Why haven’t one of you High-Functioning autists solved hair loss?

[Lokus423]

High-Functioning autists put man on the moon, created airplanes and solved some of the most difficult questions and problems of life through an extremely religious dedication for many decades. I’m fascinated to read about 19 century scientists and the excruciating pain they put themselves through trial and error, some even putting their own lives on the line to further scientific knowledge.

Yet, something that threatens the very reproductive success of our genes, like balding, is still not solved? I understand that a cure in itself may be hard to produce but at least we should have a coherent theory that is without contradictions which can explain the nature of MPHL? I mean, you don’t even need any resources in this day and age; the internet provides with all the scientific journals you would ever need yet we can’t put together one coherent theory that isn’t full of holes?

 

[Armando Jose]

yes, a coherent theory is needed.

 

[Regan]

The high functioning autists are congregating in various incel discord channels testing their theories by trying out various chinese basement chemicals.

(*which are applied exclusively to their research subject.)

 

[Capone]

Even the richest man in the world got a transplant

 

[Lokus423]

The high functioning autists are congregating in various incel discord channels testing their theories by trying out various chinese basement chemicals

Good, this is exactly what we need. The more autistic, intelligent and daring, the better.

 

[Lokus423]

Even the richest man in the world got a transplant

Because it worked for him and he has other things to worry about now that hair loss is no problem to him. Yet, he could fund the cure and solve it in no time.

 

[Mr. Slap Head]

you are mistaken, they are low functioning

 

[Te1963]

I don't think that you understand how this works. Almost all of the top medical researchers are searching for pharmaceutical applications which can be used, long term, to ameliorate hair loss. Curing it will not enrich the pharmaceutical companies.

They now know the basic pathways involved in generation of hair loss. While a variety of things can trigger the process it often involves allergy. Allergic involvement in calcification of osteoblast cells via prostaglandin D2. Mast cell signaling to activate proliferation of osteoblast cells using dihydrotestosterone. Sphingosine-1-phosphate inhibition of that proliferation to prevent cancer. Sphingosine-1-phosphate inhibition of keratinocytes involved in hair production.

If you catch the allergy early enough then eliminating exposures should, theoretically, reverse the hair loss. Catch it too late and the process is complicated by immune dysregulation. At that point you wind up with a range of individual-specific genetic factors which are going to get in your way. Complicate that with the fact that most people just want a button which they can push which will fix everything, rather than complex allergy identification testing, and pharmaceutical companies are guaranteed to become rich.

 

[mminh]

I don't think that you understand how this works. Almost all of the top medical researchers are searching for pharmaceutical applications which can be used, long term, to ameliorate hair loss. Curing it will not enrich the pharmaceutical companies.

They now know the basic pathways involved in generation of hair loss. While a variety of things can trigger the process it often involves allergy. Allergic involvement in calcification of osteoblast cells via prostaglandin D2. Mast cell signaling to activate proliferation of osteoblast cells using dihydrotestosterone. Sphingosine-1-phosphate inhibition of that proliferation to prevent cancer. Sphingosine-1-phosphate inhibition of keratinocytes involved in hair production.

If you catch the allergy early enough then eliminating exposures should, theoretically, reverse the hair loss. Catch it too late and the process is complicated by immune dysregulation. At that point you wind up with a range of individual-specific genetic factors which are going to get in your way. Complicate that with the fact that most people just want a button which they can push which will fix everything, rather than complex allergy identification testing, and pharmaceutical companies are guaranteed to become rich.

Interesting. Can you share more about what led you to that hypothesis, pls?

 

[Te1963]

After collapsing at work some years ago doctors denied that my resulting ill health had any relation to my employment, leading me to being forced to prove that it was. I have had to do a ton of investigations into how silica nanoparticle sprays induced my condition. Along the way I learnt a lot about my other health issues. I already knew that I lost my hair, in my late teens, because of gluten allergy so that made my initial point of investigation pretty easy.

While I tried to include links to medical research I am still a new member and the links are not permitted. I will have to stick to just the explanation.

Inhibition of prostaglandin D2 is already being used and investigated for restoration of hair.
Prostaglandin D2 induces calcification/apotosis (cell death) of osteoblast cells.
Dihydrotestosterone induces proliferation of osteoblast cells.
Sphingosine-1-phosphate mediates dihydrotestosterone induced cell proliferation.
Sphingosine kinase, which converts sphingosine to sphingosine-1-phosphate, is expressed by cancer cells, theoretically inducing apoptosis (cell death).
However, sphingosine-1-phosphate can also be produced to try to keep the osteoblast cells alive, rather than inhibit proliferation and cancer.

I am fairly certain that the high sphingosine levels, over time, result in atopic dermatitis.
The consequence of which is that the body overexpresses ceramide synthase 4 in order to try to keep control of the dermatitis.
Many of us will associate dandruff with our hair loss but atopic dermatitis can be mistaken for dandruff.

Ceramide synthase 4 is also essential to hair follicle cycling.
Without this compound alopecia areata results.
At this point I am left to pure speculation that overexpression of ceramide synthase 4, over a long period of time, will eventually lead to reduced production and release of it, so leading to alopecia.

 

[mald]

There are already totally effective treatments like Elon Musk got. You just need to be rich and get a good transplant.

 

[Te1963]

Yes, but you always have to ask yourself about the potential side effects of these treatments. Assume, for a moment, that I am correct about the risks of either experiencing a massive die-off of osteoblast cells, resulting in severe osteoporosis and joint issues, or of the development of extremely aggressive cancer if you get your treatment wrong. You have to wonder whether the cure for the hair loss is worth that price. Maybe it's the fact that I have lived with being bald for so long, or maybe it's my Buddhist perspectives which make me reasonably unconcerned, but I don't believe in having hair at any price. I took a look at the side effects of one of the prostaglandin D2 inhibitors and was horrified. Try taking a look at the list of potential side effects of finasteride some time. I signed up with this forum because I was reading posts by people who seemed to already understand the connections I have already detailed but who have chosen to use these medications anyway, comparing the results with each other.

 

[mminh]

Yes, but you always have to ask yourself about the potential side effects of these treatments. Assume, for a moment, that I am correct about the risks of either experiencing a massive die-off of osteoblast cells, resulting in severe osteoporosis and joint issues, or of the development of extremely aggressive cancer if you get your treatment wrong. You have to wonder whether the cure for the hair loss is worth that price. Maybe it's the fact that I have lived with being bald for so long, or maybe it's my Buddhist perspectives which make me reasonably unconcerned, but I don't believe in having hair at any price. I took a look at the side effects of one of the prostaglandin D2 inhibitors and was horrified. Try taking a look at the list of potential side effects of finasteride some time. I signed up with this forum because I was reading posts by people who seemed to already understand the connections I have already detailed but who have chosen to use these medications anyway, comparing the results with each other.

Thank you for sharing your experience .

I think you have the right approach. I see people dealing with balding as: "Oh, in this disease, the A, B, or C is rising, so let's find a way to reduce, inhibit it". I don't believe this approach leads to a satisfying result, you block the human body's mechanism, the human body will find a way to fight back.

In your case, my guess is you are still balding even if you remove gluten in your diet, but the bald rate is slowing down? Imo there are more things related to this disease, allergy is one of those but there are more.

 

[Te1963]

After giving up gluten from my diet my health boomed. I experienced increased energy, cessation of migraines, greater physical strength, and a host of other benefits. There was only a mild effect upon my hair but I have been bald for more than thirty years now so didn't really expect any miracles. To be honest, I actually got more hair growth from putting on sun tan lotion, back when I was fit an healthy and going swimming and sunbaking. I wound up finding out that the lactones in the lotion, even though mildly toxic, have the mild effect of stimulating hair gain, lol.

Due to the fact that I still have to engage in legal action, to prove the damage caused by my work exposures, I have been strongly advised to do absolutely nothing which might reverse my ill health and disability. As most of the actions required to stimulate hair regrowth, via mast cell mediation, would have at least some effect upon my condition I can't even begin to try anything. A lot of good lists of the type of things that I plan, however, can be found if you do an online search for 'mast cell diet'. Although I have eliminated the gluten it is highly likely that even things like nightshade fruits and vegetables and other foods containing toxins are likely to be continuing to trigger the prostaglandin D2 production and resulting hair loss. In theory, the hair follicles themselves should be able to regenerate and commence hair growth again once that stimulation ceases. In my view that beats having all of the side effects of a bunch of medications.

 

[mminh]

Due to the fact that I still have to engage in legal action, to prove the damage caused by my work exposures, I have been strongly advised to do absolutely nothing which might reverse my ill health and disability. As most of the actions required to stimulate hair regrowth, via mast cell mediation, would have at least some effect upon my condition I can't even begin to try anything. A lot of good lists of the type of things that I plan, however, can be found if you do an online search for 'mast cell diet'. Although I have eliminated the gluten it is highly likely that even things like nightshade fruits and vegetables and other foods containing toxins are likely to be continuing to trigger the prostaglandin D2 production and resulting hair loss. In theory, the hair follicles themselves should be able to regenerate and commence hair growth again once that stimulation ceases. In my view that beats having all of the side effects of a bunch of medications.

Hope things go well for you bro.

 

[Te1963]

Same to you.

 

[mald]

The solution is to stop malding

 

[Te1963]

At the moment my best bet is on Sonic the hedgehog. No, not joking. Some fellow 'nerds', working in laboratories, named communication between localised cells after the computer game. While the principle applies to a lot of diseases, throughout the body, it also applies to hair loss.

Prostaglandin D2, mentioned previously as inducing calcification of osteoblasts, also affects fibroblasts in the skin; inducing atopic dermatitis. Sonic hedgehog protein communication seems to inhibit the development of this dermatitis and restore hair. A number of methods for reactivating this communication are under development or awaiting patent approval. A search on this site provides details of some investigations.

 

[Te1963]

There has been a little discussion regarding the potential of resveratrol as a hair regain substance. While I have looked at the supplement for a number of other health issues I have never looked at its potential for hair. Part of the issue with hair loss involves dihydrotestosterone induced increase in interleukin-6 expression, which inhibits hair length. Resveratrol can downregulate interleukin-6 expression and can also activate sonic hedgehog pathway expression. Although this has tested, in animals, to be effective in restoring hair growth it has not been tested in humans. Resveratrol also appears to have been tested to have beneficial effects upon osteoblast cells, likely reducing the inflammatory processes prior to hair loss. Whether topical or oral intake is better seems to be anyone's guess.

 

[Feramon1]

Because it's a paradox. To solve the paradox, it is necessary not to look for an answer, but to ask the right question, from the right angle, no one has asked it yet.