jimmystanley said:
i don't use nizoral and i already am using h&s. my question was about the ""other"" shampoos.
Nizoral
http://www.ncbi.nlm.nih.gov/entrez/quer ... s=14729013
It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of Androgenetic Alopecia is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.
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March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (male pattern baldness). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.
The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.
So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.
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Quote from Dr Lee website: Ketoconazole has been proven to decrease the quantities of DHT in the scalp by helping to inhibit its synthesis from sterols. Salicylic acid has a keratolytic and a slight antiseptic action when applied topically to the skin. By removing some of the dead epidermal layers of the stratum corneum, there is an enhanced action by the ketoconazole in suppressing the production of DHT in the scalp.
and aslo.....
quote from Nutrogenas own website: Ketoconazole has rapidly become the treatment of choice for scalp conditions such as Dandruff and Seborrheic Dermatitis , among many Dermatologists and other medical professionals. However, while patients with Hyperkeratotic scalp conditions are often encouraged to wash their hair daily, Ketaconzole is indicated for use only twice a week.
T/Sal Maximum Strength Shampoo contains 3% Salicylic Acid, primes the scalp for effective keratolitic therapy. As a first line treatment it reduces crusty scalp build – up with maximum Keratolitic Activity. So it is an ideal pretreatment for Ketoconazole and Co - therapy (Alternative days) with Tar Shampoos. Because it is fragrance free, colorant free and preservatives –free Shampoo, patients with sensitive scalps can drive the therapeutic benefits of Salicylic Acid without risk of irritation due to undesirable additives.
T/Sal Maximum Strength Shampoo is cosmetically elegant, with the conditioning shampoo base, which overcome the dryness and irritation that could accompany higher concentrations of Salicylic Acid. The result is effective therapy without having to sacrifice soft, manageable hair.
How to Use:ÂÂ
Massage into wet scalp, leave on several minutes, rinse thoroughly and repeat.
