 5ar2 is primarily responsible for Androgenetic Alopecia.
Finasteride only inhibits type 2 and 3 while dutasteride inhibits type 1, 2, and 3. With dutasteride, you are inhibiting type 1 which seems to play little to no role in male pattern baldness while only inhibiting type 2 slightly more. This results in more T in scalp and only slightly less DHT where it matters in the hair follicle.
The T that was being funneled through the 5ar1 pathway which is persumably benign to the follicle for Androgenetic Alopecia purposes, is now free to bind with the receptors in the hair follicle.
In otherwords, if switching to dutasteride from finasteride gives you a 10% decrease of type 2 5AR reduced DHT (the DHT inside the follicle that progresses Androgenetic Alopecia)but a 50% + increase in scalp T (where it can freely interact with Androgen receptors inside follicle), the net effect could possibly be more androgenic in the hair follicle (these percentages are kind of arbitrary but the point is, small decrease in the 5AR type 2 reduced DHT that matters coupled with a very large T increase could result in more androgenic stimulation inside the follicle).
If one has high aromatase enzyme in the follicle, this may not be problematic and actually could be a benefit.
However, those that have high 5AR and low aromatase, it could possibly be detrimental and finasteride may be a better choice.
Thoughts?
Finasteride only inhibits type 2 and 3 while dutasteride inhibits type 1, 2, and 3. With dutasteride, you are inhibiting type 1 which seems to play little to no role in male pattern baldness while only inhibiting type 2 slightly more. This results in more T in scalp and only slightly less DHT where it matters in the hair follicle.
The T that was being funneled through the 5ar1 pathway which is persumably benign to the follicle for Androgenetic Alopecia purposes, is now free to bind with the receptors in the hair follicle.
In otherwords, if switching to dutasteride from finasteride gives you a 10% decrease of type 2 5AR reduced DHT (the DHT inside the follicle that progresses Androgenetic Alopecia)but a 50% + increase in scalp T (where it can freely interact with Androgen receptors inside follicle), the net effect could possibly be more androgenic in the hair follicle (these percentages are kind of arbitrary but the point is, small decrease in the 5AR type 2 reduced DHT that matters coupled with a very large T increase could result in more androgenic stimulation inside the follicle).
If one has high aromatase enzyme in the follicle, this may not be problematic and actually could be a benefit.
However, those that have high 5AR and low aromatase, it could possibly be detrimental and finasteride may be a better choice.
Thoughts?