The Vitamin D Receptor, the Skin and Stem Cells.

vauxall

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http://www.ncbi.nlm.nih.gov/pubmed/20138991

J Steroid Biochem Mol Biol. 2010 Feb 4. [Epub ahead of print]

The Vitamin D Receptor, the Skin and Stem Cells.
Luderer HF, Demay MB.

Endocrine Unit Massachusetts General Hospital and Harvard Medical School, 50 Blossom St, Thier 11, Boston MA USA 02114.

The active metabolite of vitamin D, 1,25-dihydroxyvitamin D, has been shown to have pro-differentiation and anti-proliferative effects on keratinocytes, that are mediated by interactions with its nuclear receptor. Other cutaneous actions of the Vitamin D receptor have been brought to light by the cutaneous phenotype of humans and mice with non-functional vitamin D receptors. Although mice lacking functional vitamin D receptors develop a normal first coat of hair, they exhibit impaired cyclic regeneration of hair follicles that leads to the development of alopecia. Normal hair cycling involves reciprocal interactions between the dermal papilla and the epidermal keratinocyte. Studies in mice with targeted ablation of the Vitamin D receptor demonstrate that the abnormality in the hair cycle is due to a defect in the keratinocyte component of the hair follicle. Furthermore, expression of mutant Vitamin D receptor transgenes in the keratinocytes of Vitamin D receptor knockout mice demonstrates that the effects of the receptor that maintain hair follicle homeostasis are ligand-independent. Absence of a functional Vitamin D receptor leads to impaired function of keratinocyte stem cells, both in vivo and in vitro. This is manifested by impaired cyclic regeneration of the hair follicle, a decrease in bulge keratinocyte stem cells with ageing and an abnormality in lineage progression of these cells, leading to their preferential differentiation into sebocytes. Copyright © 2010. Published by Elsevier Ltd.

PMID: 20138991 [PubMed - as supplied by publisher]
 

michael barry

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Interesting stuff vauxall. Thanks for posting that.


Arison, nice avatar. Fish (salmon and sardines especially) are good sources of vitamin D.


I remember reading a while back an old experiment from the 1930's in which two men in the arctic attempted to eat a diet like the eskimos up there wer accustomed to, which is all-meat. One of the men noted that his hair growth was thicker during this time as a side effect. Neither man had any physical problems unless they eliminated the animal fat and ate only lean meat. The conclusion I drew is that animal fat, in the absence of carbohydrate, might have some of the nutrition folks on low-carb diets may need.



Seasonal-Affective-Disorder affects quite a few people who live in the far north during winter months and is characterised by folks not getting enough vitamin D. Vitamin D has a positive effect on our moods. Fish oil, whole milk, cold-water fish, 10 good minutes of real outdoor sunlight on exposed skin are all ways to get an adequate amount of vitamin D. Ive read that you can't manufacture vitamin D if the sunlight you are getting is through windows....
 

JLL

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Perhaps you're referring to this post on Stefansson and Andersen, the two arctic explorers?

No clinical evidence of vitamin or calcium deficiency was noted, despite the diet being both acidic and low in calcium. In addition, the mild gingivitis Stefansson had suffered from, cleared up entirely during the meat diet. Interestingly, Andersen reported that his hair stopped falling out shortly after the meat diet was started; Stefansson also noted his hair started growing thicker and his scalp was healthier.
 

michael barry

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That was it JLL. Those were the two guys. I seen that surfin' around the internet googling one night lookin' up stuff about various diets. Its neat stuff (to me). :)
 
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