would it be more effective to take 1.25 mg twice a day every 8 hours than 1.25 once a day. If finasteride only has a half life of 4-8 hrs and there are 24hrs in a day wouldnt you be protecting against dht alot longer taking twice a day than once a day ? What are your thoughts?
Taking proscar 1.25 twice a day
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brian liles
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even though finasteride has a half life of 4-6 hours, that just means half of the medication is out of the boudy in that time frame. finasteride has tissue fixation, so its still remains on the tissues. therefor one dose is enough, and doind more than one dose will do no good. merck tested 80 mg of finasteride on some people and it yeilded the same results as 1mg. so 1mg a day is good enough
beaner
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The half-life of finasteride is completely irrelevant because a single dose lowers your DHT for more than 24 hours before it begins to slowly rise again. You only need to take it once a day and probably don't even need to take it that often for it to be effective.
I am 38 now and have been on finasteride for about 14 years. I am just thinking about ways to increase fins effectiveness since the drug has been loosing effectiveness. I bought some revivogen about a month ago but have not used it because it contains niacin in it and i am affraid it will raise pgd2. From what i understand Niacin raises pgd2 levels. I bought some s5 cream also and have not used it because people have said that it is not a very strong topical antiandrogen, and i have not seen any success stories. I am just getting really frustrated now and dont know what to do. Any advice would be appreciated Thnanks fellas.
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dam said:
Over and over and over on hairloss sites, somebody always mentions what you said above, so I'll continue to explain over and over and over: it takes a week or two for blood levels of DHT to get all the way back to "normal" after the last and final dose of finasteride, even though it has a relatively short half-life of only a few hours. Why? Because the limiting factor of what causes DHT to be formed in the body is how slowly the enzyme that produces it is produced. In other words, the half-life of finasteride itself doesn't have anything to do with it! Once the 5a-reductase enzyme is destroyed by finasteride, it's reproduced again by cells in our bodies so slowly that it takes a week or two for significant amounts of additional DHT to be produced!
See what I'm saying? Even if finasteride had a half-life of only a few MINUTES, it would still take a long time (a week or two) for new, "fresh" DHT to be prduced again, because that's how long it takes for 5a-reductase to be produced!
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ohmanohno said:
I don't know. There have been believable reports of guys taking finasteride tablets only once every two or three days while still apparently having a beneficial effect on their hair, but I don't know exactly how far you can push that general idea. I think it would probably be very risky to take it only once a week!
Thanks for your guys input. Thanks Bryan what you said makes sense, just wondering why do you think the drug wares off after years of use? is it my age or is my hair now more sensitive to androgens? Do you think revivogen would help me any or am i wasing my time and money? Maybe i need a strong antiandrogen. Any advice would be appreciated
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dam said:
I don't think finasteride "wears off" in the sense that you may be suggesting (that finasteride slowly loses its ability to inhibit 5a-reductase). I think balding gets worse as the years go by for the reason you stated in that one sentence above: I think scalp hair follicles slowly become more and more sensitive to androgens over time! About the only thing you can do to fight that is to add more items to your basic regimen; suppressing the production of DHT more completely by replacing finasteride with dutasteride would be an obvious thing to try, or adding topical antiandrogens; adding copper-peptides (there are several such products available, like Tricomin and Folligen), or other products which attack balding in several different ways. Sometimes you have to throw everything into the fight that you can!
WillNotLetItHappen
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On the Bernstein medical center page they suggest upping the dose to half a tablet of Proscar in case the drug loses effectiveness for you.
Even though DHT suppression of this additional amount is minimal, it may do the trick. I don't know, but at least they are more experienced than me.
Even though DHT suppression of this additional amount is minimal, it may do the trick. I don't know, but at least they are more experienced than me.
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Why do all that just to lose hair?