Delivery it's not hard at all. The 500 Dalton rule has always been misinterpreted.
We have data showing that it lowers s app DHT even when dissolved in Trichosol, with no penetration enhancer. So if you get liposomes you will have a really good amount of local DHT inhibition, with reduced systemic absorption.
All the data in studies that actually measured scalp DHT has shown a superiority of scalp inhibition when compared to oral, so I don't really know what's the deal with taking 5-ar inhibitors orally.
On top of that, dutasteride has a huge impact on sperm motility and quality, it's liver toxic, it can cause metabolic syndrome and it basically wipes out allopregnanolone in the brain.
What I always say is don't consider sexual sides like the only problem and the marker to take in account for treatment tolerability, rather check all your health markers for long term health. Few people on this forum do.