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I decided to do some research on stem cell based treatments in the last years.
The main reason to do so is to get a better feeling of the progress made towards a cure.
I will make a timeline with from my POV the most relevant information.
2009
Aderans Research Institute Inc. (ARI) recently announced the launch of its Phase 2 clinical study on cell-based hair regeneration in men and women. “The second phase of this study is another step in our efforts to truly understand the impact of regenerative cell therapy on pattern hair loss. It’s a tremendous opportunity,” said Kurt Stenn, MD, Vice President and Chief Scientific Officer. The research focuses on taking the two primary cell types within hair follicles – fibroblasts and keratinocytes – and promoting their growth in controlled laboratory environments before recombining them and inserting the “combined hair cells” in the patient’s skin, where they are expected to generate hair growth. (The Research was later shut down due to lack of funding)
fibroblasts and keratinocytes
PRP was a "new experimental" stem cell treatment.
from: https://www.beIgraviacentre.com/blog/stem-cell-hair-loss-treatment-in-the-making-169/
A leading expert on hair loss has said that hair cloning “should be available within three years”. Dr Akshay Batra, an Indian trichologist working in Dubai, believes that scientific developments mean that baldness will soon be cured in one operation and hair loss will be confined to the history books. The technique that Dr Batra is referring to involves removing a single strand of hair from the scalp and multiplying it into thousands of hair follicles that are reinserted into the scalp. “Initial results are good. This means that no man will ever be bald again,” says Dr Batra, “It should be out within three years”. (The difference to when the experts later will say the cure will be around in 2020 is that this claim about 3 years not give a clue who will have the cure or how it will work. The newer assumptions are more detailed and so in my POV more reliable)
from: https://www.beIgraviacentre.com/blog/cure-for-baldness-expert-says-hair-cloning-available-within-3-years-435/
2013
The Wnt pathway is important to hair regeneration, something first observed by researchers at the University of Pennsylvania in 2013.
from: https://www.beIgraviacentre.com/blog/clinical-trial-scheduled-for-regenerative-medicine-hair-loss-treatment/
2014
Billed as ‘the most advanced treatment for hair loss available’, stem cell transplants use autologous stem cells from fat, which can be safely harvested under local anaesthetic and are abundant in the body. These stem cells, once transplanted back into the patient, have the potential to repair not only hair follicles, but also to be used to repair connective tissues, bone, cartilage and more.
Rodrigo, who is 30 years old, noticed signs of male pattern hair loss – his hair thinning on top and receding at the temples – before deciding to go for the treatment.
He began to see results two months after treatment and says his hair is now “coming back in leaps and bounds,” explaining “the main results are on my temple, I don’t have a receding line anymore, I’m really happy with it all.” (Seems like the exact same thing HCell is doing in south corea.)
from: https://www.beIgraviacentre.com/blog/real-life-ken-doll-has-first-uk-stem-cell-hair-loss-treatment/
Investigating further, the University of Pennsylvania team discovered two more important facts. First, the stem cells required for new hair growth in the follicles of the scalp do not die off or disappear when Dkk1 takes effect – they merely become dormant.
To prove this, the researchers then removed Dkk1 from affected stem cells, restoring the Wnt/ß-catenin pathway. They then found that stem cells in the hair follicles were re-activated and that hair began growing normally once more.
https://www.beIgraviacentre.com/blog/new-potential-stem-cell-treatment-for-hair-loss-discovered/
2015
A study showes the benefit of adipose stem cells for hairloss.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379938/
January
Sanford-Burnham Medical Research Institute in California: A research team there reported in January that they were able to use human stem cells to grow hair in mice: their goal, of course, is to try the technology on humans. Current obstacles that stand in the way of this becoming a treatment option for people with hair loss include the inability (at present) to grow the hair in sufficient quantity – but it is nonetheless an encouraging starting point.
Experts state that hairloss is liekly cured by 2020 with stem cells if the problem of the amount of stem cells which can be produced is solved.
December
According to Global News Canada, researchers were able to identify the existence of skin stem cells in adult hair follicles that may one day be targeted to stimulate new hair growth.
from: https://www.beIgraviacentre.com/blog/research-round-up-latest-stem-cell-hair-loss-treatment-studies/
Replicell animal testing results:
Early animal trials of the stem-cell treatment showed excellent results; hair was grown where there were no follicles, plus where hair existed, it was thickened by the injections. (Seems better than the human results
)
2016
It is still belived that a stem cell therapy will be available by 2020.
Most promissing candidates
RCH-01 available 2018
Riken Human Trials in 2020 (I think now they talk about Human Trials in 2019)
The Sanford Burnham Prebys Medical Discovery Institute: (Dr. Alexey Terskikh) available unknown
The announcement suggests that plans to bring Riken’s technologies to market are gathering steam rapidly, as it was only in April of this year that the government-backed Riken announced that they had grown fully-functioning skin containing sweat glands and hair follicles for the first time. The news was welcomed as groundbreaking as it was a marked improvement on existing stem cell technologies which had thus far only created the outer layer of skin rather than the full organ.
Another stem cell-based treatment named Samumed SM04554 exploits the Wnt pathway and is currently undergoing clinical trials.
from https://www.beIgraviacentre.com/blog/clinical-trial-scheduled-for-regenerative-medicine-hair-loss-treatment/
Shiseidos rch-01 trial phase 2 started
The adipose stem cell treatment for hair is trailed in many countries. I wonder why there is such limited info on the trial results)
https://www.beIgraviacentre.com/blog/ongoing-south-korean-study-into-adipose-genetic-hair-loss-treatment/
They say that in tests on 12 people with “thin hair”, they were able to stimulate both terminal hair growth and a general thickening of existing hair using dalteparin/protamine nanoparticles, which can “effectively carry growth factors such as fibroblast.”
from: https://www.beIgraviacentre.com/blog/fibroblast-growth-factor-effective-in-treating-thinning-hair/
2017
Replicel phase 1 results are published.
https://replicel.com/20170314-2/
Kerastem Trial result of very small trial
Body fat solution injected into scalp
Those six volunteers saw a mean increase of 31 hairs per cm2 of scalp at 24 weeks, compared to baseline, which equated to an increase of 23 per cent. One or more of the subjects reportedly saw up to a 53 per cent increase – which naturally means that at leastone other subject had a growth rate somewhat lower than 23 per cent as well. The individual results have not been released at this time.
(That does kind of sound better than replicels results)
Interview with Dr Alexey Terskikh who still claims 2020 is possible with enough funding
from https://www.hairlosscure2020.com/category/alexey-terskikh/
2018
An interesting social experiment and a sad one
The methodology and findings of this social experiment replicate a similar oneundertaken on Tinder. Richard King, a 31-year-old from Leeds who had a hair transplant to address his Male Pattern Baldness, uploaded images of himself before and after the op: almost twice as many women wanted to date King based on his post-transplant profile.
from https://www.beIgraviacentre.com/blog/social-experiment-reveals-importance-of-hair-loss-when-dating/
The latest trial is being carried out by the Lebanese University in collaboration with Reviva Regenerative Medicine Center MEIH Hopsital and Reviva Pharmaceuticals. It will look into the effects of transplanting adipose-derived stromal vascular cells as a means to regrow hair in people with alopecia.
https://www.beIgraviacentre.com/blog/hair-loss-treatment-trial-for-adipose-derived-cell-transplants/
On Wednesday 5th July 2018 Medipost announced that it had acquired a patent for it in Japan, titled ‘Hair growth-promoting function of small-sized stem cells and use thereof’.
This follows a 28th February 2018 patent issued for the same treatment in Korea, entitled ‘Stimulated Stem Cell Culture Media’s Hair Growth Facilitating Function and its Use’.
According to Korea BioMed reports, a company spokesperson advised, “The patented technology proves that small mesenchymal stem cells isolated from umbilical cord blood or its culture have excellent hair loss prevention and hair growth promoting effect.”
from: https://www.beIgraviacentre.com/blog/medipost-developing-hair-loss-prevention-stem-cell-treatment/
Kerastem is undergoing a phase 2 trial in the usa
From: http://kerastem.com/product-pipeline/#home-before-after
Tsuji Treatment:
The need to develop an in vitro amplification method for epithelial stem cells and dermal papilla cells Previously, epithelial stem cells had not been identified, and it was known that the hair follicle regenerative capacity of cells disappears while cultured in vitro. However, we have overcome these problems with mouse and human cells after research activities over 7 years (This is a big step foreward)
from http://www.organ-technol.co.jp/uploads/2018/06/98a3d5caabf1c7829941ab2d5caf20f8.pdf
So all in all the understanding and approaches of stem cell related hairloss treatments has constantly improved. I hope my summarie shows that as well as my research showed that for me. In the last 3 years the a lot happened and there are so many players involved that showes that our problem is taken seriusly. If a cure will be out soon is not to be answered. But there are a lot of promissing aproaches out there and time will tell if and which will make it to the market.
Of course this list needs to be extended to get an better over all view so feel free to add important discoveries i forgot.
The main reason to do so is to get a better feeling of the progress made towards a cure.
I will make a timeline with from my POV the most relevant information.
2009
Aderans Research Institute Inc. (ARI) recently announced the launch of its Phase 2 clinical study on cell-based hair regeneration in men and women. “The second phase of this study is another step in our efforts to truly understand the impact of regenerative cell therapy on pattern hair loss. It’s a tremendous opportunity,” said Kurt Stenn, MD, Vice President and Chief Scientific Officer. The research focuses on taking the two primary cell types within hair follicles – fibroblasts and keratinocytes – and promoting their growth in controlled laboratory environments before recombining them and inserting the “combined hair cells” in the patient’s skin, where they are expected to generate hair growth. (The Research was later shut down due to lack of funding)
fibroblasts and keratinocytes
PRP was a "new experimental" stem cell treatment.
from: https://www.beIgraviacentre.com/blog/stem-cell-hair-loss-treatment-in-the-making-169/
A leading expert on hair loss has said that hair cloning “should be available within three years”. Dr Akshay Batra, an Indian trichologist working in Dubai, believes that scientific developments mean that baldness will soon be cured in one operation and hair loss will be confined to the history books. The technique that Dr Batra is referring to involves removing a single strand of hair from the scalp and multiplying it into thousands of hair follicles that are reinserted into the scalp. “Initial results are good. This means that no man will ever be bald again,” says Dr Batra, “It should be out within three years”. (The difference to when the experts later will say the cure will be around in 2020 is that this claim about 3 years not give a clue who will have the cure or how it will work. The newer assumptions are more detailed and so in my POV more reliable)
from: https://www.beIgraviacentre.com/blog/cure-for-baldness-expert-says-hair-cloning-available-within-3-years-435/
2013
The Wnt pathway is important to hair regeneration, something first observed by researchers at the University of Pennsylvania in 2013.
from: https://www.beIgraviacentre.com/blog/clinical-trial-scheduled-for-regenerative-medicine-hair-loss-treatment/
2014
Billed as ‘the most advanced treatment for hair loss available’, stem cell transplants use autologous stem cells from fat, which can be safely harvested under local anaesthetic and are abundant in the body. These stem cells, once transplanted back into the patient, have the potential to repair not only hair follicles, but also to be used to repair connective tissues, bone, cartilage and more.
Rodrigo, who is 30 years old, noticed signs of male pattern hair loss – his hair thinning on top and receding at the temples – before deciding to go for the treatment.
He began to see results two months after treatment and says his hair is now “coming back in leaps and bounds,” explaining “the main results are on my temple, I don’t have a receding line anymore, I’m really happy with it all.” (Seems like the exact same thing HCell is doing in south corea.)
from: https://www.beIgraviacentre.com/blog/real-life-ken-doll-has-first-uk-stem-cell-hair-loss-treatment/
Investigating further, the University of Pennsylvania team discovered two more important facts. First, the stem cells required for new hair growth in the follicles of the scalp do not die off or disappear when Dkk1 takes effect – they merely become dormant.
To prove this, the researchers then removed Dkk1 from affected stem cells, restoring the Wnt/ß-catenin pathway. They then found that stem cells in the hair follicles were re-activated and that hair began growing normally once more.
https://www.beIgraviacentre.com/blog/new-potential-stem-cell-treatment-for-hair-loss-discovered/
2015
A study showes the benefit of adipose stem cells for hairloss.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379938/
January
Sanford-Burnham Medical Research Institute in California: A research team there reported in January that they were able to use human stem cells to grow hair in mice: their goal, of course, is to try the technology on humans. Current obstacles that stand in the way of this becoming a treatment option for people with hair loss include the inability (at present) to grow the hair in sufficient quantity – but it is nonetheless an encouraging starting point.
Experts state that hairloss is liekly cured by 2020 with stem cells if the problem of the amount of stem cells which can be produced is solved.
December
According to Global News Canada, researchers were able to identify the existence of skin stem cells in adult hair follicles that may one day be targeted to stimulate new hair growth.
from: https://www.beIgraviacentre.com/blog/research-round-up-latest-stem-cell-hair-loss-treatment-studies/
Replicell animal testing results:
Early animal trials of the stem-cell treatment showed excellent results; hair was grown where there were no follicles, plus where hair existed, it was thickened by the injections. (Seems better than the human results
)2016
It is still belived that a stem cell therapy will be available by 2020.
Most promissing candidates
RCH-01 available 2018
Riken Human Trials in 2020 (I think now they talk about Human Trials in 2019)
The Sanford Burnham Prebys Medical Discovery Institute: (Dr. Alexey Terskikh) available unknown
The announcement suggests that plans to bring Riken’s technologies to market are gathering steam rapidly, as it was only in April of this year that the government-backed Riken announced that they had grown fully-functioning skin containing sweat glands and hair follicles for the first time. The news was welcomed as groundbreaking as it was a marked improvement on existing stem cell technologies which had thus far only created the outer layer of skin rather than the full organ.
Another stem cell-based treatment named Samumed SM04554 exploits the Wnt pathway and is currently undergoing clinical trials.
from https://www.beIgraviacentre.com/blog/clinical-trial-scheduled-for-regenerative-medicine-hair-loss-treatment/
Shiseidos rch-01 trial phase 2 started
The adipose stem cell treatment for hair is trailed in many countries. I wonder why there is such limited info on the trial results)
https://www.beIgraviacentre.com/blog/ongoing-south-korean-study-into-adipose-genetic-hair-loss-treatment/
They say that in tests on 12 people with “thin hair”, they were able to stimulate both terminal hair growth and a general thickening of existing hair using dalteparin/protamine nanoparticles, which can “effectively carry growth factors such as fibroblast.”
from: https://www.beIgraviacentre.com/blog/fibroblast-growth-factor-effective-in-treating-thinning-hair/
2017
Replicel phase 1 results are published.
https://replicel.com/20170314-2/
Kerastem Trial result of very small trial
Body fat solution injected into scalp
Those six volunteers saw a mean increase of 31 hairs per cm2 of scalp at 24 weeks, compared to baseline, which equated to an increase of 23 per cent. One or more of the subjects reportedly saw up to a 53 per cent increase – which naturally means that at leastone other subject had a growth rate somewhat lower than 23 per cent as well. The individual results have not been released at this time.
(That does kind of sound better than replicels results)
Interview with Dr Alexey Terskikh who still claims 2020 is possible with enough funding
from https://www.hairlosscure2020.com/category/alexey-terskikh/
2018
An interesting social experiment and a sad one
The methodology and findings of this social experiment replicate a similar oneundertaken on Tinder. Richard King, a 31-year-old from Leeds who had a hair transplant to address his Male Pattern Baldness, uploaded images of himself before and after the op: almost twice as many women wanted to date King based on his post-transplant profile.
from https://www.beIgraviacentre.com/blog/social-experiment-reveals-importance-of-hair-loss-when-dating/
The latest trial is being carried out by the Lebanese University in collaboration with Reviva Regenerative Medicine Center MEIH Hopsital and Reviva Pharmaceuticals. It will look into the effects of transplanting adipose-derived stromal vascular cells as a means to regrow hair in people with alopecia.
https://www.beIgraviacentre.com/blog/hair-loss-treatment-trial-for-adipose-derived-cell-transplants/
On Wednesday 5th July 2018 Medipost announced that it had acquired a patent for it in Japan, titled ‘Hair growth-promoting function of small-sized stem cells and use thereof’.
This follows a 28th February 2018 patent issued for the same treatment in Korea, entitled ‘Stimulated Stem Cell Culture Media’s Hair Growth Facilitating Function and its Use’.
According to Korea BioMed reports, a company spokesperson advised, “The patented technology proves that small mesenchymal stem cells isolated from umbilical cord blood or its culture have excellent hair loss prevention and hair growth promoting effect.”
from: https://www.beIgraviacentre.com/blog/medipost-developing-hair-loss-prevention-stem-cell-treatment/
Kerastem is undergoing a phase 2 trial in the usa
From: http://kerastem.com/product-pipeline/#home-before-after
Tsuji Treatment:
The need to develop an in vitro amplification method for epithelial stem cells and dermal papilla cells Previously, epithelial stem cells had not been identified, and it was known that the hair follicle regenerative capacity of cells disappears while cultured in vitro. However, we have overcome these problems with mouse and human cells after research activities over 7 years (This is a big step foreward)
from http://www.organ-technol.co.jp/uploads/2018/06/98a3d5caabf1c7829941ab2d5caf20f8.pdf
So all in all the understanding and approaches of stem cell related hairloss treatments has constantly improved. I hope my summarie shows that as well as my research showed that for me. In the last 3 years the a lot happened and there are so many players involved that showes that our problem is taken seriusly. If a cure will be out soon is not to be answered. But there are a lot of promissing aproaches out there and time will tell if and which will make it to the market.
Of course this list needs to be extended to get an better over all view so feel free to add important discoveries i forgot.
Last edited:
