Study on the effects of Vitamin E on PGE2

Folliman · Mar 24, 2016

http://carcin.oxfordjournals.org/content/27/11/2308.full.pdf

I haven't had time to read through but I thought I'd share it before I forget. It seems like a good read.

edit: tl;dr

phorbol induced PGE2 is inhibited by Alpha tocopheryl succinate

Alpha tocopherol and Alpha tocopheryl acetate had no effect on phorbol induced PGE2.

This study is also on human lungs. We don't know the effects of Vitamin E on endogenous PGE2 in the scalp, but could be similar.

mr_robot · Mar 28, 2016

Alpha-tocopherol succinate (Vitamin E Succinate/VES) is pretty potent stuff and inhibits NF-kB, you will find it is used in a lot of cancer research:

http://www.ncbi.nlm.nih.gov/pubmed/17262802

Treatment with alpha-tocopherol succinate (VES) inhibits NF-kappaB but augments AP-1 activity, reduces expression of IL-6, IL-8, and VEGF, suppresses cell adhesion, ICAM-1 and gp130 expression in androgen-independent PC-3, DU-145, and CA-HPV-10 cells. VES supplementation also decreases the expression of anti-apoptotic XIAP and Bcl-X(L) proteins and sensitizes androgen-dependent LNCaP cells to androgen deprivation.

Reducing IL-6 is good as IL-6 is shown to inhibit hair elongation (http://www.ncbi.nlm.nih.gov/pubmed/21881585) however reducing VEGF is bad as VEGF promotes formation of blood vessels.

PGE2 however is also a mixed bag as http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573344/

These results suggest that endogenous PGE[SUB]2[/SUB] regulates the production of IL-6, M-CSF, and VEGF by IL-1β-stimulated human synovial fibroblasts through the activation of EP[SUB]2[/SUB] and EP[SUB]4[/SUB] receptors with increase in cyclic AMP.

So increased PGE2 means more IL-6 but also more VEGF. Personally I don't believe PGE2 is the key as you can increase VEGF via hypoxia.