Update Giving What Jak Pathway Needs To Be Inhibited

[dietcoke1987]

https://www.cell.com/cell-stem-cell...m/retrieve/pii/S1934590919300116?showall=true

I thought this may be important and haven't seen this new study brought up. From my understanding on the subject there are around 5 or so Jak pathways and this new study shows STAT5 is what we specifically want to inhibit in regards to restoring hair. So the others we can ignore? If so this would help us know what we specifically need to target now for more effective results.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316753/

"Another tyrosine kinase inhibitor already in clinical use in the treatment of Bcr-Abl positive leukemia, imatinib, has been shown to have an inhibitory effect on the expression of the anti-apoptotic gene, Bcl-xL, which is a target gene of STAT5 (Horita et al. 2000)."

So imatinib be worth looking into? It is under 500 daltons which makes it likely easily absorbed topically. It is soluble in water, which makes forming a topical very easy, just dissolve in water, wait for binder/filler from tablet to settle and decant off the liquid. Maybe add some leucidal as a preservative, can get it very cheap from lotioncrafter. Imatinib one can order from alldaychemist. Maybe I'm wrong about something but thought this was worth bringing up for discussion.

 

[ahmad029]

It is around Like 433 USD for
60 pills of 100 mg each from Novartis here in Asia.
You need 9 mg every day if you want to replicate aclaris's trail dosage of 0.45%
This will last you 1.83 years.
That is around 0.65 dollar per day.
Not very cheap. I guess most people would like to do that. One should look into side effects first.

 

[dietcoke1987]

It is around Like 433 USD for
60 pills of 100 mg each from Novartis here in Asia.
You need 9 mg every day if you want to replicate aclaris's trail dosage of 0.45%
This will last you 1.83 years.
That is around 0.65 dollar per day.
Not very cheap. I guess most people would like to do that. One should look into side effects first.

It is around 15 USD for 28 pills of 100mg on alldaychemist. They ship international. That was also just a suggestion of one possible option. I was hoping there would be discussion of other substances now that we know specifically what to target.

 

[ahmad029]

It is around 15 USD for 28 pills of 100mg on alldaychemist. They ship international. That was also just a suggestion of one possible option. I was hoping there would be discussion of other substances now that we know specifically what to target.

Have you considered the side effects, it's a huge list and some are severe.

 

[ahmad029]

It is around 15 USD for 28 pills of 100mg on alldaychemist. They ship international. That was also just a suggestion of one possible option. I was hoping there would be discussion of other substances now that we know specifically what to target.

Pemozide is also a stat5 inhibitor

 

[dietcoke1987]

Have you considered the side effects, it's a huge list and some are severe.

No I haven't, just trying to get the discussion going so people can brainstorm.

 

[ahmad029]

Sulphoraphan also inhibitor stat5.
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099391
Also there is a guy, who cured his alopecia areata through ginger, there are studies about ginger being a jak-stat inhibitor.
This guy has a blog.

 

[HairlossCurse]

https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30011-6?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S1934590919300116?showall=true

I thought this may be important and haven't seen this new study brought up. From my understanding on the subject there are around 5 or so Jak pathways and this new study shows STAT5 is what we specifically want to inhibit in regards to restoring hair. So the others we can ignore? If so this would help us know what we specifically need to target now for more effective results.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316753/

"Another tyrosine kinase inhibitor already in clinical use in the treatment of Bcr-Abl positive leukemia, imatinib, has been shown to have an inhibitory effect on the expression of the anti-apoptotic gene, Bcl-xL, which is a target gene of STAT5 (Horita et al. 2000)."

So imatinib be worth looking into? It is under 500 daltons which makes it likely easily absorbed topically. It is soluble in water, which makes forming a topical very easy, just dissolve in water, wait for binder/filler from tablet to settle and decant off the liquid. Maybe add some leucidal as a preservative, can get it very cheap from lotioncrafter. Imatinib one can order from alldaychemist. Maybe I'm wrong about something but thought this was worth bringing up for discussion.

are you sure it is that easy to make topical? It has to reach all the way to hair follicle and stay there, I remember Christiano talking about it.

Might be better off with injection

 

[hailbrotzu]

Would be interested in trying this. Does anyone know anything about Aclaris topical and what vehicle they might be using?