A lot of complainers in this section

[masculineyourheart]

... but he still looks like a tosser.

 

[Dogs3]

JWM, Ive been on dutasteride for about 3.5 months now. I take a .5 pill of genuine avodart through prescription once per day.

I was on propecia for 10 months previously with solid results, but i wanted to ensure better results and for a longer period of time, so i took the chance to use avodart. So far, its been good, hair is looking good still, but its obviously too early to tell how its going to work fully. Ill give it a few more months and evaluate, but honostly, if i stayed where i am now, id be happy.

 

[Guest]

JWM, Ive been on dutasteride for about 3.5 months now. I take a .5 pill of genuine avodart through prescription once per day.

I was on propecia for 10 months previously with solid results, but i wanted to ensure better results and for a longer period of time, so i took the chance to use avodart. So far, its been good, hair is looking good still, but its obviously too early to tell how its going to work fully. Ill give it a few more months and evaluate, but honostly, if i stayed where i am now, id be happy.

Why are you using such a strong poison...Laser comb will work for you..Just use that..

 

[bubka]

JWM, Ive been on dutasteride for about 3.5 months now. I take a .5 pill of genuine avodart through prescription once per day.

I was on propecia for 10 months previously with solid results, but i wanted to ensure better results and for a longer period of time, so i took the chance to use avodart. So far, its been good, hair is looking good still, but its obviously too early to tell how its going to work fully. Ill give it a few more months and evaluate, but honostly, if i stayed where i am now, id be happy.

Why are you using such a strong poison...Laser comb will work for you..Just use that..

Or try a laser pointer, it is the same thing :jackit: :roll:

 

[Dogs3]

JWM, Ive been on dutasteride for about 3.5 months now. I take a .5 pill of genuine avodart through prescription once per day.

I was on propecia for 10 months previously with solid results, but i wanted to ensure better results and for a longer period of time, so i took the chance to use avodart. So far, its been good, hair is looking good still, but its obviously too early to tell how its going to work fully. Ill give it a few more months and evaluate, but honostly, if i stayed where i am now, id be happy.

Why are you using such a strong poison...Laser comb will work for you..Just use that..

Or try a laser pointer, it is the same thing :jackit: :roll:

lol, good idea Bubka...

Rambotera, your right, i dont know what i was thinking, ill start using the laserbrush and drop dutasteride and lose all the hair ive gained right away. thanks for bringing me to my senses

 

[Dogs3]

and rambotera, if lasercomb is working so well for you, why are you browsing the avodart section and critisizing it?

 

[bubka]

and rambotera, if lasercomb is working so well for you, why are you browsing the avodart section and critisizing it?

he is a troll who has been banned from this site at least four times

viewtopic.php?f=31&t=40845&st=0&sk=t&sd=a

 

[medmax84]

Dogs3

Good luck

i take today 1,25mg finasteride Morning and 1,25mg evening
i think that have a similar effect as dutasteride
the Half-time from finasteride is artificially longer


Timi

There is no reason to dose that often on finasteride. It has a flat dosing curve.. you're being wasteful and increasing the likelihood of side effects.

Half-life has nothing to do with dosage... What you're talking about is keeping the serum levels within therapeutic range. Because the drug is relatively inert in the body except for its role in DHT inhibition, this isn't a huge consideration. Propecia has a 48-hr half-life (or something similar) and 1mg of propecia daily is more than ample to get its full effects.

Basically, taking 5mg of proscar twice per day isn't going to do much more for hair loss than taking 1mg once daily.

Take more than this at your own risk.

 

[Timi]

Dogs3

Good luck

i take today 1,25mg finasteride Morning and 1,25mg evening
i think that have a similar effect as dutasteride
the Half-time from finasteride is artificially longer


Timi

There is no reason to dose that often on finasteride. It has a flat dosing curve.. you're being wasteful and increasing the likelihood of side effects.

Half-life has nothing to do with dosage... What you're talking about is keeping the serum levels within therapeutic range. Because the drug is relatively inert in the body except for its role in DHT inhibition, this isn't a huge consideration. Propecia has a 48-hr half-life (or something similar) and 1mg of propecia daily is more than ample to get its full effects.

Basically, taking 5mg of proscar twice per day isn't going to do much more for hair loss than taking 1mg once daily.

Take more than this at your own risk.

i am back to 1mg Daily
2x finasteride i had burning and Hot Skin in the right and left side Abdomen i think Kidney Problems
this Problems has begun after 2Years dutasteride with finasteride all the long Years no Problems
i hope my Kidney has no damage

I have tolerated dutasteride first than comes this Problems

and today finasteride makes the same symptoms

must go to a Doctor when not goes better

and
you say Propecia has a 48-hr half-life
i know 8 hr-half life!


Timi

 

[Bryan]

Propecia has a 48-hr half-life (or something similar).

Finasteride has a half-life of around 5-6 hours, depending on age. A bit shorter in younger men, a bit longer in older men. Here's an actual graph of finasteride levels in the blood during a 24-hour period after taking Proscar. Keep in mind that the scale used in the graph is logarithmic:

http://img218.imageshack.us/img218/7561/fin5bfx1.jpg

The graph shows that finsteride levels in the blood drop by an order of magnitude (or more) after 24 hours.

 

[medmax84]

Propecia has a 48-hr half-life (or something similar).

Finasteride has a half-life of around 5-6 hours, depending on age. A bit shorter in younger men, a bit longer in older men. Here's an actual graph of finasteride levels in the blood during a 24-hour period after taking Proscar. Keep in mind that the scale used in the graph is logarithmic:

http://img218.imageshack.us/img218/7561/fin5bfx1.jpg

The graph shows that finsteride levels in the blood drop by an order of magnitude (or more) after 24 hours.

Turns out I misunderstood what I'd been reading and I apologize for perpetuating misinformation. The truth is that the majority of finasteride would be out of your system within 48 hours. That is a marked difference from half-life, and a mistake that I should not have made.

I sincerely apologize and will make a good effort not to allow this to happen again. :badmood:


That said, you must consider the therapeutic range of a DHT inhibitor. Finasteride may inhibit a considerable proportion of DHT long after several half-lives have passed. Unfortunately, I do not know these exact values, so this is a little bit of speculation.

However, it has been shown that as little as .25 mg of propecia is as efficacious as 1 mg taken daily in some patients. This leads me to believe that finasteride effectively inhibits DHT after several half lives have elapsed. While I am not a physician yet, Dr. Rassman from TheBaldingBlog has reported success at significantly lower daily doses and has stated that increasing dosage and frequency will not be more effective at preventing or reversing hair loss. :firing:

 

[Timi]

Propecia has a 48-hr half-life (or something similar).

Finasteride has a half-life of around 5-6 hours, depending on age. A bit shorter in younger men, a bit longer in older men. Here's an actual graph of finasteride levels in the blood during a 24-hour period after taking Proscar. Keep in mind that the scale used in the graph is logarithmic:

http://img218.imageshack.us/img218/7561/fin5bfx1.jpg

The graph shows that finsteride levels in the blood drop by an order of magnitude (or more) after 24 hours.

Bryan

You think better take 2x finasteride Morning and evening??
(Graphic)
http://img218.imageshack.us/img218/7561/fin5bfx1.jpg

Timi

 

[Bryan]

Turns out I misunderstood what I'd been reading and I apologize for perpetuating misinformation. The truth is that the majority of finasteride would be out of your system within 48 hours.

That's a little like saying that the majority of finasteride will be out of your system within 1 year! It's definitely a true statement, but it's misleading!

Again, the half-life of finasteride is known to be on the order of around 5-6 hours or so, depending on age; therefore, "the majority of finasteride" will literally be out of your system (out of the bloodstream, at least) after a period of only 5-6 hours, or thereabouts (for you young guys).

That said, you must consider the therapeutic range of a DHT inhibitor. Finasteride may inhibit a considerable proportion of DHT long after several half-lives have passed. Unfortunately, I do not know these exact values, so this is a little bit of speculation.

I'm not completely sure what you mean by "DHT inhibitor" and "inhibit DHT". Those aren't scientific terms, and they aren't used by the medical profession. Finasteride is a 5a-reductase inhibitor, not a "DHT inhibitor".

What you may not understand is that DHT levels remain low several days after finasteride is gone from the bloodstream, and the reason for that is that it takes a long time for the 5a-reductase enzyme to be replenished, once it's been irreversibly knocked-out by finasteride. The type 2 version of the enzyme (which is the one finasteride inhibits) is synthesized within cells only fairly slowly. The type 1 enzyme, on the other hand, is produced somewhat more rapidly.

However, it has been shown that as little as .25 mg of propecia is as efficacious as 1 mg taken daily in some patients. This leads me to believe that finasteride effectively inhibits DHT after several half lives have elapsed.

You need to understand that in the specific case of the phenomenon you mention above, the correct explanation has FAR more to do with the fact the type 2 enzyme takes a long time to regenerate (see my discussion just above), so taking even a smaller amount like 0.25 mg every day is sufficient to suppress DHT levels nearly as well as taking larger doses like 1 mg/day. The level of finasteride in the blood AT ANY ONE TIME during the day has relatively little to do with it. See what I'm saying?

While I am not a physician yet, Dr. Rassman from TheBaldingBlog has reported success at significantly lower daily doses and has stated that increasing dosage and frequency will not be more effective at preventing or reversing hair loss. :firing:

He errs when he says that it won't be MORE effective. It'll be more effective, but just slightly more effective. "The devil is in the details", as they say.

 

[Bryan]

You think better take 2x finasteride Morning and evening??

Slightly better, but it's probably not worth the extra expense, unless you're a rich man!

 

[Timi]

You think better take 2x finasteride Morning and evening??

Slightly better, but it's probably not worth the extra expense, unless you're a rich man!

Ok Thanks

what is with Fluta Topic
is that good for the Hairs or bad
(Genhair 2% Fluta)

or finasteride Topic?? is it good?
many says he have success from it

Bryan what is your Regime??

Timi

 

[Slartibartfast]

Howdy Bryan, great to have you back posting with us loons in the dutasteride. wing.

That is all.

 

[medmax84]

You think better take 2x finasteride Morning and evening??

Slightly better, but it's probably not worth the extra expense, unless you're a rich man!

I'm lucky you're here to parse my words. :hairy: I could have used the specific enzyme inhibition, but I was trying to keep it simple. He's pretty straightforward in saying taking more doses will be a waste because the difference will be miniscule if there is any at all and also highlights the likelihood of inreased sides. When a difference negligible, I tend to assume its not worth my time to acknowledge one at all. Perhaps this is negligent on my part, but I felt it was more important to underscore how superfluous the extra dose would be. I guess the proper thing to do would be to run the cost-benefit analysis right here on the screen, however I chose just to give the verdict: increasing your dosage is a waste and may cause more side effects.

TAKE IT AS DIRECTED. If you want to modify your dosage, it's best to consult a physician and get some baseline blood work done in case you begin to experience adverse reactions. 1 mg is what was approved for male pattern baldness, and it is at your own risk that you take a different dose than that.

If you're going to attack my medical understanding and saavy you're going to have to do better than this. Biochemical pathways are more complex than you are leading people to believe, and the term inhibit can be used more loosely than you let on. If I put a giant overturned tractor trailer in the middle of an intersection, yes you are directly blocking that intersection but you are also inhibiting cars' abilities to drive down the outflowing roadways. Thus by inhibiting the T>DHT enzyme (5-alpha reductase) you are inhibiting DHT production and "inhibiting DHT" becomes a quick and dirty way of discussing the matter. But you already knew that... you were just looking for a way to make me look stupid, when all I am trying to do is simply be a voice of reason in a forum where people are experimenting with potent, prescription medications.

 

[Bryan]

Thus by inhibiting the T>DHT enzyme (5-alpha reductase) you are inhibiting DHT production and "inhibiting DHT" becomes a quick and dirty way of discussing the matter. But you already knew that... you were just looking for a way to make me look stupid...

I wasn't trying to make you look stupid, I was trying to get you to use the proper terminology. On a highly technical forum like this one, I think we should use the same terminology that doctors and scientists use, or at least stick to it as much as possible. The term "DHT inhibitor" is vague and ambiguous. You don't see it used in medical textbooks or journals.

 

[medmax84]

Thus by inhibiting the T>DHT enzyme (5-alpha reductase) you are inhibiting DHT production and "inhibiting DHT" becomes a quick and dirty way of discussing the matter. But you already knew that... you were just looking for a way to make me look stupid...

I wasn't trying to make you look stupid, I was trying to get you to use the proper terminology. On a highly technical forum like this one, I think we should use the same terminology that doctors and scientists use, or at least stick to it as much as possible. The term "DHT inhibitor" is vague and ambiguous. You don't see it used in medical textbooks or journals.

Saw a hair transplant surgeon today who said propecia inhibited DHT :whistle:

I see your point, however.