Topadur Pharma's TOP-M119 & Eirion Therapeutics's ET-02 and ET-03

[1919]

[https://www.folliclethought.com/top...cs-new-hair-growth-gray-hair-cure-treatments/]

Forum has become a little gloomy with all the news dying down after the Tsuji hype. Anyways, heres some great news from FollicleThought to help you push through the tough days . So many new companies coming in should keep us all optimistic!
I also want to hear what the hair geeks on here have to say about these two companies.

Topadur​

TLDR; Topadur is a company that is working with the cGMP-enzyme regulation system to solve alopecia. Potentially much much stronger than minoxidil. Expected human clinical trials in 1-2 years. Pipeline: https://www.topadur.com/pipeline

"Sildenafil, the active ingredient in V.i.a.g.r.a, given topically stimulated the induction of the anagen phase in a mouse hair growth model. Since we had drug candidates which were much more potent than sildenafil and which in contrast to sildenafil also stimulated the production of cGMP we tested them in the same animal model and compared them with minoxidil. After one month we knew that we had something in hand that was more than 1000 times more potent, but also much more efficient compared to minoxidil. Next we tried the drug candidates in a chemotherapy induced hair stress model. And wow, we completely protected hair cells from cyclophosphamide induced toxicity. So we knew from then on, that we have something which is really very promising and offers help for many patients. Right now we are testing the potential of our drug candidate to protect the hair from several stress factor induced hair damaging.

Eirion​

TLDR; Topical ET-02 and oral ET-03's molecules are not yet revealed. Apparently involves "fixing" a dysfunction in hair follicle stemcell. "Eirion plans to launch its first clinical trial of ET-02 next year." "Secured $40M investment and licensing deal with the Shanghai Haohai Biological Technology."
Press release: https://practicaldermatology.com/ne...al-with-shanghai-haohai-biological-technology

One of the most interesting new companies that we have seen in years, Eirion Therapeutics of Woburn, Massachusetts, burst onto the scene this month with the announcement of a $40M investment and licensing deal with the Shanghai Haohai Biological Technology company of China. Eirion Therapeutics is an self-described aesthetic dermatology company with treatments in development for crow’s feet, excessive perspiration, androgenic alopecia, and hair graying. Interestingly, the company is developing both topical (ET-02) and oral (ET-03) versions of the same molecule (undisclosed at this time) for both hair growth and gray hair reversal.

“Eirion’s pre-clinical product candidates ET-02 and ET-03, which contain the same small molecule, employ a brand-new mechanism of action which corrects an aging defect in the hair follicle stem cells that Eirion has discovered causes androgenic alopecia and hair greying. Eirion believes that ET-02 and ET-03 can either prevent the defect from occurring or reverse the defect which would result in either new hair growth in those who have lost hair or the return of hair color for those who have turned grey.
In controlled non-clinical studies of human scalp tissue affected by androgenic alopecia, ET-02 demonstrated approximately twice the hair growth compared to a control treatment over approximately 4 months, which was statistically significant, and amounted to approximately three times the hair growth per centimeter over that which was observed in minoxidil clinical trials that were 12 months in duration. Eirion plans to launch its first clinical trial of ET-02 next year.”

Erion's claimed mechanism (not yet revealed):
"Eirion utilizes a different therapeutic approach than other products for androgenic alopecia that are commercially available or in development. ET-02 and ET-03 targets a novel and compelling mechanism of action that we believe corrects a dysfunction in the hair follicle stem cell that is the cause of alopecia."

 

[jan_miezda]

This pathway has a role in cancer prevention


The cyclic GMP (cGMP)/protein Kinase G (PKG) cascade is recognized as an endogenous apoptotic pathway in a number of cancer types, particularly breast and colon [5–10]. Cyclic GMP is generated from GTP by two distinct guanylate cyclase (GC) types. Particulate GCs (pGCs) are transmembrane receptors for natriuretic peptides, while soluble GC (sGC) is a cytosolic enzyme [11,12] that serves as a receptor for nitric oxide (NO), a cell permeable second messenger. Once produced, cGMP can be rapidly hydrolyzed by cyclic nucleotide phosphodiesterases (PDEs), a superfamily of 12 members that differ in structure, catalytic properties, and subcellular localization [13]. The PDEs are grouped into three classes: PDE4, 7 and 8 that hydrolyze cAMP, PDE5, 6, and 9 that break down cGMP, and the remainder have dual activity. The main downstream effectors of cGMP are two serine-threonine kinases, PKG-I and PKG-II, which share a number of targets with protein kinase A (PKA), while others are distinct [14].

Several drugs which increase intracellular cGMP are approved for treatment of nonmalignant conditions. For example, selective PDE5 inhibitors such as Tadalafil (Cialis), Sildenafil (v****) and Vardenafil (Levitra) are used to treat erectile dysfunction [15]. Sodium nitroprusside (SNP), a nitric oxide donor, is used as an acute vasodilator [16], while Riociguat, an NO-independent sGC stimulator, is approved for the treatment of pulmonary hypertension [17]. There is significant potential for repurposing these drugs as antineoplastic agents in many cancers.

 

[Dimitri001]

ET-02 demonstrated approximately twice the hair growth compared to a control treatment over approximately 4 months, which was statistically significant, and amounted to approximately three times the hair growth per centimeter over that which was observed in minoxidil clinical trials that were 12 months in duration.

Let me get this straight, the treatment performed twice as well as nothing and three times as well as minoxidil? I'm no mathematician...

Or does control TREATMENT mean the control was not a placebo? If it's not a placebo and not minoxidil, what was it? Finasteride? I don't know you put a control group on something with such potentially significant sides, but if it beat minoxidil, I guess it's gotta be finasteride.

 

[Jakejr]

Always knew a big pecker goes with big hair.
Going to put v**** on my head..