spermidine

[JOHNNYBOOTS]

read about it on another forum,a italian study says it grows hair topically and orally.does anyone know anything about it?and is a product out there?

 

[slurms mackenzie]

read about it on another forum,a italian study says it grows hair topically and orally.does anyone know anything about it?and is a product out there?

http://www.iherb.com/Bell-Lifestyle-Sex ... ?at=hil335

It was with some trepidation that i did a search for spermadine and sources, there are two sources in which it is abundant, the one I'd choose is grapefruit.

<<edit>>

http://www.baldingblog.com/2009/04/10/g ... bsorption/

be careful if you're on the dutasteride though. Grapefruit juice is pretty well known for interfering with medications due to the way it reduces certain liver enzymes.

I spose there is another way :whistle:

 

[slurms mackenzie]

well done to those who guessed what i was thinking.

Yes, there's a chance you could up the levels of it's precursors

In mammalian cells, the ornithine forms putrescine by the action of the enzyme ornithine decarboxylase. Putrescine then forms spermidine and spermine through a reversible metabolic process

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022763/

 

[Jacob]

S. boulardii preparations contain high amounts of the polyamines spermadine and
spermine.

http://www.protherainc.com/images/prod/monographs/V776-06 Monograph.pdf

 

[Jacob]

http://www.nokomisresearch.com/eroxil.htm

Ingredients:

Polyamines 5 mg, selenium 100 mcg. Polyamines are naturally ocurring and found in such plant foods as oat, cucumber, and radish. Amines are essential elements for cellular and tissue growth and regeneration.

http://www.belllifestyleproducts.com//lp/eroxil-a-version.htm


Polyamines in foods: development of a food database:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022763/

 

[Jacob]

Seems like many of us have been using this all along(scroll way down):

Putrescine, Spermidine and Spermine are all poly-amines found in all plant cells. Both bind to the phosphate backbone of nucleic acids. The polyamines are crucial to cell migration, proliferation and differentiation in both plants and animals, so are tightly regulated within cells. Spermidine stimulates the enzyme T7-RNA polymerase. Spermine stabilises the helical structure of RNA, particularly of virii. Both Spermine and Spermidine were first discovered in human semen. Both are now used in skin-care beauty creams. Spermidine and Spermine are derivatives of Putrescine, which smells putrid and is excreted by cells as a means of discarding polyamines.

 

[Jacob]

Spermine, Spermidine and Putrescine: General
Polyamines play a major role in very basic genetic processes such as DNA synthesis and gene expression. Spermine and spermidine bind to the phosphate backbone of nucleic acids. This interaction is mostly based on electrostatic interactions between positively charged ammonium groups of the polyamines and the negatively charged phosphates of the nucleic acids.

Polyamines are key to cell migration, proliferation and differentiation in plants and animals. The metabolic levels of polyamines and amino acid precursors are critical and hence biosynthesis and degradation are tightly regulated.

Polyamines represent a group of plant growth hormones, but they also have an effect on skin, hair growth, female fertility, fat depots, pancreatic integrity and regenerative growth in mammals. In addition, spermine is an important reagent widely used to precipitate DNA in molecular biology protocols. Spermidine stimulates activity of T4 polynucleotide kinase and T7 RNA polymerase and is therefore used in protocols employing these enzymes.

Biosynthesis
Spermine and spermidine are derivatives of putrescine (1,4-diaminobutane) which is produced from L-ornithine by action of ODC (ornithine decarboxylase). L-ornithine is the product of L-arginine degradation by arginase.

Spermidine is a triamine structure that is produced by spermidine synthase (SpdS) which catalyzes monoalkylation of putrescine (1,4-diaminobutane) with decarboxylated S-adenosylmethionine (dcAdoMet) 3-aminopropyl donor. The formal alkylation of both amino groups of putrescine with the 3-aminopropyl donor yields the symmetrical tetraamine spermine.

The biosynthesis of spermine proceeds to spermidine by the effect of spermine synthase (SpmS) in the presence of dcAdoMet. The 3-aminopropyl donor (dcAdoMet) is derived from S-adenosylmethionine by sequential transformation of L-methionine by methionine adenosyltransferase followed by decarboxylation by AdoMetDC (S-adenosylmethionine decarboxylase).

Hence, putrescine, spermidine and spermine are metabolites derived from the amino acids L-arginine (L-ornithine, putrescine) and L-methionine (dcAdoMet, aminopropyl donor).

http://www.biosynth.com/index.asp?topic_id=162&g=19&m=205

Analysis of skin polyamines indicated that the syngenic mice tripled their spermidine content when exposed to promotion, whereas the transgenic animals showed only modest changes. These results suggest that putrescine plays a pivotal part in normal hair follicle development.

http://www.nature.com/jid/journal/v116/n5/abs/5601071a.html

 

[Sparky4444]

well, this is a real-deal study, for sure..

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022564

Someone is going to crack that barrier...I just wonder when...

 

[j87x]

Apparently spermidine destabilizes very quickly when added to a solution.

 

[Jacob]

That doesn't mean there's not a way around it though. Including possibly mixing up a bit of solution/topical right before applying it. Maybe stick your head in the freezer for an hour after applying.

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

http://www.sigmaaldrich.com/catalog/product/sigma/s2626?lang=en&region=US

 

[Born4Hair]

My Theory for this is. We have to programms for Life.

The one is for Reproduction and the seconde is for Long Life. If you look Androgenetic Alopecia is also a big part of Androgenetic Alopecia related.
With NRF 2 Pathway for Gen activation can switch on Longe live. If you dont in reproduction Mode (no sex, masturbation) the spermidine keeps in our Cells.
Some products like white grapefruit juice or wheatsprouts contains Spermindine.