3 Months On Topical Dutasteride - Results

[HighPregnenolone]

Get your doctor do a prescription for you and order a liposomal version from Parati or any other compounding pharmacy that knows the stuff. You don't need to pay Lupanzula's fees or even worse 60 euro for a month supply. That's ridiculous.
They get it from Parati anyway and trying to make money out of it.

Recommended vehicle? Any other ingredients I should have them add?

Compounding pharmacy recommendations in USA?

Whole lot of open ended questions... I wanna get this video documentation going for the community. Some of your insight would be greatly appreciated dude. @Mustang

 

[Canuto]

Recommended vehicle? Any other ingredients I should have them add?

Compounding pharmacy recommendations in USA?

Whole lot of open ended questions... I wanna get this video documentation going for the community. Some of your insight would be greatly appreciated dude. @Mustang

I prefer a liposomal vehicle, due to enhanced absorption as shown in several studies and lower systemic absorption. But you can't avoid it completely and some will go systemic. My second favourite vehicle is Trichosol. Google it.

A compounding pharmacy in the USA would be MMA, but they are way more expensive than the Italian ones.
I'm telling you before jazz1 chimes in with his usual ad message from MMA.

 

[HighPregnenolone]

I prefer a liposomal vehicle, due to enhanced absorption as shown in several studies and lower systemic absorption. But you can't avoid it completely and some will go systemic. My second favourite vehicle is Trichosol. Google it.

A compounding pharmacy in the USA would be MMA, but they are way more expensive than the Italian ones.
I'm telling you before jazz1 chimes in with his usual ad message from MMA.

Thanks @Canuto. Pls hit my dm’s if you have a minute. Seems like you have some interesting input that could benefit this experiment.

MMA seems pretty sketchy to be honest and it doesn’t appear they sell a liposomal version.

Any way to get Pharmaci Parati in US or should I just pull trig on Alvi Armani’s batch if I can get ahold of them? I left them VM last week and haven’t heard back from them yet.

I appreciate you looking out. Stevie Wonder could see that Jazz1 is a shill :’) #inb4imaveteraninthiscommunity

Looking forward to hearing back and keeping y’all posted. Seems as if @Mustang is sick of all the skeptics here and is busy enjoying his newfound full head of hair.

 

[Canuto]

Thanks @Canuto. Pls hit my dm’s if you have a minute. Seems like you have some interesting input that could benefit this experiment.

MMA seems pretty sketchy to be honest and it doesn’t appear they sell a liposomal version.

Any way to get Pharmaci Parati in US or should I just pull trig on Alvi Armani’s batch if I can get ahold of them? I left them VM last week and haven’t heard back from them yet.

I appreciate you looking out. Stevie Wonder could see that Jazz1 is a shill :’) #inb4imaveteraninthiscommunity

Looking forward to hearing back and keeping y’all posted. Seems as if @Mustang is sick of all the skeptics here and is busy enjoying his newfound full head of hair.

Done.
Parati ships with DHL to the US, but you will need a doctor prescription to email to them and I think the shipment is 60 euro in the US.

 

[Selb]

Done.
Parati ships with DHL to the US, but you will need a doctor prescription to email to them and I think the shipment is 60 euro in the US.

Do you also use topical dutasteride? I wonder if it’s more effective at suppressing scalp dht compared to the oral AAs

 

[corkmeister]

Do you also use topical dutasteride? I wonder if it’s more effective at suppressing scalp dht compared to the oral AAs

Depends on how much you're using. Topical dutasteride has a more localized effect, so in that sense it's more effective at suppressing scalp dht. But you could probably achieve the same amount with oral, if your dose is high enough.

 

[Capone]

Get your doctor do a prescription for you and order a liposomal version from Parati or any other compounding pharmacy that knows the stuff. You don't need to pay Lupanzula's fees or even worse 60 euro for a month supply. That's ridiculous.
They get it from Parati anyway and trying to make money out of it.

Parati site is in Italian?

 

[Canuto]

Do you also use topical dutasteride? I wonder if it’s more effective at suppressing scalp dht compared to the oral AAs

Every topical 5-ar inhibitor will be more effective at suppressing DHT in the target tissue. It has been proven over and over again with all the drugs. I recently saw 2 studies done with topical tamoxifen and topical CPA (for other purposes than treating Androgenetic Alopecia) and the outcome was the same. If you add the fact that DHT is a paracrine hormone, ingesting oral 5-ar inhibitors to inhibit DHT formation in the scalp is plain dumb.

Parati site is in Italian?

Yes. You will need to send an email in English and they will reply to you, but they are usually a bit slow.

 

[Sanchez1234]

With oral finasteride I tried 3 different times.

The first time it was after a few months if I remember correctly. I developed Gyno on one side and was extremely tired all the time. I stopped and recovered within 3 months or less. Gyno had to be removed with surgery

The second time I took it I got immediate and unbearable prostate pain after 2 days. I stopped immediately. The pain lasted about 4 months. I had no capability of having an erection and almost lost my girlfriend. It eventually got better.

The third time I tried it was topically and I was fine for a few weeks and then got very bad brain fog, I could not concentrate at all and was extremely dizzy at all times.

I also developed low T after years of usage. It wen't down from 900 ng/ml total test to 450 ng/ml in just 3 years. Not normal. There are several studies that show continuous use of oral anti androgens reduces testosterone in time despite it raising free test initially as less converts into DHT.

With topical dutasteride I have no brain fog, no fatigue and I have morning wood. My libido might be slightly lower but my test is also very low and I am older so it is to be expect.

I am starting TRT today. See what happens

Did you got results on oral finasteride?

 

[Sanchez1234]

OP great thread @Mustang

So i just read the whole thread and i understand that you used 1% (10mg) the first months and later you used 0.1% (1mg) to maintain. Am i understanding correct?

 

[Mustang]

Yes, I have used several dosages to see how it affected serum DHT, hair loss and sides.
You can get away with 0.1% (2ml) thus 0.2% and still reduce high amounts of scalp DHT

 

[Capone]

Yes, I have used several dosages to see how it affected serum DHT, hair loss and sides.
You can get away with 0.1% (2ml) thus 0.2% and still reduce high amounts of scalp DHT

Any samples?

 

[jamesbooker1975]

I really don't uderstand the high dose. Why 1 % ? This is the big problem . For example, topical finasteride must be 0.1 % , However I see 2.5 %, 5 % , of course it will be side effects .
And Topical Dutasteride could even be 0.05 % . Why 1 % ? that is a gram , 1000 mg, that is 2000 capsules of Dutasteride every 100 ml of lotion ! Insane . That is the problem with docs, they have no idea at all about pharmacology . So , If you take it orally, you will use 365 capsules in a whole year .

 

[jamesbooker1975]

I am sorry, I think I missed something: are you a PFS sufferer? Otherwise, why do you want to implement TRT?

Did you get your homones checked while on fina/after fina/after duta?

That's good news you don't get sides with topical duta!



Actually, it's been discussed in another thread. Topical dutasteride could be a more viable option than topical finasteride. It seems the drug is not particularly going systemic (because of the 500 daltons rule). For products that need to get to the lower layers of skin, molecular weight should be below 500 Daltons (which is the case for finasteride but not dutasteride).

Hence my question about the carrier. If it's a liposomal solution, I could very well see this working. Also, do you dermaroll?



bump

Last but not least, there was an interesting study published in a "not well renowned" journal. I will re-attach it. They used micro-needling to force the penetration in duta in the skin. Serum DHT seemed to remain stable.

Microneeding will increase systemic absortion plus there is always the chance of infection .

 

[Mustang]

I really don't uderstand the high dose. Why 1 % ? This is the big problem . For example, topical finasteride must be 0.1 % , However I see 2.5 %, 5 % , of course it will be side effects .
And Topical Dutasteride could even be 0.05 % . Why 1 % ? that is a gram , 1000 mg, that is 2000 capsules of Dutasteride every 100 ml of lotion ! Insane . That is the problem with docs, they have no idea at all about pharmacology . So , If you take it orally, you will use 365 capsules in a whole year .

Not a big problem with Dutasteride. Done the bloodwork.
Docs know about pharmacology.
Big problem with Finasteride.

 

[Canuto]

I really don't uderstand the high dose. Why 1 % ? This is the big problem . For example, topical finasteride must be 0.1 % , However I see 2.5 %, 5 % , of course it will be side effects .
And Topical Dutasteride could even be 0.05 % . Why 1 % ? that is a gram , 1000 mg, that is 2000 capsules of Dutasteride every 100 ml of lotion ! Insane . That is the problem with docs, they have no idea at all about pharmacology . So , If you take it orally, you will use 365 capsules in a whole year .

1% is 10 mg, not a 1000 mg.

 

[jamesbooker1975]

1% is 10 mg, not a 1000 mg.

No, 1 % means 1 gram every 100 ml .

Formulas used to describe solutions

"A one percent solution is defined as 1 gram of solute per 100 milliliters final volume. For example, 1 gram of sodium chloride, brought to a final volume of 100 ml with distilled water, is a 1% NaCl solution. To help recall the definition of a 1% solution, remember that one gram is the mass of one milliliter of water. The mass of a solute that is needed in order to make a 1% solution is 1% of the mass of pure water of the desired final volume. Examples of 100% solutions are 1000 grams in 1000 milliliters or 1 gram in 1 milliliter."

But, most doctors will do the math in the same way you did it and that is the problem.

 

[Mustang]

Nobody is applying 100ml.

 

[jamesbooker1975]

Nobody is applying 100ml.

Jesus dude what is wrong with you ? Of course not, he is applying 2ml, that 2ml will contain 20mg of dutasteride, means everytime he apply that 1 % lotion, is like using 40 dutasteride AVODART or whatever you want to call it capsules each time he apply the lotion.

Jesus dude, really, you have bigger problem in your head than your hair .

 

[Mustang]

Leave Jesus and dude out of it. Speak normal and be respectful. You are the one being schooled here, not the other way around. Be humble and learn.

I prepare my own topical dutasteride and have used doses up to 50MG. That is 100 times the oral dose. I have applied 5ml of 1% concentration. I have also used other's topical dutasteride (liposomal, non liposomal, etc..) made in different pharmacies.

It has been explained countless of times on why it does not become highly vascularized and bloodwork has been done by many to prove it. Be happy this is a thing.

Just because YOU don't understand it doesn't mean it's not how it works on most people.

Buy some, use it. Do bloodwork, come back. Share.

Make yourself useful.