Using Ginkgo Biloba As A Crth2 Inhibitor

Folliman

Folliman

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I've been researching Ginkgo and St. John's Wort as sources for Amentoflavone since it inhibits CRTH2.

The main difference is that St. John's wort is a CYP3A4 inducer and Ginkgo an inhibitor

CYP3A4 is the enzyme responsible for metabolizing finasteride and dutasteride. High CYP3A4 means that if you're taking finasteride or dutasteride, the effect of the drugs will be shorter. Lower CYP3A4 means that the effect of the drugs will last longer, but there might be a greater chance for side effects (or overdose, according to what I've read so let's be careful.)

Sources:

http://www.pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687

https://en.wikipedia.org/wiki/CYP3A4#CYP3A4_ligands

http://www.ncbi.nlm.nih.gov/pubmed/10824623

http://www.ncbi.nlm.nih.gov/pubmed/15992226

I don't understand the following too much so correct me if I'm wrong, but in addition to that, Ginkgo seems to inhibit cAMP (at least in rats), which prematurely stops anagen.

http://www.regrowth.com/hair-loss-a...h-and-loss-of-hair/regulation-of-hair-growth/

http://www.ncbi.nlm.nih.gov/pubmed/9834158

So with Ginkgo we're attacking hair loss in 3 angles.
  1. Inhibiting CRTH2
  2. Inhibiting CYP34A to boost finasteride/dutasteride
  3. Reducing cAMP
>>Problem<<

Amentoflavone seems to reduce PGE2 levels too.

http://www.ncbi.nlm.nih.gov/pubmed/23970815

http://lib.dr.iastate.edu/cgi/viewcontent.cgi?article=1020&context=fshn_ag_pubs Page 7

These studies say it downregulates COX in combination with quercetin. (Could it just be quercetin?)

http://www.funakoshi.co.jp/data/datasheet/CHF/CFN99526.pdf

http://www.ncbi.nlm.nih.gov/pubmed/12144868

Thoughts? :/
 
WangMQ

WangMQ

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A long list of natural supplements including quercetin, resveratrol, curcumin, grape seed extract, and green tea seem to have negative effects on PGE2 by inhibiting COX altogether. But I doubt if their effect are so strong to make a difference to start with.

Curiously, ginkgo is actually mentioned by a lot of finasteride users as useful in fighting finasteride's mental side effects related to GABA.
 
E

edst

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WangMQ said:
A long list of natural supplements including quercetin, resveratrol, curcumin, grape seed extract, and green tea seem to have negative effects on PGE2 by inhibiting COX altogether. But I doubt if their effect are so strong to make a difference to start with.

Curiously, ginkgo is actually mentioned by a lot of finasteride users as useful in fighting finasteride's mental side effects related to GABA.
Click to expand...

That's interesting. I have been using finasteride 8 years ago for 12 months and using a high dose of gingko infusion at the same time.

For something like 7 months I didn't have any side effects, and now I can remember I started to have side effects once I dropped my daily gingko consumption.

Then I stopped the drugs and got stuck in PFS for like 2 years. I recovered around 80%.

I'm thinking now that maybe the consumption of gingko prevent me from having sides. But if it do why I didn't fully recover from PFS with it?
 
Xander94

Xander94

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anything that improve blood flow regrow hair.

Hairloss is def a circulation issue due to scalp tension dht/ fibrosis and idontfucking know what else
 
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