whats going on with the JAK drugs ?

[minoxiDjunkie]

havent been around for about a year,
so i remember that back at the time people were just starting to experiment with the JAK inhibitors,
what going on with it ?
can someone point me to a thread of someone that experimented with it and documented it / or - just wrote about it ?

 

[NewUser]

havent been around for about a year,
so i remember that back at the time people were just starting to experiment with the JAK inhibitors,
what going on with it ?
can someone point me to a thread of someone that experimented with it and documented it / or - just wrote about it ?

Dr Christiano believes a high concentration of JAKinib around follicles is needed for best effect, and the team of herself, Colin Jahoda, Higgins etc used a special topical delivery formula to grow hair for AA patients. Aclaris pharmaceuticals recently bought Christiano's hair research company and IP and currently have an oral drug and topical in pre-clinical stage of development. Christiano said she welcomes the new deal and looks forward to developing treatments for AA, androgenic alopecia and other hairloss disorders.

 

[minoxiDjunkie]

Dr Christiano believes a high concentration of JAKinib around follicles is needed for best effect, and the team of herself, Colin Jahoda, Higgins etc used a special topical delivery formula to grow hair for AA patients. Aclaris pharmaceuticals recently bought Christiano's hair research company and IP and currently have an oral drug and topical in pre-clinical stage of development. Christiano said she welcomes the new deal and looks forward to developing treatments for AA, androgenic alopecia and other hairloss disorders.

yea but that was the "regular" alopecia areata study ....

im talkking about guys on here (well on hairlosshelp and btt) that have tried that experimentally for Androgenetic Alopecia
but i guess now that if there were no hype on here or at least some update than nothing happened ... unfortunatly

 

[NewUser]

yea but that was the "regular" alopecia areata study ....

im talkking about guys on here (well on hairlosshelp and btt) that have tried that experimentally for Androgenetic Alopecia
but i guess now that if there were no hype on here or at least some update than nothing happened ... unfortunatly

I don't think she just mixed Tofacitinib with some 5% rogaine solution or anything like that. In her research paper she mentions that she and her team, who until relatively recently included Claire Higgins who has left for other endeavors, and Colin Jahoda are developing a special 3d spheroid delivery formula for the drug.

Apparently Tofacitinib has a relatively short half life. I think if the bathroom sink experimenters are not getting the stuff to the follicles, then they surely will be disappointed with the results. Christiano said the drug is larger molecule and will require some expertise in creating a decent formula for delivery to follicles where it will count the most. Just sayin'?

 

[Sweuser]

Doesn't this speak against the use of jak inhibitor for Androgenetic Alopecia? Maybe it will only be effective for AA etc...

[h=1]STAT5 activation in the dermal papilla is important for hair follicle growth phase induction.[/h]
[h=3][/h]

[h=3]Abstract[/h]Hair follicles are skin appendages that undergo periods of growth (anagen), regression (catagen) and rest (telogen), regulated by their mesenchymal component, the dermal papilla (DP). Based on reports of its specific expression in the DP, we investigated STAT5 activation during hair development and cycling. STAT5 activation in the DP began in late catagen, reaching a peak in early anagen before disappearing for the rest of the cycle. This was confirmed by the expression profile of SOCS2, a STAT5 target in the DP. This pattern of expression starts after the first postnatal hair cycle. Quantification of hair cycling using the Flash canonical Wnt signalling in vivo bioluminescence reporter found that conditional knockout of STAT5A/B in the DP targeted through Cre recombinase under the control of the Sox18 promoter, resulted in delayed anagen entry compared to control. Microarray analysis of STAT5-deletion versus control revealed key changes in TNF-alpha, Wnt and FGF ligands, known for their role in inducing anagen entry. We conclude that STAT5 activation acts as a mesenchymal switch to trigger natural anagen entry in post-developmental hair follicle cycling.