collegechemistrystudent said:
It does not matter, as long as you remember. between meals give a bit better absorption, as does eating grapefruit, but finasteride doses don't matter much.
Eating grapefruit or drinking its juice is a bad idea generally with taking meds.
Even hairloss gurus suggest it is not safe...
Can grapefruit/grapefruit juice be harmful when taking Propecia?
Strangely enough, yes, it can. Drinking grapefruit juice to wash down the oral doses of finasteride can raise the blood concentrations of the drug beyond what the dosage has been known to do. Unlike other citrus juices, grapefruit juice inhibits one of the body's intestinal enzyme systems and can result in marked increases in absorption of the drugs. Within the liver, the grapefruit juice competes with finasteride in its metabolic pathways and may further increase the serum levels of many prescription drugs.
Studies show that the interaction of grapefruit juice with drugs involves the compounds in grapefruit juice, called furanocoumarins (e.g. bergamottin), which block the enzymes in the intestines that normally break down many drugs, allowing more of the drug to be absorbed into the bloodstream.
In addition, grapefruit juice is one of the foods most likely to cause problems with drugs, because it is metabolized by the same enzyme in the liver that breaks down many drugs, including finasteride. The cytochrome P-450 3A4 enzyme breaks down grapefruit juice into useful components for the body, just like it breaks down dozens of medications. But, if the grapefruit juice can overload the system, keeping the liver busy and blocking it from breaking down drugs and other substances, the blood levels of the affected medication may remain too high.
Some sources recommend not ingesting grapefruit juice within 2 hours before and 5 hours after a drug, which may interact with it. Others contend that one glass of grapefruit juice could elicit the maximum blocking effect, and that the effect may persist for longer than 24 hours. Therefore, a safer approach would be to substitute another citrus juice, such as orange juice, which has the same vitamins but has not demonstrated the drug interactions.
Richard Lee, M.D.
Regrowth, LLC,
http://www.Minoxidil.com
So it seems better to avoid the stuff if you are on meds of any kind.
Joe.
