Stem Cell Reproduction Problem Solved?

[Joxy]

With the new method, stem cells retained the stem cell-like nature for up to 51 days
A major obstacle in using human mesenchymal stem cells (hMSCs) to treat a variety of diseases has been successfully overcome by a team of researchers at the Indian Institute of Technology (IIT) Bombay. The team led by Dr. Abhijit Majumder from the institute’s Department of Chemical Engineering found hydrogel plate made of polyacrylamide was a perfect replacement for conventionally used plastic culture plates. Unlike the plastic plates, the hydrogel ensured that stem cells multiplied and retained the stem cell-like nature (stemness) for up to 51 days (20 generations) and differentiated into bone, cartilage or fat cells. The pre-print findings are reported in bioRxiv.

https://www.thehindu.com/sci-tech/s...n-stem-cell-proliferation/article24420355.ece

Maybe this can be beneficial for hair stem cells inductivity problem?

Abhijit Majumder profile:

https://www.che.iitb.ac.in/online/faculty/abhijit-majumder

 

[Hate da Bt]

With the new method, stem cells retained the stem cell-like nature for up to 51 days
A major obstacle in using human mesenchymal stem cells (hMSCs) to treat a variety of diseases has been successfully overcome by a team of researchers at the Indian Institute of Technology (IIT) Bombay. The team led by Dr. Abhijit Majumder from the institute’s Department of Chemical Engineering found hydrogel plate made of polyacrylamide was a perfect replacement for conventionally used plastic culture plates. Unlike the plastic plates, the hydrogel ensured that stem cells multiplied and retained the stem cell-like nature (stemness) for up to 51 days (20 generations) and differentiated into bone, cartilage or fat cells. The pre-print findings are reported in bioRxiv.

https://www.thehindu.com/sci-tech/s...n-stem-cell-proliferation/article24420355.ece

Maybe this can be beneficial for hair stem cells inductivity problem?

Abhijit Majumder profile:

https://www.che.iitb.ac.in/online/faculty/abhijit-majumder

Nice finding.
Thanks!

 

[Dhldan]

With the new method, stem cells retained the stem cell-like nature for up to 51 days
A major obstacle in using human mesenchymal stem cells (hMSCs) to treat a variety of diseases has been successfully overcome by a team of researchers at the Indian Institute of Technology (IIT) Bombay. The team led by Dr. Abhijit Majumder from the institute’s Department of Chemical Engineering found hydrogel plate made of polyacrylamide was a perfect replacement for conventionally used plastic culture plates. Unlike the plastic plates, the hydrogel ensured that stem cells multiplied and retained the stem cell-like nature (stemness) for up to 51 days (20 generations) and differentiated into bone, cartilage or fat cells. The pre-print findings are reported in bioRxiv.

https://www.thehindu.com/sci-tech/s...n-stem-cell-proliferation/article24420355.ece

Maybe this can be beneficial for hair stem cells inductivity problem?

Abhijit Majumder profile:

https://www.che.iitb.ac.in/online/faculty/abhijit-majumder

Interesting, stem cells are still effective (even if less) as long as their alive even without their stem cell- like nature though right? Hopefully they can prolong this even more.

 

[Hate da Bt]

Interesting, stem cells are still effective (even if less) as long as their alive even without their stem cell- like nature though right? Hopefully they can prolong this even more.

That's the main issue I have with RCH-01.
Are they using real stem cells or cells that used to be stem ones?

 

[soull]

That's the main issue I have with RCH-01.
Are they using real stem cells or cells that used to be stem ones?

Hello friend, do you think using real stem cells would return toform follicles? Or just improve the miniaturized hair?

Thank you!!

 

[bboy]

Hello friend, do you think using real stem cells would return toform follicles? Or just improve the miniaturized hair?

Thank you!!

We don't have to worry about this anymore. Creating new follicles is effectley a solved problem and the human trials start between 5 and 9 weeks from now.

But as far as I understand, the problem we had with multiplying the cells that form the hair follicle was they lost their ability to signal to the other cells just below the skin and kick start the process of growing a new follicle. The new culutring process these guys seem to be using seems to be quite like what researchers were doing to boost the signaling potential of cultured hair follicle cells, gels, 3d environments. But maybe it's something even better.

You also have to remember it's pretty unlikely you've lost the hair follicle, it's just probably very, very small.

 

[Hate da Bt]

Hello friend, do you think using real stem cells would return toform follicles? Or just improve the miniaturized hair?

Thank you!!

I highly doubt that extensive neogenesis would be achieved just by injecting loads of dp stem cells.
Nevertheless, I'm moderately confident that such injections may have a significant immunizing effect on existing hf.
No need to thank me, amigo mediterráneo.

 

[alibaba92]

That's the main issue I have with RCH-01.
Are they using real stem cells or cells that used to be stem ones?

Do they (Replicel / Shisedio) know whether the cells they are injecting is stem cells or non-stem cells ? Any method to determine this ?

 

[alibaba92]

I highly doubt that extensive neogenesis would be achieved just by injecting loads of dp stem cells.
Nevertheless, I'm moderately confident that such injections may have a significant immunizing effect on existing hf.
No need to thank me, amigo mediterráneo.

If a HF is immunized, would that HF de-miniatuzing over the time and return to the healthy normal state that they used to be ? Or would that HF stop miniatuzing and stay there at that size for the rest of their life ?

 

[Dhldan]

That's the main issue I have with RCH-01.
Are they using real stem cells or cells that used to be stem ones?

Yea I was thinking the same thing. It also seems like we’ll be needing injections much more frequently than I thought if rch-01 works.

 

[Dhldan]

Do they (Replicel / Shisedio) know whether the cells they are injecting is stem cells or non-stem cells ? Any method to determine this ?

I’m sure they do as they seem pretty competent, however the fact that they didnt release yet in Japan or announce when they’ll release leaves me suspecting if rch-01 is even effective. I don’t think rch-01 is going to be the next big TREATMENT, let alone cure. Not trying to upset everyone, but just my viewpoint considering they’re hesitant to inform us on anything + delayed the release/announcement one again.

If a HF is immunized, would that HF de-miniatuzing over the time and return to the healthy normal state that they used to be ? Or would that HF stop miniatuzing and stay there at that size for the rest of their life ?

If a hair follicle is alive, & injected to be immune to dht, some of the hairs would thicken overtime. If you want to grow all of them thicker than you’ll need a vasodilator (minoxidil) to encourage hair growth bc lowering dht from what we seen, only creates a good environment for regrowth. The follicles would need something to encourage growth after being attacked for so long & minaturized.

 

[yayapapaya]

Indian = 99% scam, doctored results.

 

[Joxy]

Indian = 99% scam, doctored results.

Slow down.

India is shithole in general, but look how many very good Indian scientists live and work in USA & Canada & UK.

Btw, this guy spend 2 years on Harward University in Boston and is part of Mumbai University.

 

[SuperDPAsteve]

Indian = 99% scam, doctored results.

Tempted to concur with this. Many Indian studies come out of the blue and directly contradict the conventional wisdom, in all fields - not just hair loss.

 

[Hate da Bt]

Do they (Replicel / Shisedio) know whether the cells they are injecting is stem cells or non-stem cells ? Any method to determine this ?

I don't know if they know, but they can very easily know. (See what I did there? Haha)
There are plenty of methods.

If a HF is immunized, would that HF de-miniatuzing over the time and return to the healthy normal state that they used to be ? Or would that HF stop miniatuzing and stay there at that size for the rest of their life ?

Yes, the hf would de-miniaturize gradually and restore its healthy state. Not all miniaturizing hf would undergo that, though. It should depend on the stage of miniaturization. The later stage, the lesser likelihood of restoration.

 

[BalderBaldyBald]

Yes, the hf would de-miniaturize gradually and restore its healthy state. Not all miniaturizing hf would undergo that, though. It should depend on the stage of miniaturization. The later stage, the lesser likelihood of restoration.

I'm curious about this point of no return you talked about, can you elaborate ?

 

[Hate da Bt]

I'm curious about this point of no return you talked about, can you elaborate ?

Do you speak Biology?
If not, I think it is pointless to elaborate.

 

[Dhldan]

I'm curious about this point of no return you talked about, can you elaborate ?

If the follicle thinned out/minaturized to the point where it would b very difficult to promote regrowth then the regrowth chances would be much lower. I personally believe if u use a vasodilator like minoxidil, lllt (if it even works), & potentially trinov then the hairs should be able to thicken.

This is NOT a guarantee however since we don’t understand male pattern baldness fully yet & surely dht isn’t the only factor.

 

[BalderBaldyBald]

Do you speak Biology?
If not, I think it is pointless to elaborate.

The f*** ? Instead of proving your point and maybe add some valuable insights with quotes, data and arguments to the board (and everyone), you just throw this douchy reply ?

Whatever, this forum is dying anyway, @InBeforeTheCure, @Noisette, where are you guys ?

 

[Hate da Bt]

The f*** ? Instead of proving your point and maybe add some valuable insights with quotes, data and arguments to the board (and everyone), you just throw this douchy reply ?

Whatever, this forum is dying anyway, @InBeforeTheCure, @Noisette, where are you guys ?

I guess, you don't.
It's sad that you can't just acknowledge that you are ignorant.