Exploring The Hormonal Route. Hair=life.

[SnortingFinasteride]

does estradiol reduces the same androgens like cpa does?

Much better. Estradiol is literally the Testosterone killer

Prolactin can cause hair loss. CPA causes prolactin levels to skyrocket. Also, it causes Vitamin B12 deficiency and depression. CPA should honestly be banned worldwide. It serves no purpose when better things are already on the market

You're better off being on E and Bicalutamide

 

[sg2000]

im already on e2 injections plus cpa dutasteride and oral minoxidil.

 

[sg2000]

im afraid of stopping cpa all of sudden…Im afraid of losing hairr

 

[BeardCombover]

soo my regimen will be 25mg cypro everyday + 4mg e every 5 days + 0.5 duta once a week + 5mg oral minoxidil daily

Also curious as to why 0.5/w duta, seems too low of a dose.
Also, in addition to SnortingFinasteride's comments, 12.5mg is more than enough for 3 reasons:
1. Elevated prolactin. Its a stress hormone that can elevate adrenal androgens and cortisole itself and cause oily skin and hairloss.
2. 25mg of CPA is enough to cause antagonism of androgen receptors. Which is bad, because its too low of a dose to provide stable antagonism (like bica) and might cause upregulation.
3. Elevated SHBG, which reduces synergy with E as antigonadotropins by lowering free E. It could possibly also unbind E from SHBG as seen on monkeys, but again, only at much higher doses.
Overall, high dose is counterproductive if you take CPA with enough E for its antigonadotropic properties. And if you use it for AR antagonism, or glucocorticoid activity you need a pretty high dose of 100mg+.
Also, for anyone that takes CPA with food, thats a bad idea, cause it passes blood-brain barrier far easier this way, and moreover less effective than while taken after food.

Im adding 0.5 mg dexamethasone 2x a day

There are number of reasons why you should not do it without taking HPA axis/adrenal bloodtests. I'll comment on that later today if have enough time.

 

[sg2000]

why bridge and noha and other got results even with high dose of cpa?
@BeardCombover do you think its ok to reduce it to 3 times a week (75 mg)?

 

[SnortingFinasteride]

im already on e2 injections plus cpa dutasteride and oral minoxidil.

What is your e2 injection dosage ? Stay on Dutasteride, stop CPA, add Bicalutamide

 

[sg2000]

16-15 mg every 2 weeks.
Im not gonna add bica tbh bro
0.4 ml every 2 weeks

 

[SnortingFinasteride]

16-15 mg every 2 weeks.
Im not gonna add bica tbh bro
0.4 ml every 2 weeks

Which E2 ? E Valerate or Cypionate or Enanthate ?

 

[BeardCombover]

Im adding 0.5 mg dexamethasone 2x a day

Ok, HPA state is usually tested with ACTH, Cortisole (+urinal test for free cortisole if possible), DHEA-S. Its also might be good to test to exclude any kind of Cushing's syndrome, which often causes diffuse thinning. Also, you cant treat Cushing's with corticosteroids.
Other, and most probable possibility is non-classical CAH, which is caused by enzyme mutations and leads to:
- 11β-Hydroxylase deficiency. Tested with 11-deoxycortisol. Its better as a simulation test, but just knowing your serum 11-deoxycortisol level is also good.
- 21-Hydroxylase deficiency. You need to test 17-OHP for that, thats the main marker. It also often causes backdoor pathway btw, so you better also test DHT and 3α-diol-g as well.
- 3β-Hydroxysteroid dehydrogenase deficiency. Usually tested with DHEA and Pregnenolone, but also 17α-hydroxypregnenolone if possible.
Also, i'd test Androstenedione as a universal marker, and IGF-1. Also standard set: T, free T, E2, Estrone, SHBG, LH. Also CMP, CBC panels, lipids, thyroid. Thyroid and Estrone might be overkill, but good to know regardless.

 

[BeardCombover]

why bridge and noha and other got results even with high dose of cpa?
@BeardCombover do you think its ok to reduce it to 3 times a week (75 mg)?

The best dose that worked for me is 12.5mg EOD. Im pretty sure you dont need more (if any at all) with your E dose.
6.25mg EOD did more harm than good in my case.

16-15 mg every 2 weeks.
Im not gonna add bica tbh bro
0.4 ml every 2 weeks

You dont need to note the volume if you already mentioned the mass. And btw, until you change to every 10 days, dont ask me anything. =D

 

[sg2000]

Which E2 ? E Valerate or Cypionate or Enanthate ?

enanthate.Do you take hrt?

 

[SnortingFinasteride]

enanthate.Do you take hrt?

Yes. I take 8 mg E sublingually

E enanthate half life is 7 days. You should inject once a week, not every 2 weeks

 

[sg2000]

Yes. I take 8 mg E sublingually

E enanthate half life is 7 days. You should inject once a week, not every 2 weeks

im just following the box instructions

 

[sg2000]

im taking double the dosage

 

[SnortingFinasteride]

im just following the box instructions

Follow actual recommendations. Lower your dosage a bit (11-12 mg) and inject every week. You'll have more consistent Estradiol levels and less high peak / low trough

 

[SnortingFinasteride]

im taking double the dosage

You are free to search about this and see for yourself. Injecting Enanthate every 2 weeks makes E levels more erratic

 

[sg2000]

my levels were 429 pg ml after 14 days of the prevoius injection

 

[pentobean]

And could a topical finasteride solution work better then orally if I had reflex from oral finasteride?

Don’t waste your money on topical finasteride, if he

Do you like brain tumours ? Do you want to breastfeed ? Cyproterone is very good for both of these things

Estradiol is sufficient to be anti-androgenic. No need for CPA. CPA can even activate the androgen receptors when Testosterone is very low in the body. This is counter-productive to your goals I would assume

so your saying that CPA isn’t worth it because it has side effects.

if your already balding due to androgens, wouldn’t it be best to lower androgens as much as you could, supplement it with estrogen and see what happens?

 

[SnortingFinasteride]

so your saying that CPA isn’t worth it because it has side effects.

if your already balding due to androgens, wouldn’t it be best to lower androgens as much as you could, supplement it with estrogen and see what happens?

i don't consider CPA side effects to just be mere downplayed "side effects". These are brain tumours we are talking about...

And no. CPA isn't worth it because Estradiol exists, and it is vastly supperior to a synthetic progestogen in every means. If a man was to take CPA for hairloss, it would be a moot point because having both Low T and Low E causes hairloss. That, plus CPA triggers depressive episodes, which is what a man dealing with hairloss should *not* experience

So, it's best to take Estradiol + actual good anti-androgens, like Bicalutamide

CPA maximally lowers androgens by 70%. Which is the best progestogens can do without estradiol. Estradiol alone lowers androgens by 90%+ in adequate levels

 

[Dav1234]

i don't consider CPA side effects to just be mere downplayed "side effects". These are brain tumours we are talking about...

And no. CPA isn't worth it because Estradiol exists, and it is vastly supperior to a synthetic progestogen in every means. If a man was to take CPA for hairloss, it would be a moot point because having both Low T and Low E causes hairloss. That, plus CPA triggers depressive episodes, which is what a man dealing with hairloss should *not* experience

So, it's best to take Estradiol + actual good anti-androgens, like Bicalutamide

CPA maximally lowers androgens by 70%. Which is the best progestogens can do without estradiol. Estradiol alone lowers androgens by 90%+ in adequate levels

But Bica doesn’t truly lower testerone it causes up regulating so if you already had reflex from finasteride then bica’s upregulation would probably have a similar effect despite using estrogen.