Mast Cell Product Histamine Raise Dht

[arnoldd]

Hey guys what do you think about this study?

In allergies histamine is release in large quantities after mast cell desgranulation

https://www.ncbi.nlm.nih.gov/m/pubmed/11420057/

 

[Sworthyy]

Could you clarify what this study might indicate????

 

[arnoldd]

When you have an allergy or an autoimmune disease your body release histamine.

This study indicate that histamine increase dht levels..so maybe allergies or others immune problems can speed hair loss in people prone to male pattern baldness

 

[Sworthyy]

Ahhh

Interesting as i suffer really bad from allergies, there was thread on here about a week ago saying that histamine tabalets can actually help hair loss

 

[Afro_Vacancy]

Ahhh

Interesting as i suffer really bad from allergies, there was thread on here about a week ago saying that histamine tabalets can actually help hair loss

?

 

[Sworthyy]

What ??

 

[Afro_Vacancy]

Hey guys what do you think about this study?

In allergies histamine is release in large quantities after mast cell desgranulation

https://www.ncbi.nlm.nih.gov/m/pubmed/11420057/

Conceivable but a stretch.

@macaroni has a lot of knowledge on the link between the immune system and hair loss.

 

[Maxxorr]

In a few weeks I will be put on Mirtazapine, a strong H1 anti-histamine. We will see...

 

[BaldyBalderBald]

I've mentioned this many times on this forum but keep getting ignored or ridiculed. The link between mast cells/immune system and hairloss is undeniable. I would bet any amount of money that an immune system dysfunction, which triggers an influx of mast cells (and therefore creates inflammation) creates a chain reaction of overproduction of PGD2 which both inhibits hair growth and causes it to miniaturize. PGD2 is only a component since removing PGD2 does not necessarily cause hair to grow back, but to me the link between hairloss and the immune system is pretty obvious.

• Mast Cells are the predominant source of PGD2.
• Mast Cells are known to develop in the microenvironment of Hair Follicles.
• PGD2 is known to inhibit hair growth

References:
"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"These data support the notion that Mast Cells function as hair cycle regulators and are involved in the control of HF regression." - https://www.ncbi.nlm.nih.gov/pubmed/9354767

"We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells." - https://www.ncbi.nlm.nih.gov/pubmed/24438498

"infiltrating lymphocytes and mast cells have been identified around the miniaturizing follicle (9), especially in the area of the stem cell–rich bulge area" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"We also noted a unique peak of PGD2 production within hours of depilation, which was not seen in the spontaneous hair cycle in Fig. 3B. This coincides with degranulation of mast cells observed previously after depilation" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes." - http://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

"Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2).[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells." - https://en.wikipedia.org/wiki/Prostaglandin_D2

"TNF was thought to be produced primarily by macrophages,[33] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[3] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[34]" - https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha

"Hair Follicles provide a unique microenvironment for local development of mast cells" - https://www.ncbi.nlm.nih.gov/pubmed/12738661

"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice." - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Interesting post, Seti/Fevi come and save us please

 

[Janko]

I've mentioned this many times on this forum but keep getting ignored or ridiculed. The link between mast cells/immune system and hairloss is undeniable. I would bet any amount of money that an immune system dysfunction, which triggers an influx of mast cells (and therefore creates inflammation) creates a chain reaction of overproduction of PGD2 which both inhibits hair growth and causes it to miniaturize. PGD2 is only a component since removing PGD2 does not necessarily cause hair to grow back, but to me the link between hairloss and the immune system is pretty obvious.

• Mast Cells are the predominant source of PGD2.
• Mast Cells are known to develop in the microenvironment of Hair Follicles.
• PGD2 is known to inhibit hair growth

References:
"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"These data support the notion that Mast Cells function as hair cycle regulators and are involved in the control of HF regression." - https://www.ncbi.nlm.nih.gov/pubmed/9354767

"We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells." - https://www.ncbi.nlm.nih.gov/pubmed/24438498

"infiltrating lymphocytes and mast cells have been identified around the miniaturizing follicle (9), especially in the area of the stem cell–rich bulge area" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"We also noted a unique peak of PGD2 production within hours of depilation, which was not seen in the spontaneous hair cycle in Fig. 3B. This coincides with degranulation of mast cells observed previously after depilation" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes." - http://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

"Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2).[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells." - https://en.wikipedia.org/wiki/Prostaglandin_D2

"TNF was thought to be produced primarily by macrophages,[33] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[3] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[34]" - https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha

"Hair Follicles provide a unique microenvironment for local development of mast cells" - https://www.ncbi.nlm.nih.gov/pubmed/12738661

"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice." - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

I have too written here my derm theory, that allergy and hair loss are quite connected. As he said he often see balding in young patients who also have some allergy. It would be kind of logical assume, that hair loss is not just like nothing, but also connected to some health issue.

 

[BaldyBalderBald]

I have too written here my derm theory, that allergy and hair loss are quite connected. As he said he often see balding in young patients who also have some allergy. It would be kind of logical assume, that hair loss is not just like nothing, but also connected to some health issue.

I myself don't suffer from any allergy despite having a quite agressive hairloss, what's interesting is how the immune system is liberating a huge amounts of allergic and inflammatory markers.Maybe some immuno suppressive drugs like those JAK inhibitors can be useful for Androgenetic Alopecia after all, fingers crossed

 

[dermrafok]

I've mentioned this many times on this forum but keep getting ignored or ridiculed. The link between mast cells/immune system and hairloss is undeniable. I would bet any amount of money that an immune system dysfunction, which triggers an influx of mast cells (and therefore creates inflammation) creates a chain reaction of overproduction of PGD2 which both inhibits hair growth and causes it to miniaturize. PGD2 is only a component since removing PGD2 does not necessarily cause hair to grow back, but to me the link between hairloss and the immune system is pretty obvious.

• Mast Cells are the predominant source of PGD2.
• Mast Cells are known to develop in the microenvironment of Hair Follicles.
• PGD2 is known to inhibit hair growth

References:
"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"These data support the notion that Mast Cells function as hair cycle regulators and are involved in the control of HF regression." - https://www.ncbi.nlm.nih.gov/pubmed/9354767

"We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells." - https://www.ncbi.nlm.nih.gov/pubmed/24438498

"infiltrating lymphocytes and mast cells have been identified around the miniaturizing follicle (9), especially in the area of the stem cell–rich bulge area" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"We also noted a unique peak of PGD2 production within hours of depilation, which was not seen in the spontaneous hair cycle in Fig. 3B. This coincides with degranulation of mast cells observed previously after depilation" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes." - http://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

"Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2).[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells." - https://en.wikipedia.org/wiki/Prostaglandin_D2

"TNF was thought to be produced primarily by macrophages,[33] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[3] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[34]" - https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha

"Hair Follicles provide a unique microenvironment for local development of mast cells" - https://www.ncbi.nlm.nih.gov/pubmed/12738661

"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice." - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Big pharma are you watching this? You need it.

 

[inmyhead]

So if that is true, jak would work for this sh*t?

 

[Janko]

I myself don't suffer from any allergy despite having a quite agressive hairloss, what's interesting is how the immune system is liberating a huge amounts of allergic and inflammatory markers.Maybe some immuno suppressive drugs like those JAK inhibitors can be useful for Androgenetic Alopecia after all, fingers crossed

I did not know I have an allergy too. No nausea, no respiratory problems, just from time to time I started to cough. No big deal. It was one week when I was coughing like idiot and my Doctor told me I am not ill and to visit pulmonary. There they sent me to allergologist. There they to my surprise found, that I am allergic to mites and that I have asthma. As the doctor told me. Probably because I am incredibly active in sports it did affect me, but not the way I would have a breathing problem on daily basics.
What amaze me is, that I started big 3 and asthma treatment at the same time. After seven months I got wonderful results. I went from nw3,5 to thick Norwood 2,5 and velus hair in Norwood 1,5. After that my Doctor recommended to stop using the inhalator with cortiocosteroids. Two months after a huge shed occured and half year from that my hair was quite bad. Not as bad as before, but back to nw3. So i tried adding oral finasteride. Huge mother fakin shed which is lasting until today. I wonder if the inhalator did the work. (I used duoresp - budesonide,formoterol fumarate dihydrate)

 

[jamesbooker1975]

I've mentioned this many times on this forum but keep getting ignored or ridiculed. The link between mast cells/immune system and hairloss is undeniable. I would bet any amount of money that an immune system dysfunction, which triggers an influx of mast cells (and therefore creates inflammation) creates a chain reaction of overproduction of PGD2 which both inhibits hair growth and causes it to miniaturize. PGD2 is only a component since removing PGD2 does not necessarily cause hair to grow back, but to me the link between hairloss and the immune system is pretty obvious.

• Mast Cells are the predominant source of PGD2.
• Mast Cells are known to develop in the microenvironment of Hair Follicles.
• PGD2 is known to inhibit hair growth

References:
"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"These data support the notion that Mast Cells function as hair cycle regulators and are involved in the control of HF regression." - https://www.ncbi.nlm.nih.gov/pubmed/9354767

"We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells." - https://www.ncbi.nlm.nih.gov/pubmed/24438498

"infiltrating lymphocytes and mast cells have been identified around the miniaturizing follicle (9), especially in the area of the stem cell–rich bulge area" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"We also noted a unique peak of PGD2 production within hours of depilation, which was not seen in the spontaneous hair cycle in Fig. 3B. This coincides with degranulation of mast cells observed previously after depilation" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes." - http://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

"Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2).[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells." - https://en.wikipedia.org/wiki/Prostaglandin_D2

"TNF was thought to be produced primarily by macrophages,[33] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[3] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[34]" - https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha

"Hair Follicles provide a unique microenvironment for local development of mast cells" - https://www.ncbi.nlm.nih.gov/pubmed/12738661

"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice." - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Amen to that. That is why Cyclorporin works on hair loss. Same as tacrolimus. Problem is that this drug have an incredible high molecular weight ( more than 800 daltons ) meaning it don't works when you apply it as topical.
Topical corticoids, even when they block all the prostaglandines also stop hair loss when you apply it topical in fact, that is why the Dr. Lee products had such good results, cause he included dexametasone.

Fevipiprant, in 2019, will be the answer. May be we are lucky enought to get this drug as topical without much systemic absorption .

And, don't overrated Cetirizine as topical ( keep in mind that to have the same results as topical, you will need much higher dose than the common 10mg oral dose ) .

 

[IdealForehead]

I've mentioned this many times on this forum but keep getting ignored or ridiculed. The link between mast cells/immune system and hairloss is undeniable. I would bet any amount of money that an immune system dysfunction, which triggers an influx of mast cells (and therefore creates inflammation) creates a chain reaction of overproduction of PGD2 which both inhibits hair growth and causes it to miniaturize. PGD2 is only a component since removing PGD2 does not necessarily cause hair to grow back, but to me the link between hairloss and the immune system is pretty obvious.

• Mast Cells are the predominant source of PGD2.
• Mast Cells are known to develop in the microenvironment of Hair Follicles.
• PGD2 is known to inhibit hair growth

References:
"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"These data support the notion that Mast Cells function as hair cycle regulators and are involved in the control of HF regression." - https://www.ncbi.nlm.nih.gov/pubmed/9354767

"We found significantly more dermal mast cells immunoreactive for prostaglandin D-synthase in the vertex compared to the lateral aspects of the scalp, with a decrement that spatially approximated the pattern of androgenetic alopecia. This difference was present in both balding and non-balding scalps and was independent of gender. Dual labeling established dermal cells expressing prostaglandin D-synthase as mast cells." - https://www.ncbi.nlm.nih.gov/pubmed/24438498

"infiltrating lymphocytes and mast cells have been identified around the miniaturizing follicle (9), especially in the area of the stem cell–rich bulge area" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"We also noted a unique peak of PGD2 production within hours of depilation, which was not seen in the spontaneous hair cycle in Fig. 3B. This coincides with degranulation of mast cells observed previously after depilation" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Prostaglandin D2 (PGD2) is the predominant prostaglandin product released by mast cells. It is found prevalently in the central nervous system and peripheral tissues, where it performs both inflammatory and normal processes." - http://www.mastattack.org/2015/04/mast-cell-mediators-prostaglandin-d2-pgd2/

"Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2).[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, and basophils. In mammalian organs, large amounts of PGD2 are found only in the brain and in mast cells." - https://en.wikipedia.org/wiki/Prostaglandin_D2

"TNF was thought to be produced primarily by macrophages,[33] but it is produced also by a broad variety of cell types including lymphoid cells, mast cells, endothelial cells, cardiac myocytes, adipose tissue, fibroblasts, and neurons.[3] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). In the skin, mast cells appear to be the predominant source of pre-formed TNF, which can be released upon inflammatory stimulus (e.g., LPS).[34]" - https://en.wikipedia.org/wiki/Tumor_necrosis_factor_alpha

"Hair Follicles provide a unique microenvironment for local development of mast cells" - https://www.ncbi.nlm.nih.gov/pubmed/12738661

"[Mast Cells] are functionally important modulators of hair follicle cycling, specifically during anagen development." - https://www.ncbi.nlm.nih.gov/pubmed/8528600

"During normal follicle cycling in mice, Ptgds and PGD2 levels increase immediately preceding the regression phase, suggesting an inhibitory effect on hair growth. We show that PGD2 inhibits hair growth in explanted human hair follicles and when applied topically to mice." - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

"Our studies show that prostaglandins are dysregulated in Androgenetic Alopecia, the most common type of hair loss in men. Specifically, PGD2 inhibits hair growth and thus represents a negative counterbalance to the positive effects on hair growth shown for PGE2 and PGF2α" - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/

Cool. Never saw you post about it before. Have you been following all our discussions on topical cetirizine/desloratadine lately?

Mast cells are critical & it's about a lot more than just pgd2.

Some of the theory is discussed especially on the second page here:
https://www.hairlosstalk.com/intera...ol-will-make-your-face-look-like-sh*t.109593/

 

[ManinBlack]

I have seasonal allergies and I also got an allergy test a while ago which said that I was sensitive to a lot of foods. However, I actually have no trouble eating them and it seems like a lot of work to try to avoid them all because they might be affecting my hair. Do you think I should try changing my diet? I am already on cetirizine oral btw.

 

[NimuDash]

I have an uncurable autoimmune disease, this may be 100 percent true since I started losing since 14.

 

[livinginfear93]

It has to be pretty complicated. I have a disease called Mast Cell Activation Syndrome, which causes mast cells to be trigger happy and release extra mediators (like histamine, PGD2, etc) into the blood stream, sometimes resulting in anaphylaxis. I have all sorts of health issues that stem from this illness.

But I have a thick Norwood 1-1.5 at 25, lost a little bit at the temples and have a bald maternal grandfather (see username) and an obsession with the science of hairloss. If systemic PGD2 were really the crucial answer, I'd be slick bald, bc my body releases excessive amounts every day (as shown through blood and urine tests).


It could be that some people have mast cells in the hair follicles and some don't. Seems completely plausible to me. As different people have them in different locations. It also may mean that some people have specific mutations of the hair follicle mast cells that cause them to release extra mediators/PGD2, hence the elevated levels in the scalp. It could be that different people develop the mutation randomly as they age, hence the random onset of Male Pattern Baldness.


I have noticed some women with my illness and elevated PGD2 levels who go on to develop significant balding.

 

[arnoldd]

It has to be pretty complicated. I have a disease called Mast Cell Activation Syndrome, which causes mast cells to be trigger happy and release extra mediators (like histamine, PGD2, etc) into the blood stream, sometimes resulting in anaphylaxis. I have all sorts of health issues that stem from this illness.

But I have a thick Norwood 1-1.5 at 25, lost a little bit at the temples and have a bald maternal grandfather (see username) and an obsession with the science of hairloss. If systemic PGD2 were really the crucial answer, I'd be slick bald, bc my body releases excessive amounts every day (as shown through blood and urine tests).


It could be that some people have mast cells in the hair follicles and some don't. Seems completely plausible to me. As different people have them in different locations. It also may mean that some people have specific mutations of the hair follicle mast cells that cause them to release extra mediators/PGD2, hence the elevated levels in the scalp. It could be that different people develop the mutation randomly as they age, hence the random onset of Male Pattern Baldness.


I have noticed some women with my illness and elevated PGD2 levels who go on to develop significant balding.

interesting bro. yes , maybe like there are people not sensitive to dht , the same could happend with infllammatory mediators ( pgd2 )