Pleasantly Suprised With Topical Ramatroban So Far

[Chimac07]

Curiously, since rama and seti are both crth2 antagonists and we know as a matter of fact messing with pgd2 influence your sleep, how could you get sleep sides from seti and not from rama?

Beats me. For what its worth, Im taking rama topically. Maybe less effects systemically, after all, the inflammation I am trying to stop is in my scalp. Oral seti would inhibit PGD2 everywhere else, which may be the reason for sleep issues etc.

My sleep is easily effected by whatever I take or do. Rama has had no effect in my short experience so far.

 

[Chimac07]

Thanks for the update. If it's not too late. I'd really like to try Seti if you have any left.

PM me your address. No one has asked yet. So youre the first. Ill send you 15G, enough to try it for 2 weeks at high dose like they say you should.

 

[mowingdown]

lol....ummm ok?

please explain HOW that is possible

CYP3A4 mutations. Happened to me as well. It's a serious issue because I can't take most pharmaceuticals without severe side effects. Basically, the liver does either a sh*t job, expected job (pharma targeted dosage), or extremely efficient job (drugs lose efficacy) at metabolizing drugs. Worked like a charm for a week or so before I saw some really concerning sides, specifically word slurring was the scariest of the bunch. This is just one piece of the puzzle for finasteride sides as I could theoretically try and mitigate these issues with an inducing substance (like St. Johns Wort), but that still doesn't fully solve my issues with it.

 

[SamFT]

PM me your address. No one has asked yet. So youre the first. Ill send you 15G, enough to try it for 2 weeks at high dose like they say you should.

I'd like to try some too as well

 

[mowingdown]

PM me your address. No one has asked yet. So youre the first. Ill send you 15G, enough to try it for 2 weeks at high dose like they say you should.

On the second thought I think I'm alright with trying it. I appreciate what you're doing though. Could you describe your hair type/length? You said your maintaining, so you still have a full head of hair? Are you applying it all over your scalp? I'm receding/diffusing at a slow rate with hair about 4-5 inches in length so I'm also looking for something for maintenance.

 

[Chimac07]

On the second thought I think I'm alright with trying it. I appreciate what you're doing though. Could you describe your hair type/length? You said your maintaining, so you still have a full head of hair? Are you applying it all over your scalp? I'm receding/diffusing at a slow rate with hair about 4-5 inches in length so I'm also looking for something for maintenance.

My pleasure bud. Here's my pic taken a little over a year ago. And here is a pic of my hair i literally just snapped. I am a diffuse thinner. You can see how my density on the top scalp has severely diminished in the last year. What most people say they regretted most, was that they started combating their hair loss late in the game. I wasn't going to make that mistake. Unfortunately though, nothing has worked. I am not even saying rama is for sure curing me, as its only done so for 7 days thus far. I am applying it twice a day on the entire thinning top.

 

[mowingdown]

My pleasure bud. Here's my pic taken a little over a year ago. And here is a pic of my hair i literally just snapped. I am a diffuse thinner. You can see how my density on the top scalp has severely diminished in the last year. What most people say they regretted most, was that they started combating their hair loss late in the game. I wasn't going to make that mistake. Unfortunately though, nothing has worked. I am not even saying rama is for sure curing me, as its only done so for 7 days thus far. I am applying it twice a day on the entire thinning top.

Thanks a bunch for the photos. One last question: did you notice the same kind of hairloss stoppage with finasteride, as in you took it and immediately noticed within a very short period of time hair shedding subsided or reduced? Sounds like we have extremely similar situations.

 

[spring15]

Hope you find success with this. Still early days however

 

[Chimac07]

Thanks a bunch for the photos. One last question: did you notice the same kind of hairloss stoppage with finasteride, as in you took it and immediately noticed within a very short period of time hair shedding subsided or reduced? Sounds like we have extremely similar situations.

No, finasteride never did anything. Hair loss has always remained constant. I was on finasteride for 1.5 years, hoping it would finally kick in. I got gyno, killed my dick when on it, brain fog, lower energy, and memory issues. I am not a responder to finasteride even in the slightest. I dont believe DHT to be the cause of my hair loss. Everything recovered when i got off, except the two lumps in each nipple. I been meaning to get it cut out, just avoiding because my fear of going under the knife.

I side with the belief male pattern baldness is an autoimmune disease. I believe im allergic to something that I am not changing, which is causing constant inflammation, leading to follicle weakening.e.

 

[ALightInTheDark]

Cotsarelis' theory also applies to seti.

I know this is what I'm saying and in majority of my posts.

What are you talking about? You clearly have no clue. Cots theory IS seti. As far as potency, its TM>Rama>Seti

Seriously, optimized vs oral seti? I know what youre referring to, but you didnt even say it right. You drunk dude?

Ramatroban is a TX antagonist which also is DP2 antagonist.
Seti acts as a DP2/CRTH2 antagonist
Not exactly the same.

And I know Cots theory is PGD2 blabla I told this everytime.
When I say weaker,I mean less useful, TM has a ridculosly long life and Ramatroban may reduce PGF2a and PGE2 if I remember well.
So not what we want if you want regrowth.

Ahah no I was just really tired,but if you understand what's my point, it's all good !

http://www.hairsite.com/hair-loss/board_entry-id-119020-page-0-order-time-category-0.html

People tested it long time ago.
Hope you've got good results OP!

 

[champpy]

@Chimac07
Iron dragon used to sell a product known as indomethacin. It also slowed my loss DRAMATICALLY in like 2 days. I remember feeling like i had this thing beaten, it was amazing. Then after a week i got horrible scalp irritation. Like insanely bad. I had to stop due to the rash. Since then they stopped selling it
Anyway, my point is yes, i agree it is possible to almost halt shedding incredibly fast if you have something that actually works

 

[Chimac07]

@ALightInTheDark from my research, ram does not interfere with PGE2. I dont know about PGF2a. I could be wrong, but pretty confident.

@champpy that sucks man. I honestly being wishing for this excitement for the longest. I didnt expect this to do anything at all honestly. I stumbled across this stuff while actually searching for natural pgd2 inhibitors(dont know how this popped up from that lol). Ill update you guys in a week.

 

[champpy]

Yes please keep us posted. I havenf bought anything from iron dragon in years but if this keeps working for you i might give it a try too

 

[ALightInTheDark]

Indo,Cromo and Rama can halt hair loss for real like in this thread I posted
But I have some doubts about it like bad experiences from various users.

 

[champpy]

Cutting edge: agonistic effect of indomethacin on a prostaglandin D2 receptor, CRTH2.
Hirai H1, Tanaka K, Takano S, Ichimasa M, Nakamura M, Nagata K.
Author information

Abstract
Indomethacin is a widely used nonsteroidal anti-inflammatory drug and is generally known to exhibit its multiple biological functions by inhibiting cyclooxygenases or activating peroxisome proliferator-activated receptors. In this study, we present evidence demonstrating that the novel PGD(2) receptor chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is another functional target for indomethacin. Indomethacin induced Ca(2+) mobilization in CRTH2-transfected K562 cells at submicromolar concentrations (approximate EC(50), 50 nM) in a G(alphai)-dependent manner as PGD(2) did. Other nonsteroidal anti-inflammatory drugs (aspirin, sulindac, diclofenac, and acemetacin) had no such effect even at micromolar concentrations. In chemotaxis assay, three CRTH2-expressing cell types, Th2 cells, eosinophils, and basophils, were all significantly attracted by indomethacin (EC(50), 50-500 nM) as well as by PGD(2) (EC(50), 2-20 nM), and the effects of indomethacin were blocked by anti-CRTH2 mAb. These results suggest the involvement of CRTH2 in mediating some of therapeutic and/or unwanted side effects of indomethacin, independently of cyclooxygenases and peroxisome proliferator-activated receptors.


= Indomethacin ups CRTH2, despite inhibiting COX-2(and hence, PGD2). This means Indomethacin itself is a substrate(aka substitute in place of PGD2) for CRTH2-binding.


They stopped selling it not because the stuff was fake, but because it causes hairloss via the same mechanism as PGD2(people thought COX-2 inhibitors were good for hair because they inhibit PGD2)

Im not going to lie and say that i understood that completely, lol, but i think your saying that it stopped hair loss but also stopped hair growth???
I believe i experienced this. I didnt see any hair loss (minimal) but my hair still seemed to get wispy and thinner while on the stuff too

 

[Chimac07]

Lurking through their other products, I see astragaloside IV and Cycloastragenol for sale. No idea what this stuff is really but a quick glance, it drastically increases T cells. Me likey so Im probably going to try astragaloside IV and see whats up.

 

[champpy]

Nope.

Im saying Indomethacin causes hair loss just like PGD2. Your scalp is going to be even more oilier from it. I can post more studies on this, but im tired of doing it in public forums.

Use Rama twice/day. It's half life is ~7hrs. You need to reapply by the 14th hr,max- from your previous application. Ideally, use it every 7hrs.

Keep using it- it targets multiple pathways of Androgenetic Alopecia.

Thanks man. So I'm guessing you've been using Rama and have noticed it helps you as well? You never got any scalp irritation from it?

 

[spring15]

How's it going @Chimac07 ?

 

[Trax1]

Use Rama twice/day. It's half life is ~7hrs. You need to reapply by the 14th hr,max- from your previous application. Ideally, use it every 7hrs.

Hi man, seems like you familiar with ramatroban, maybe you could advice - what is the effective dosage (mg/ml) ? And where i can buy the powder ?
Thank you in advance.

 

[BaldyBalderBald]

Cots and the Follica team are not using Seti/Fevi for their trials tho.IIRC they are developing their own Chrt2 antagonists