2 types of ALPHA

[airtas]

ok im a lil confused PROPECIA only blocks one type of enzyme?


is the other necessary to be blocked?

 

[Matgallis]

I had read somewhere that type-I was responsible for 30-40% of DHT related hairloss while the other 60-70% is type-II.

finasteride doesn't necessaryly block type-I, I believe it causes the body to produce less of it (don't quote me on this)

 

[airtas]

hmmm

so based on that, finasteride wont stop hair loss if there is still dht in the body

 

[Guest]

Re: hmmm

so based on that, finasteride wont stop hair loss if there is still dht in the body

you need some DHT for other body fuctions.

 

[jimmystanley]

depends on how sever your hair loss is. Try a topical as well...like revivogen.

 

[gonna_win]

im pretty sure when i say this but i recomend you do some research yourself. finasteride works in type 2 DHT not type 1, it is type two that causes the hairloss. it works by inhibiting the enzyme 5-alpha reductase which converts testosterone to DHT

 

[Chujgcha]

...

 

[airtas]

how often

depends on how sever your hair loss is. Try a topical as well...like revivogen.

does one use revivogen?

 

[airtas]

im pretty sure when i say this but i recomend you do some research yourself. finasteride works in type 2 DHT not type 1, it is type two that causes the hairloss. it works by inhibiting the enzyme 5-alpha reductase which converts testosterone to DHT

what is type one enzyme for then?

 

[George Costanza]

"Recently, two isoenzymes of 5a-reductase have been identified in human tissue. The type 1 isoenzyme is found in scalp skin, whereas 5a-reductase type 2 is the predominant form in prostate.

If that's true then drink your green tea because it's suppose to be a type 1 inhibitor!

 

[HairlossCA]

Hey jimmystanley:

You have a very similar regimen to what I am trying, I just added Revivogen about a month ago.

How long have you been on Revivogen and how is this regimen working out for you? Are you at least maintaining?

Thanks-

 

[jimmystanley]

i have been on finasteride for about a year now, i started to maintain after 8 months...so i lost for 8 months. however, i still continued to shed day by day. I've only been using revivogen for about 3 weeks. i know it's too early to make an assesment but i would say it has seriously slowed down the shedding. i'll see around 10-15 a day now. before it was a lot more. My goal (hope) is to stop dht related shedding and regain what i had 2 years ago when it looked like everyone elses. How are u doing after a month?

 

[Bryan]

The bottom line is that the type of 5a-reductase in hair follicle dermal papilla cells appears to be almost exclusively the type 2 version. That's why finasteride works against hairloss, and why specific type 1 inhibitors haven't worked very well in either human or stumptailed macaque tests.

Bryan

 

[airtas]

The bottom line is that the type of 5a-reductase in hair follicle dermal papilla cells appears to be almost exclusively the type 2 version. That's why finasteride works against hairloss, and why specific type 1 inhibitors haven't worked very well in either human or stumptailed macaque tests.

Bryan

ok so type 1 doesnt reallt need to be blocked?

 

[HairlossCA]

Revivogen: It's very hard to say at the one month point. I want to beleive that it's working and it does seem like I am losing less hair, but this is totally inconclusive. I will take a more intensive look after the 6 month point and then the year point and thereupon decide to shelf it or not. If I can simply maintain my haircount then I will be thrilled.

Please let the forum know how it turns out for you at the 6 month/Year periods. Let's hope we fall into the lucky 70% responder category!

 

[Bryan]

ok so type 1 doesnt reallt need to be blocked?

I'll hedge my bet just a little by saying that it isn't nearly as important for hairloss as the type 2 enzyme!

Bryan

 

[Whoome?]

bryan thats what i thought too. but then what is Chujgcha talking about?

Quote from regrowth.com:

"Recently, two isoenzymes of 5a-reductase have been identified in human tissue. The type 1 isoenzyme is found in scalp skin, whereas 5a-reductase type 2 is the predominant form in prostate.

according to his post its exactly opposite.

 

[Bryan]

The statement "The type 1 isoenzyme is found in scalp skin..." is rather outdated information!

BOTH types are found in human skin: type 1 in sebaceous glands, and type 2 in hair follicle dermal papillae. For hairloss specifically, the type 2 form is much more important.

Bryan

 

[Whoome?]

ahhh i see.. since type 1 is found in the seb glands, would that explain these numerous claims that dutasteride acctually cleared away acne, and a few who saw better results from dutasteride rather than finasteride.

 

[airtas]

The statement "The type 1 isoenzyme is found in scalp skin..." is rather outdated information!

BOTH types are found in human skin: type 1 in sebaceous glands, and type 2 in hair follicle dermal papillae. For hairloss specifically, the type 2 form is much more important.

Bryan

what does the type one enzyme do? its purpose?