Topical dutasteride.

pratc

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A couple of people have said they use a topical form of dutasteride. I was wondering if they made there own or purchased it. I have seen a 'recipe' that says half a capsule with 35g of pure aloe gel. This is rubbed in fror 2 or 3 min after a shower.

There have been discussions regarding frequency of useage and the following may be ofinterst to some.

"The durability of the dutasteride molecule brings up another interesting aspect that you might all want to consider as well. I read an exchange between a group of doctors and questioners on another hair loss web site in which the patients were directly challenging the doctors as to whether there was really a need to use Avodart every day since the half life was 230+ hours. That meant the drug was really going to be there doing it's job for about 3 weeks, and that it would far less expensive to take Avodart maybe only every few days or once per week and still get the same results. The doctors at first rejected this idea with a brush-off kind of answer, but after some of the questioners told them they were full of crap the doctors recanted and suggested that users could go with a lower dosage each day. After further ridicule the doctors finally gave in and agreed with the conclusion, and even made a specific statement that scientifically speaking, one Avodart every 4 days would in fact produce the same results due to the extremely long half-life, and it would be a lot less expensive for the users.

Of course there were follow-up comments that this is probably why Glaxo halted the tests for Avodart as a hair loss drug, since people would discover they could take far less of this super-durable drug and get better results than with Propecia (with its half life of only 6 hours), which Glaxo is currently selling for about $2/day per user. So releasing Avodart as an official hair loss drug would potentially create a substantial loss of recurring revenue for the company. In other words, their new drug is too good".
 

CCS

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you are WAY off.

Avodart only has a long half life at high doses. If you take a capsule every 2 weeks you will lose hair just as fast as the placebo group. Even if you take a capsule every 5 days, it would take a month before you start getting the same protection that finasteride gives you.

Dutasteride doses are smaller than finasteride doses because of the long half life, but that means it takes longer to get to steady state, unless you do a loading dose.

if you use topical dutasteride, you are taking a risk of it not working. it is all self made.
 

pratc

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Glad you know the facts, collegechemistrystudent. I got that info. straight from an internet site. It wasn't my own ideas. Just goes to show that there is so much mis-information out there!

Edit: Do you know if people make the topical with aloe gel (as mentioned), or with an alcohol as a solvent?
 

Bryan

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pratc said:
There have been discussions regarding frequency of useage and the following may be ofinterst to some.

"The durability of the dutasteride molecule brings up another interesting aspect that you might all want to consider as well. I read an exchange between a group of doctors and questioners on another hair loss web site in which the patients were directly challenging the doctors as to whether there was really a need to use Avodart every day since the half life was 230+ hours. That meant the drug was really going to be there doing it's job for about 3 weeks, and that it would far less expensive to take Avodart maybe only every few days or once per week and still get the same results. The doctors at first rejected this idea with a brush-off kind of answer, but after some of the questioners told them they were full of crap the doctors recanted and suggested that users could go with a lower dosage each day. After further ridicule the doctors finally gave in and agreed with the conclusion, and even made a specific statement that scientifically speaking, one Avodart every 4 days would in fact produce the same results due to the extremely long half-life, and it would be a lot less expensive for the users.

OH NO!! Please, God, not THAT old chestnut again!! :D It doesn't work that way, and this is something I've been trying to get across to people literally for years on various hairloss sites, ever since Avodart first came out.

You can't "beat the system" by taking one larger dose of dutasteride every few days, and expect it to work the same way as taking that same larger dose EVERY day. The drug builds-up in your system, so the bottom-line effectiveness is determined by the AVERAGE amount in your bloodstream, as measured over a period of a few weeks. In other words, as the wise man once said, "There's no free lunch!" :wink:

The following dosing schemes all have the same effectiveness, because they all maintain the same AVERAGE level of drug intake, even though the drug is taken at different time intervals:

0.25 mg, twice a day
0.5 mg, once a day
1.0 mg, every other day
2.0 mg, every 4 days
3.5 mg, once a week
7.0 mg, once every 2 weeks
15 mg, once a month

Do you see what I'm saying? The AVERAGE daily dose is the same with all the above dosing schemes, even though the dosing intervals are different. That's all that matters. You can't take 3.5 mg/week (for example), and expect it to have the same effect as taking 3.5 mg/day. It won't. The half-life doesn't have a damned thing to do with it.

Bryan
 

Bryan

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pratc said:
I got that info. straight from an internet site. It wasn't my own ideas. Just goes to show that there is so much mis-information out there!

Please tell me what Web site you got all that crap from. I will _personally_ go there and pound them all into submission! :) It's time everybody learns at least the basics of how dutasteride works.

Bryan
 

pratc

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Bryan, I wish I could tell you but since getting that info. the temp folders and history have been cleared. I was just trawling looking for info about dutasteride.
Do you know or could you point me to where I can fine the result for 0.05mg testing with regards to suppression. I read somewhere that 0.5mg gives 90% suppression and was wondering how this falls off with lower doses. The 0.05 and 0.01mg were tested by the company at the same time.

The REAL knowledge on this form is excellent.

Thanks.
 

Harie

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Couldn't you just add dutasteride to Dermovan instead of mixing with aloe? The aloe I have dries in a couple of min, so the dutasteride couldn't be absorbed by the follicles in that time. For topical finasteride or dutasteride, you need a carrier that doesn't dry for a few hours.

Even minoxidil dries too quickly, though, if you added a ml or 2 more oil (flax seed oil is cheap), you could probably use minoxidil too.
 

Old Baldy

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Bryan said:
pratc said:
There have been discussions regarding frequency of useage and the following may be ofinterst to some.

"The durability of the dutasteride molecule brings up another interesting aspect that you might all want to consider as well. I read an exchange between a group of doctors and questioners on another hair loss web site in which the patients were directly challenging the doctors as to whether there was really a need to use Avodart every day since the half life was 230+ hours. That meant the drug was really going to be there doing it's job for about 3 weeks, and that it would far less expensive to take Avodart maybe only every few days or once per week and still get the same results. The doctors at first rejected this idea with a brush-off kind of answer, but after some of the questioners told them they were full of crap the doctors recanted and suggested that users could go with a lower dosage each day. After further ridicule the doctors finally gave in and agreed with the conclusion, and even made a specific statement that scientifically speaking, one Avodart every 4 days would in fact produce the same results due to the extremely long half-life, and it would be a lot less expensive for the users.

OH NO!! Please, God, not THAT old chestnut again!! :D It doesn't work that way, and this is something I've been trying to get across to people literally for years on various hairloss sites, ever since Avodart first came out.

You can't "beat the system" by taking one larger dose of dutasteride every few days, and expect it to work the same way as taking that same larger dose EVERY day. The drug builds-up in your system, so the bottom-line effectiveness is determined by the AVERAGE amount in your bloodstream, as measured over a period of a few weeks. In other words, as the wise man once said, "There's no free lunch!" :wink:

The following dosing schemes all have the same effectiveness, because they all maintain the same AVERAGE level of drug intake, even though the drug is taken at different time intervals:

0.25 mg, twice a day
0.5 mg, once a day
1.0 mg, every other day
2.0 mg, every 4 days
3.5 mg, once a week
7.0 mg, once every 2 weeks
15 mg, once a month

Do you see what I'm saying? The AVERAGE daily dose is the same with all the above dosing schemes, even though the dosing intervals are different. That's all that matters. You can't take 3.5 mg/week (for example), and expect it to have the same effect as taking 3.5 mg/day. It won't. The half-life doesn't have a damned thing to do with it.

Bryan

Bryan: After you reach steady state, can you take 60mg. of dutasteride. every four months and still have the protection you had at the beginning of the 4 months? :wink:
 
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