University Of Penn Discovers Dickkopf 2 (dkk2) Inhibits Wnt Signalling/hair Growth
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Does anyone have a link to the paper itself?
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The protein is called Dickkopf?
It sounds like an april fool to me as a german.
Dickkopf=bighead
It sounds like an april fool to me as a german.
Dickkopf=bighead
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dickkopf (german for stubborn, big head) is a protein discovered in 1998 which controls head formation in embryos (PMID 9450748).
this protein is so potent that you can use it to induce a second head, overriding several ontogenetical defensive systems ("stuborn").
evolution likes to re-use components so probably has a role in hair control. f*** Androgenetic Alopecia
this protein is so potent that you can use it to induce a second head, overriding several ontogenetical defensive systems ("stuborn").
evolution likes to re-use components so probably has a role in hair control. f*** Androgenetic Alopecia
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The article if I'm reading it right is suggesting DKK2 regulates the presence of HF's in skin. TBH I'm not convinced that a therapy targeting this pathway would limit or reverse the pathogenesis of AGΑ as the HF is always present but it is just miniaturised.
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Lol always.
Great now they will fool around with this concept for the next three years then move onto something else like they did with progenator cells, then prostaglandin that promote growth then prostaglandins that inhibit growth such as pgd2. Get ready, there new discovery will be advertised to brag and nothing will happen. I'm guessing this will go on for several more years as there is so much yet to be discovered about hair obviously. Then one day they will put the puzzle together.
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I'm a pessimistic layman, but obviously researchers should be looking further into this, more understanding of hair biology can only be beneficial to the advancement of the field and bring us closer to creating a unified model for AGΑ pathology which unbelievably we do not even have yet.
I think its more accurate to say that DKK2 inhibits hair follicles in the skin. One article stated that we have hair follicles everywhere even in our hands and palms but there is a high level of Dkk2 inhibiting the growth. When the researchers removed Dkk2 hair grew in the hands and places where it doesn't grow.
It sounds like this is promising research.
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Where does it say that? Hair follicles as far as I'm aware are completely absent in our feet and in the palms of our hands, the researchers suggest DKK2 expression controls the presence of HF's in the body.
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Yes, it's been posted elsewhere on the forum. Unfortunately, the means of regulating these signaling molecules effectively is a secret the cell has not divulged and remains out of our control.
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Ba dumTss
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here's the link to the complete study.
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31763-7
"It will be exciting in the future to probe whether similar Wnt inhibitory mechanisms operate to prevent formation of fully functional skin containing hair follicles in regenerative scenarios such as healing of severe burns and to determine whether small molecule Wnt inhibitor antagonists might be used to combat such mechanisms."
https://www.cell.com/cell-reports/fulltext/S2211-1247(18)31763-7
"It will be exciting in the future to probe whether similar Wnt inhibitory mechanisms operate to prevent formation of fully functional skin containing hair follicles in regenerative scenarios such as healing of severe burns and to determine whether small molecule Wnt inhibitor antagonists might be used to combat such mechanisms."
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but they found a way to decrease risk of cancer which is new