Im starting to think, if you shaved your head BALD and used a dense roller I could see this being functional. I just don't think for the average Joe, and I say that since some of you swear youre getting results, the wound just isn't sufficient enough. I cant see the 192 even grinding hard, which I am being enough. I mean I am BARELY bleeding anymore. I will say I bleed quicker but my clotting happens so fast that I cant see the impact being enough and I cant go any harder since
1) my hair is in the way
2) I will scab my head and look retarded at work
Also perhaps some of you can produce enough fgf9 and Wnt to get "something" out of this
while other of us might not and may even just have high levels of the other protein prostaglandin D (I just read about that, dont think Im acting like a smarty pants)
For me Ive noticed no postive results yet and just finished another roll last night. I have in fact seen the opposite and my frontal region looks thinner than when I started. Whether this is due to rolling who knows.
That's what I think. I mean the science behind wounding is solid. Cotsarelis also proved that we don't have a lot of gamma delta T cells that are responsible for the growth factors that signal the wnt pathway. I believe the ones that do not get benefit from DRing should produce more COX-1 than necessary that result in a higher PGD2 level. Hence, even though the skin heals itself, hair growth is blocked.
These are all proven stuff, but what I think most people are really frustrated about is that scientists such as Cotsarelis who are so knowledgeable and talented in their fields are not eager to get their hands dirty to find the safest COX-1 blocker or the growth factor promoter to fight this thing. They would rather spend their time figuring out the relationship between DHT and increased COX-1 levels and get the full picture. This makes everything slower and people are desperate to try and find the best formula to try on themselves.
We have come a long way. I remember my earliest times in this forum (probably close to a year). People were desperate to try everything (different kinds of unproven DHT blockers at first, then PGD2 blockers, OC, natural remedies, etc) they could find and hoped for the best. Now, we know what might and should be of benefit to us, but we are not eager to try them because we know the solution will come and we are thinking of the safety profiles, the risk of cancer, etc. That's my reasoning that people are hesitant to mess with C0X-1 blockers, FGF-9 etc.
If I were in your shoes, I would go for something heavier to wound (2 or maybe a 2.5 mm DR). I also might increase the strength of minoxidil (might go up till 15%). If that also doesn't work, I would then experiment with either the safest proven FGF-9 promoter or COX-1 blocker (if you are not into blocking DHT by using finasteride or such products). While researching for COX-1 blockers I came up with this site (in like 5 minutes) (
http://www.scbt.com/chemicals-table-cox_1_inhibitors.html). Some of these listed COX-1 inhibitors are proven as safe (Aspirin or acetaminophen being some of the ones). I would start using one or a few of them. If you have a chem background or know someone you can also prepare a topical which is all the better.
Now you might say that this is all bs, but that's what I would do if I were you. So just trying to be helpful here.
