What do people mean when they say "Propecia stops worki

[LulzKiller]

after several years?

Does it mean that it stops inhibiting DHT or that even with its DHT inhibition male pattern baldness continues to progress? Also, what's the average time that Propecia "stops working" after, 7 years, 10 years?

 

[Wash n' Gone]

It doesn't inhibit DHT completely and there are most like other factors in the pathogenesis of the condition that are still not well understood. If you extrapolate the graph out from the 5 year study then an average responder to Finasteride can expect to stay above baseline for about 10 years and then have slower hairloss than if you have never taken it. The androgen sensitivity is probably just too great in the very long run. 10 years aint too shabby though

 

[hair today gone tomorrow]

It doesn't inhibit DHT completely and there are most like other factors in the pathogenesis of the condition that are still not well understood. If you extrapolate the graph out from the 5 year study then an average responder to Finasteride can expect to stay above baseline for about 10 years and then have slower hairloss than if you have never taken it. The androgen sensitivity is probably just too great in the very long run. 10 years aint too shabby though

add in nizoral, nano, minoxidil, etc. and it COULD be even longer.

 

[Bryan]

Re: What do people mean when they say "Propecia stops w

after several years?

Does it mean that it stops inhibiting DHT or that even with its DHT inhibition male pattern baldness continues to progress?

That's an excellent question! Nobody really knows what's in the mind of an individual person who posts on one of these forums about when finasteride "stops working", because people never bother to specify exactly what they mean. My guess is that most people are aware that finasteride continues to inhibit 5a-reductase indefinitely, but sometimes male pattern baldness continues to worsen in spite of that.

Also, what's the average time that Propecia "stops working" after, 7 years, 10 years?

Now YOU are the one who isn't bothering to specify what he means! By "stop working", do you mean the point at which your haircount reaches its original starting baseline after being on finasteride for a few years, or do you mean the point at which your increased haircount starts to decline again after having it improve after you've started taking finasteride, or do you mean something else entirely?

 

[Guest]

Re: What do people mean when they say "Propecia stops w

My guess is that most people are aware that finasteride continues to inhibit 5a-reductase indefinitely, but sometimes male pattern baldness continues to worsen in spite of that.

Probably because 85% 5ar2 reduction isn't enough, right?

Now YOU are the one who isn't bothering to specify what he means! By "stop working", do you mean the point at which your haircount reaches its original starting baseline after being on finasteride for a few years, or do you mean the point at which your increased haircount starts to decline again after having it improve after you've started taking finasteride, or do you mean something else entirely?

Well I'm not sure what he means either but if he means declining again, that happened in year 2 of the Merck Propecia chart, but extrapolating the chart out, it looks like the average person hits baseline again after 12-14 years on finasteride.

 

[Bryan]

Re: What do people mean when they say "Propecia stops w

My guess is that most people are aware that finasteride continues to inhibit 5a-reductase indefinitely, but sometimes male pattern baldness continues to worsen in spite of that.

Probably because 85% 5ar2 reduction isn't enough, right?

Seems like a reasonable supposition.

Well I'm not sure what he means either but if he means declining again, that happened in year 2 of the Merck Propecia chart, but extrapolating the chart out, it looks like the average person hits baseline again after 12-14 years on finasteride.

What surprises me is the number of people who seem to think that once you hit the original starting baseline again, that's it, it's the end of the finasteride story. But even after that, it's going to continue to strongly inhibit the fundamental male pattern baldness process by greatly SLOWING DOWN further balding. As I've pointed out many many times, the difference in haircounts between finasteride users and placebo users is going to continue to INCREASE even after many many years, it's not going to DECREASE.

 

[Guest]

Re: What do people mean when they say "Propecia stops w

What surprises me is the number of people who seem to think that once you hit the original starting baseline again, that's it, it's the end of the finasteride story. But even after that, it's going to continue to strongly inhibit the fundamental male pattern baldness process by greatly SLOWING DOWN further balding. As I've pointed out many many times, the difference in haircounts between finasteride users and placebo users continues to INCREASE, it doesn't DECREASE.

Bryan, another thing people neglect to mention is that even once they hit baseline, okay they're there, but it takes 50% of density lost to see balding generally. So if someone hits baseline in year 14, it will probably take them at least 4 or 5 years after that for them to actually realize VISUALLY that they are continuing to lose hair. The naked eye is pretty weak. Most people can't tell the difference visually between 80 hairs per circular inch and 100, for example.

 

[LulzKiller]

By not working I mean losing hair again, even if it's hair you regrew while on Propecia.

 

[Guest]

By not working I mean losing hair again, even if it's hair you regrew while on Propecia.

year 2 usually

 

[mschai]

i think it depends on individual.
Some took it for > 5-10 yrs and still maintaining.....

 

[Guest]

i think it depends on individual.
Some took it for > 5-10 yrs and still maintaining.....

i dont think we're talking about the same thing. if you're talking about not even losing another hair on finasteride, even any of the regrown hair, i don't think there's anyone who's been on it for 10 years who has had that happen.

 

[haunted-ballroom]

So are you guys saying that if you started finasteride while you were a nw2, that you would stay a nw2 for 10 years plus?

 

[Guest]

So are you guys saying that if you started finasteride while you were a nw2, that you would stay a nw2 for 10 years plus?

yep most likely

 

[haunted-ballroom]

So are you guys saying that if you started finasteride while you were a nw2, that you would stay a nw2 for 10 years plus?

yep most likely

Awesome :lol:

 

[lucy923]

thats good news fellas, what do you think if one added minoxidil and got pretty good regrowth and thickening and was on finas/nizoral also.....how long would that person be able to keep the new growth from the minoxidil??? Does that always stay as long as you keep up the minoxidil or does that start to fade away with time also???

And what do you think is the average time a responder of finasteride/minoxidil/nizoral can stay above baseline?? I would think it would be quite a few years more than just finasteride??

 

[RaginDemon]

f*** if i can keep my hair for another 10 yrs, I will be completely happy.

 

[lucy923]

f*** if i can keep my hair for another 10 yrs, I will be completely happy.

Right on brotha.....I'm 27 right now and if I can hold on to my hair for 10-12 years that will put me at almost 40 and will be more accepted by then and by then for sure something better will be out so there's a chance people who just started balding right now may not get any worse for the rest of their life. It really is the best time ever in the history to be balding with hm and other possible cures coming out in the near future. Just hold on for a few years boys and we'll all be laughing. It is just stressing thinking you could get aggressive balding and bald before a cure but most likely not if one gets on the big 3

 

[Nathaniel]

thats good news fellas, what do you think if one added minoxidil and got pretty good regrowth and thickening and was on finas/nizoral also.....how long would that person be able to keep the new growth from the minoxidil??? Does that always stay as long as you keep up the minoxidil or does that start to fade away with time also???

And what do you think is the average time a responder of finasteride/minoxidil/nizoral can stay above baseline?? I would think it would be quite a few years more than just finasteride??

Adding minoxidil and nizoral to finasteride would maintain your hair for a long long time and at the very least slow down male pattern baldness dramatically compared to placebo.

 

[emery]

hi guys, propecia have stopped working after 16 months mark.. and i hve to quit for suddendly increase in side-effect... thanks god... my dick is back 80% after quitting for 2 weeks... hopefully i can regain to 100% soon.. this sh*t is scary yo.

bu thonestly, at 12 months mark... the hair desnity was like 2 yrs younger.