The current situation of male pattern baldness treatments

[farkhairloss]

2016 and all we have is finasteride and minoxidil. RU doesnt seem to work for long according to many.. Seti was hyped and now we dont hear much. Breezula results were poor.

Replicel and Histogen seem years away if they make it to market and honestly Replicel have shown nothing but theories.

Hairtransplants with limited donar still cause scaring no matter how much they improve there techniquies there is still not enough hair to give back your normal density. Hairlines never look 100% natural and anyone who says they do are full of it.

We have ole Artista still hyping Pillowfocus which again seems years away and unless it can produce donor regeneration is not really going to be much of a improvement.

PRP we all know is the biggest scam with SFA of proof. Now we have Joe Tillman who is a rep or whatever for Dr Cooley is now endorsing PRP. He has seen some pretty convincing pictures. Well perhaps he can share them with the rest of the world. We all remember Dr Cooley and his hype with acell. Again no cosmetic improvement pictures.

Then we have Spex who had FUE into his FUT scar years back to camouflage it. Now he is one of the reps or whatever for SMP (has been for a while) needs to get a second SMP into his scar to further camoflage it.

Then you have the hairtransplant doctors and there dodgy photos with poor lighting. Dr Ferudini who is supposedly one of the better doctors is a master of this. If you want to see some honest photos of hairtransplants. See hairtransplant network blog.. Most of these blogs are from normal people not affiliates of the transplant doctors.

Sad state of affairs, end of rant. Have I missed anything?

 

[Swoop]

 

[Pray The Bald Away]

If Follica, Shiseido, Riken, Fidia, and Samumed all fail then we are truly F'ed in the A. My optimism stems from the fact that all the big players are still in the game. I never had faith in Histogen.

 

[Rockinlove]

JAK inhibitors do espouse some potential for even androgenetic alopecia:

http://www.hairlosscure2020.com/category/jak-inhibitors/

However, hair transplant doctors and those engaged in other fields of research seem to downplaying any potential impact that it may have.

Then there is RISUG which is a male contraceptive and not a hair loss solution per se. However, the mechanism it employs could be used to delivery finasteride or dutasteride in the system in a more precise fashion and it would also be extremely cost effective. However, big pharma is not interested in exploring this possibility as it would delineate into lower profits.

Then there is beioengineered skin that can grow hair. I reckon that this is the most tenable solution for any form of alopecia.

Ergo, we are compelled to stick to expensive regimens as of now. It is a brave new world.

2016 and all we have is finasteride and minoxidil. RU doesnt seem to work for long according to many.. Seti was hyped and now we dont hear much. Breezula results were poor.

Replicel and Histogen seem years away if they make it to market and honestly Replicel have shown nothing but theories.

Hairtransplants with limited donar still cause scaring no matter how much they improve there techniquies there is still not enough hair to give back your normal density. Hairlines never look 100% natural and anyone who says they do are full of it.

We have ole Artista still hyping Pillowfocus which again seems years away and unless it can produce donor regeneration is not really going to be much of a improvement.

PRP we all know is the biggest scam with SFA of proof. Now we have Joe Tillman who is a rep or whatever for Dr Cooley is now endorsing PRP. He has seen some pretty convincing pictures. Well perhaps he can share them with the rest of the world. We all remember Dr Cooley and his hype with acell. Again no cosmetic improvement pictures.

Then we have Spex who had FUE into his FUT scar years back to camouflage it. Now he is one of the reps or whatever for SMP (has been for a while) needs to get a second SMP into his scar to further camoflage it.

Then you have the hairtransplant doctors and there dodgy photos with poor lighting. Dr Ferudini who is supposedly one of the better doctors is a master of this. If you want to see some honest photos of hairtransplants. See hairtransplant network blog.. Most of these blogs are from normal people not affiliates of the transplant doctors.

Sad state of affairs, end of rant. Have I missed anything?

 

[NorwoodGuardian]

I have read similar topic and content many times. Apart from misleading and spreading negative emotion, this type . post contribute nothing. Seems that you deliberately miss out the most promising ones to fulfill your purpose.
I can easily argue against your points with SM and Shiseido. Sm has shown regrowth in as short as three months and Shiseido has built a huge research centre in Kobe which means there must be something in the theory. And I don't think you can rule out Histogen which may come out in 2017 and Follica.

 

[Mach]

PRP we all know is the biggest scam with SFA of proof. Now we have Joe Tillman who is a rep or whatever for Dr Cooley is now endorsing PRP. He has seen some pretty convincing pictures. Well perhaps he can share them with the rest of the world. We all remember Dr Cooley and his hype with acell. Again no cosmetic improvement pictures

I've seen these photos. Stop in at Cooleys office. You'll change your tune. Most reputable Doctors have more to lose than gain coming to these forums.

 

[Pray The Bald Away]

I have read similar topic and content many times. Apart from misleading and spreading negative emotion, this type . post contribute nothing. Seems that you deliberately miss out the most promising ones to fulfill your purpose.
I can easily argue against your points with SM and Shiseido. Sm has shown regrowth in as short as three months and Shiseido has built a huge research centre in Kobe which means there must be something in the theory. And I don't think you can rule out Histogen which may come out in 2017 and Follica.

Yeah I noticed this too. There are a lot of very big companies that are working on treatments that he completely omitted. I'd argue the ones he left out are the ones that matter most.

 

[keep]

Garbage talk about hair transplants. There are reputable doctors in the industry... Rassman for example, who's honest. In Europe I've seen a lot of great pictures/videos of football players (soccer in US)/ celebrities, who had hair transplants and nobody would notice

 

[ItsGoing]

Says I need 4 posts to start a thread....I have nothing relevant to add

 

[IvanXproject]

2016 and all we have is finasteride and minoxidil. RU doesnt seem to work for long according to many.. Seti was hyped and now we dont hear much. Breezula results were poor.

Replicel and Histogen seem years away if they make it to market and honestly Replicel have shown nothing but theories.

Hairtransplants with limited donar still cause scaring no matter how much they improve there techniquies there is still not enough hair to give back your normal density. Hairlines never look 100% natural and anyone who says they do are full of it.

We have ole Artista still hyping Pillowfocus which again seems years away and unless it can produce donor regeneration is not really going to be much of a improvement.

PRP we all know is the biggest scam with SFA of proof. Now we have Joe Tillman who is a rep or whatever for Dr Cooley is now endorsing PRP. He has seen some pretty convincing pictures. Well perhaps he can share them with the rest of the world. We all remember Dr Cooley and his hype with acell. Again no cosmetic improvement pictures.

Then we have Spex who had FUE into his FUT scar years back to camouflage it. Now he is one of the reps or whatever for SMP (has been for a while) needs to get a second SMP into his scar to further camoflage it.

Then you have the hairtransplant doctors and there dodgy photos with poor lighting. Dr Ferudini who is supposedly one of the better doctors is a master of this. If you want to see some honest photos of hairtransplants. See hairtransplant network blog.. Most of these blogs are from normal people not affiliates of the transplant doctors.

Sad state of affairs, end of rant. Have I missed anything?

You are right. It's been 20 years since Propecia got approved by the FDA, and nothing has come out since.. All we ever hear is "5 more years" or "10 more years".. It is a shame.

 

[hellouser]

You are right. It's been 20 years since Propecia got approved by the FDA, and nothing has come out since.. All we ever hear is "5 more years" or "10 more years".. It is a shame.

We also have 'just shave it bro, it's just hair' after 20 years.

 

[MomoGee]

Am I the only one excited for Polichem's topical finasteride. Since it is supposedly as effectice as oral form but with much less systemic effects on the body, it will open up a massive door for those like me scared to try finasteride for that 1% chance (or whatever it is) of erectile dysfunction and other sexual problems. I understand that regrowth is the main problem now but we also need decent treatments for maintenance without sides.

 

[farkhairloss]

I have read similar topic and content many times. Apart from misleading and spreading negative emotion, this type . post contribute nothing. Seems that you deliberately miss out the most promising ones to fulfill your purpose.
I can easily argue against your points with SM and Shiseido. Sm has shown regrowth in as short as three months and Shiseido has built a huge research centre in Kobe which means there must be something in the theory. And I don't think you can rule out Histogen which may come out in 2017 and Follica.

I didnt deliberately leave anything out, it was getting late in my kneck of the woods when i posted, I thought I covered everything. Shiseido is using Replicels technology there phase 1 was a huge dissapointment which again was hyped before it came out. Actually SM is interesting there seems a little promise there but until we see some cosmetic improvement pictures..Histogen is the only company that have shown us some reasonable pictures, but if they were that promising why cant they get funding?

How many years has Follica been making claims for? Kerastem should we mention Ken Washenik whos supposedly had a cure 10 years ago. Finasteride has been trialed topically many times, is that the best we have to look forward to. And with regards to Dr Rassman I think he is one of the more honest Drs out there.

Sorry for such a negative post

 

[MomoGee]

How do you know that topical finasteride won't go systemic? Do you even know if finasteride can work locally? Even if they say it does, can you trust them? They still claim Propecia irreversible side effects aren't real. They claim that this drug is SAFE. And it's obviously not for some people.

I can't be too sure about it but from their own presentation "Apharmacokinetic phase I study, tested P-3074 b.i.d. vs oral finasteride 1 mg o.d., revealing a finasteride systemicexposure 15 times lower in the topical formulation".

Page 43 from: http://www.registration123.com/NAHRS/HAIR2015/media/pdf/AbstractBook_WCHR2015.pdf

I could only hope that this is the solution for me (Efficacy + No Sides), plus it should be here by early 2017 given that phase III had started late 2015.

Read more from: http://www.hairlosscure2020.com/encouraging-update-on-polichems-p-3074-topical-finasteride/

 

[IvanXproject]

The question is, will there be any new treatments in 2016?

 

[Pray The Bald Away]

The question is, will there be any new treatments in 2016?

The next promising treatment is slated for 2017.

 

[Pavi]

The next promising treatment is slated for 2017.

Italian treatment? Or histogen

 

[Pray The Bald Away]

Italian treatment? Or histogen

Fidia/Brotzu

 

[IvanXproject]

The next promising treatment is slated for 2017.

Man.. that is depressing.. Might as well stay away from this forum until 2017. And then maybe, only maybe, there will be a promising treatment

 

[Joxy]

Histogen news maybe...

2:15	Proteins Secreted by Hypoxia Induced Multipotent Stem Cells Stimulate Hair Growth in Men and Women
		Gail Naughton Chief Executive Officer Histogen
	Hair loss is associated with miniaturized hair follicles due to a variety of factors including hormones, chemicals, extensive heat, stress, and chemotherapy. Stimulation of telogen to anagen and subsequent hair growth involves Follistatin, FGF-7, VEGF, and other growth factors. Human fibroblasts, grown hypoxic suspension culture, revert back into multipotent stem cells within 48 hrs as evidenced by the upregulation of SOX 2, Oct4, NANOG, and KLF4 genes as well as the expression of stem cell-associated proteins including Nodal, Brachyry, Nestin, and Oct4. The multipotent stem cell conditioned media (CCM) was characterized by ELISA testing and shown to contain a number of key growth factors including Follistatin, Noggin, TGF beta1, FGF, VEGF and HGF, all of which are important in the normal hair growth cycle. We studied the effects of this human cell-derived formulation, termed Hair Stimulating Complex (HSC), in two double-blind, placebo-controlled trials in male pattern baldness. 26 subjects received four 0.1cc intradermal injections at baseline in our proof-of concept (POC) study. Trichoscan analysis of HSC-treated sites at 12 and 52 weeks showed improvements in hair growth over the placebo. At the 12-week evaluation period, HSC-treated sites demonstrated an increase in hair shaft thickness (6.3%±2.5% vs. -0.63%±2.1%; p=0.046), thickness density (12.8%±4.5% vs. -0.2%±2.9%; p=0.028), and terminal hair density (20.6±4.9% vs. 4.4±4.9%; p=0.029). At one year, an increase in total hair count (p=0.032) continued to be seen. Doubling the number and frequency of injections in a Phase I/II 56 subject study resulted in a 46.5% increase in total hair at week 12 as compared to the POC trial (p=0.0013). The primary efficacy endpoint of increased terminal hair at 12 weeks was met, with a 49.5% increase over the same endpoint in our proof-of-concept trial. At the 48 week time point there continued to be an increase in total hairs over baseline (p=0.028). Additional dose ranging clinical studies utilizing the isolated growth factors are being conducted to evaluate the safety and efficacy of this formulation in subjects with androgenetic alopecia. The CCM is also being studied in other applications where stimulation of endogenous stem cells may be of an aesthetic or therapeutic advantage. Source: https://www.gtcbio.com/conferences/stem-cell-product-development-commercialization-agenda

- - - Updated - - -

Histogen news maybe...

	Proteins Secreted by Hypoxia Induced Multipotent Stem Cells Stimulate Hair Growth in Men and Women
		Gail Naughton Chief Executive Officer Histogen
	Hair loss is associated with miniaturized hair follicles due to a variety of factors including hormones, chemicals, extensive heat, stress, and chemotherapy. Stimulation of telogen to anagen and subsequent hair growth involves Follistatin, FGF-7, VEGF, and other growth factors. Human fibroblasts, grown hypoxic suspension culture, revert back into multipotent stem cells within 48 hrs as evidenced by the upregulation of SOX 2, Oct4, NANOG, and KLF4 genes as well as the expression of stem cell-associated proteins including Nodal, Brachyry, Nestin, and Oct4. The multipotent stem cell conditioned media (CCM) was characterized by ELISA testing and shown to contain a number of key growth factors including Follistatin, Noggin, TGF beta1, FGF, VEGF and HGF, all of which are important in the normal hair growth cycle. We studied the effects of this human cell-derived formulation, termed Hair Stimulating Complex (HSC), in two double-blind, placebo-controlled trials in male pattern baldness. 26 subjects received four 0.1cc intradermal injections at baseline in our proof-of concept (POC) study. Trichoscan analysis of HSC-treated sites at 12 and 52 weeks showed improvements in hair growth over the placebo. At the 12-week evaluation period, HSC-treated sites demonstrated an increase in hair shaft thickness (6.3%±2.5% vs. -0.63%±2.1%; p=0.046), thickness density (12.8%±4.5% vs. -0.2%±2.9%; p=0.028), and terminal hair density (20.6±4.9% vs. 4.4±4.9%; p=0.029). At one year, an increase in total hair count (p=0.032) continued to be seen. Doubling the number and frequency of injections in a Phase I/II 56 subject study resulted in a 46.5% increase in total hair at week 12 as compared to the POC trial (p=0.0013). The primary efficacy endpoint of increased terminal hair at 12 weeks was met, with a 49.5% increase over the same endpoint in our proof-of-concept trial. At the 48 week time point there continued to be an increase in total hairs over baseline (p=0.028). Additional dose ranging clinical studies utilizing the isolated growth factors are being conducted to evaluate the safety and efficacy of this formulation in subjects with androgenetic alopecia. The CCM is also being studied in other applications where stimulation of endogenous stem cells may be of an aesthetic or therapeutic advantage. Source: https://www.gtcbio.com/conferences/stem-cell-product-development-commercialization-agenda