Thoughts on prolactin

[sublime]

:woot:

 

[Guest]

This is nice Sublime.. It supports my theory in my previous thred about the apoptotis reaction is the "fundamental" reason for hair regretion..

http://www.hairlosstalk.com/discussions/viewtopic.php?t=26455

Keep up the good work as I think we are looking at the right level this time.. Downstream!!
So..this prolactin plays an important role in how hairfollicle cells behave..
The next question then would be something like.. "What drug will increase/decrease the amount of prolactin in the skin??"

Do we know anything about that?

PS...... PowerSam: Maybe I was not an "idiot" when talking about apoptosis after all.. :lol:

 

[sublime]

Chasteberry reduces prolactin levels but only with a decent dose. I don't know by how much but there are others experimenting with it. I am might give it a whirl in a couple months myself. When you reduce prolactin you will increase dopamine.

So far from what I have found is that prolactin is important in producing milk. Obviously this is not a functional concern for me in regard to my body. Also read that increased dopamine will increase sex drive and enjoyment.

Now what I am looking for is the downside of all of this, if there is any.

 

[Guest]

well sublime.. Interesting 4 sure
Dopamine is not recommended to mess to much around with as it is a neurotransmitter chemical..
I guess u know that the main effect of Cocain is high release of Dopamine in the blood giving the feeling of wellness when taking this lovely white powder :lol:

In small doses I would not believe this to be a big problem but in the long run maybe
I guess it will loose its effect gradually over time and you might feel a little empty inside when you choose to get off the stimulating drug..
But if it save some hairs and you get more happy about that I guess its worth a shot..
BUT... since it reduces prolactine levels and not targeting directly on the dopamine I guess it is much more safe than cocain or even other opiates and antidepressant drugs..
I've read some place that increased level of dopamine will decrease levels of prolactine and not that decreased levels of prolactine will increase level of dopamine as you say here.. Are u sure about this Sublime?? As I believe it a complete new scenario when it comes the long term side effect of the drug involved

There is really something about being happy and all off the other health benefits this state of mind has on the body in general.. So happiness is good because it protect the cells from apoptosis (speculative offcourse) This give this route some kinda Triple Effect:
1. Reduced hairloss due to decrease amount of cells going into apoptosis.
2. Increased level of happiness, energy and wellbeing due to increased levels of dopamine.
3. The other health benefits as an side-effect of being happy and feeling well in general.

Cool :hairy: I might look into this Chasteberry myself

Please keep us updated if you find more on this subject.. What about some topical prolactine inhibitor ?

 

[Guest]

Sublime: Why is this article about Chasteberry telling hairloss as #1/2 side-effect of this herb?? Am confused here now :wink:

"http://www.drugdigest.org/DD/DVH/HerbsCareful/0,3924,4094|Chasteberry,00.html"

I thought that decreased levels of prolactin would benefit hairs because the PubMed article says that high level of prolactin ( PRL ) would incease amount of cells going into apoptosis. So if this herb increase dopamine which decreases prolactin that is sayd to be bad for hairfollicles, then why is hairloss on the list of side-effect on Chasteberry.. This makes noooooooo sense to me. Or did i miss something here. .hmmmm
Or is it just like minoxidil,, causing the hair to go into catagen phase again-- Like some kinda reset button.. If this is the case we might have found the fundament of a new "cure"..

ahaaaa.. so this is the reason that almost all junkies still have their hair..
They all got this HUGE levels of dopamine in the body leave no room for prolactin to put the hair follicle cells into apoptosis..

I guess we need some feedback from some real scientists here!! hehe

 

[the_swami]

Interesting find Sublime. I would say that you should be careful trying to lower prolactin too much (see wikipedia link). A *safe* MAO-B inhibitor like selegiline would be a good choice to boost dopamine and lower prolactin gently (I take it myself for it's nootropic effects, it's also an antidepressant).

http://en.wikipedia.org/wiki/Prolactin

 

[sublime]

:x

 

[the_swami]

Swami - I read that wiki link before and was wondering what you are warning me about. Is it bulimia? :x

You're right, I got a backwards it seems. It looks like a elevated prolactin level is much worse than a low/normal level. I must have been sleepy or something.

 

[Guest]

The other sites I reviewed for chasteberry did not show hair loss at all. They also referenced the studies that the side effects were seen in. Now it was noted that small doses of chasteberry actually raise prolactin and this might be why that web site you listed noted hair loss as a side effect. A much larger dose does just the opposite and lowers prolactin. I will try to find out why it does this but it is just one of the interesting things about naturals and knowing the right amount to take.

Yeah.. please try to find out why it raise prolactin on small doses and what dose would be the most beneficial for the hair

 

[the_swami]

SSRIs, weight gain, hyperinsulinemia & increased prolact

This is an interesting article for anyone here who may be taking an SSRI and how it *may* (at least Paxil) effect prolactin and insulin.

http://www.netnutritionist.com/fa12.htm

The Relationship between Weight Gain and Medications for Depression and Seizures

"Paroxetine (Paxil®) appears to have the most significant impact on weight gain of all of the SSRIs. Studies show that patients using Paxil experience an increase in breast size as well as weight gain and increased serum prolactin."