Topical Dutasteride - how to make one

[Fbalding84]

I know we have a couple chemists/pharmasists on the forum. Living in California means no access to 95% ethanol/ everclear we have to use other vehicles. And NO I do not want to use minoxidil.

I usually just take a toothpick puncture the gelcap and drain the liquid in a small container.

Question 1: what would be the best vehicle to use with the liquid 0.5mg gel caps.?

Questions 2: would isopropyl alcohol or vesapro cream work?

Question 3: since DHT is locally sythesized sebum gland. Will the liquid dutasteride+vehicle penetrate all the skin layers and reach where it needs to go?

Dutasteride stays in the blood around 5 weeks when taking orally but since it will be topical (some will go systemic but im refering to present locally in SGland) it might be different. As we know it does not bind to the androgen receptor (unlike ru/spironolactone) but inhibits both types of enzym that converts T toDHT.

Question 4: how often do we have to apply it?

 

[Thinning Sucks]

Definately goes systemic - I used to get pains tacking orally stopped went away then decided to mix two gel caps in minoxidil bottle and the pains came back. Tried this multiple stoppages and always came back.

 

[Fbalding84]

What percentage were you applying

 

[frenchy]

what is the point, though topical dht go systemic?

 

[Fbalding84]

Yes within the first 2min of application of scalp with the proper penetrating vehicle everything goes systems. Just Google the study scalp application might be alternative to oral meds. we just don't know how much is going to go systemic and affect blood DHT. My main concern is that since DHT is locally procudes at the hair follicle it's need to be target there.

Like one poster mentioned in a different forum. You don't solve someones glaucoma by giving them blood pressure medication. Blood level DHT is not the problem -it's the sensitive to DHT by follicle to DHT produced perhaps locally.

The reason why I believe the right mixture of meds applied topically will work. We just need to find how to get the Dutasteride(how much and hiw often) to the sebum gland have it inhibit the enzym responsible m, have reduced DHT to prevent the follicle from miniaturizing.

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what is the point, though topical dht go systemic?

Same Goes with minixodil if it wasn't goig systemic how would you explain the sides like dark circles under the eyes?

 

[frenchy]

yeah it does, but i wonder the point of taking dutasteride topically insted of orraly since it shouldn't be to avoid sides cauz it wouldn't

 

[minoxiDjunkie]

Question is - would it work or just cost you money ?

 

[Fbalding84]

The whole idea is that DHT sythesis at follicle level is going to be reduced. So some might go systemic but we don't know how much and what how significant the sides are. It seems people that apply it topical have great results and no sides almost (meaning follicle level DHT is reduced and minimum has gone systemic).

The key is to figure out proper penetration rates into the sebum gland and proper dosage/frequency required for optimal result

 

[minoxiDjunkie]

The whole idea is that DHT sythesis at follicle level is going to be reduced. So some might go systemic but we don't know how much and what how significant the sides are. It seems people that apply it topical have great results and no sides almost (meaning follicle level DHT is reduced and minimum has gone systemic).

The key is to figure out proper penetration rates into the sebum gland and proper dosage/frequency required for optimal result

what people ?

 

[Fbalding84]

Google or check other hairloss forums for topical finasteride/dutasteride

Brazilian thread, bald truth (last year) etc. studies

 

[minoxiDjunkie]

Maybe dmi ?