Why did GSK halt Avodarts' testing on hairloss treatment?

[ecs]

Does anyone know what actually happened and why they halt the test?

 

[Bryan]

The results weren't better enough than Propecia to really stand out in the minds of consumers. Propecia has never been a big money-maker for Merck, so the Glaxo people didn't think it was worth the effort to continue hairloss as an additional indication for dutasteride.

Bryan

 

[IDOASIS]

http://www.hairlosstalk.com/newsletter/article224.htm

Glaxo merged with Burroughs-Wellcome, and was then called Glaxo-Wellcome. This merger was fine, because the clinical studies for Dutasteride had already been completed through phase II. The results analyzed by the company showed that it really was an effective agent for hair growth in men; however, the company underwent another merger with Smith-Kline, in 1999. Phase III is the final leg of the study process, and if the ball had already been rolling, the company may have proceeded to complete the approval process


However, when the new top officials took over, they concluded something unsavory about the profitability of Dutasteride. After some analysis, they decided that Dutasteride would not make profits of over 500 million per year as a hair loss treatment, so it was placed to the side for other new drug development projects

To date there are only two clinically proven products on the market. Sales of these products, Minoxidil (also known as Rogaine) and finasteride (also known as Propecia) were not making Wall Street projections, barely grossing $100 million per year

This doesn’t mean that Dutasteride wasn’t a blockbuster drug, but with the media hype about the sexual side effects of Finasteride/Propecia so inflated, it was hard to repair the damage

 

[CCS]

the only reason I don't take 0.5mg every day is the cost, not the side effects. avodart has rare, tame side effects. very few people can afford 5 a day, but I'd be a bit worried about 5 a day because it inhibits most 5ar1, which is in the brain.

 

[Guest]

the only reason I don't take 0.5mg every day is the cost, not the side effects. avodart has rare, tame side effects. very few people can afford 5 a day, but I'd be a bit worried about 5 a day because it inhibits most 5ar1, which is in the brain.

by affording 5 a day i assume you mean 0.5 milligrams and not 5? I'm not sure so I'm assuming. But a year's supply of 0.5 mg avodart can be found all over the web for around $350.

 

[Slartibartfast]

Only if you're buying generics, a year's worth of Glaxo. Avodart will be at least double that - though I think he meant taking 5 a day is unaffordable for most rather than the typical .5mg dose.

 

[RSG]

Just a question...does propeica have any effect on the brain? Like does it somehow indirectly muck around with the type I enzyme?

Cheers

 

[Guest]

Only if you're buying generics, a year's worth of Glaxo. Avodart will be at least double that - though I think he meant taking 5 a day is unaffordable for most rather than the typical .5mg dose.

true but what's wrong with genetics?

and oh i misunderstood

 

[IDOASIS]

Only if you're buying generics, a year's worth of Glaxo. Avodart will be at least double that - though I think he meant taking 5 a day is unaffordable for most rather than the typical .5mg dose.

Not accurate.
In my country a prescribed Glaxo Avodart costs 30$ ,even
cheaper than generics

 

[bubka]

the magic number for a drug was 1billion a year... probably more now... if it can't reach that, usually it will not be further developed

IDOASIS: where are you getting real Avodart for $30... is that after insurance... which most will not cover for MBP, let alone off labeling it

 

[IDOASIS]

IDOASIS: where are you getting real Avodart for $30... is that after insurance... which most will not cover for MBP, let alone off labeling it

Yep.
My doctor doesnt need to know that it is for male pattern baldness.

 

[bubka]

i don't understand, he just wrote you an rx without a symptom to treat...?

many will not right Proscar scripts for MBP if you have insurance because it can technically be insurance fraud as the doctor is knowingly off labeling a drug knowing insurance will pay for it...

Again, so does your insurance pay for your Avodart and $30 is the copayment then?

 

[IDOASIS]

Again, so does your insurance pay for your Avodart and $30 is the copayment then?

YES ,IT IS AFTER INSURANCE.

I took some Dutas with me ,and told her I use it for BPH.
I said to her that it has come into my knowledge the insurance
covers half of the costs .
She agreed to give me a prescription.

 

[bubka]

ok, well good deal then, but still, dutrastride is not cheaper then finasteride

 

[IDOASIS]

ok, well good deal then, but still, dutrastride is not cheaper then finasteride

It depends ,on what are u talking about ,proscar or propecia
(and I am not talking about generics).

 

[CCS]

one avodart capsule every 5 days has the same strength as 5mg finasteride every day. That is 1/5 the price. I think dutasteride is very weak at very low concentrations, though I might have misinterpretted what I saw.

Finasteride looses 20% of its hair growing power every time you cut the dose by a factor of 5, but might not be affective at all below 0.05mg/day.

 

[IDOASIS]

Finasteride looses 20% of its hair growing power every time you cut the dose by a factor of 5.

Why?
Please explain yourself.
Do u mean 1 Vs 5 mg?

 

[CCS]

this is based on reading that 0.2mg/day finasteride grows 82% as much hair as 1mg/day, which grows 83% as much as 5mg/day. I don't remember where I read it, but it looked reliable at the time.

From a different source,
0.01mg/day reduces DHT only 5%, whereas 0.05 reduces it almost as much as 5mg, though I suspect the 0.05mg measurement was a fluke because on the graph 1mg inhibited less than 5mg, but 0.05 inhibited more than 1mg.

 

[IDOASIS]

this is based on reading that 0.2mg/day finasteride grows 82% as much hair as 1mg/day, which grows 83% as much as 5mg/day. I don't remember where I read it, but it looked reliable at the time.

Not exactly.
Finasteride haircount After 6 months:
0.2 mg +61
1 mg +77


After 1 year , 5 mg +95 .

http://www.hairlosstalk.com/download/finmicro.pdf

By Dutasteride study ,5 mg Finasteride after six month , +72.

http://www.dutasteride.org/dutasteride/ ... esults.htm

I agree that there is a different between 0.2 and 1 mg ,
but there is no significant difference between 1 and 5 mg

 

[Slartibartfast]

Only if you're buying generics, a year's worth of Glaxo. Avodart will be at least double that - though I think he meant taking 5 a day is unaffordable for most rather than the typical .5mg dose.

Not accurate.
In my country a prescribed Glaxo Avodart costs 30$ ,even
cheaper than generics

My response was to JayMan's remark that: "...a year's supply of 0.5 mg avodart can be found all over the web for around $350." I don't see how it being available on prescription in your homeland for only $30 (per month, I assume) would constitute that.

Slarti