"Accutane is chemically almost identical to Vitamin A. The daily dose of the drug is equivalent to about 200,000 International Units, which is about 40 times greater than the recommended daily intake of Vitamin A. To prevent the symptoms associated with vitamin A toxicity, individuals taking these medications should avoid taking supplemental vitamin A in doses exceeding 10,000 IU per day."
"Chronic vitamin A toxicity may occur following many months of daily intake of the vitamin in amounts exceeding 14,000 IU (4.2 mg or retinol equivalents) in children and 25,000 IU in adults, and is most likely to develop in individuals taking high doses of vitamin A compounds to treat skin disorders, or in those with poor liver function."
"US recommended dietary allowance (RDA) is 5000 IU (2500 IU for children aged 1-4 y).
- Supplements usually are 10,000-50,000 IU per capsule.
- Fish-liver oils may contain more than 180,000 IU/g.
-Acute toxic dose is 25,000 IU/kg, and chronic toxic dose is 4000 IU/kg every day for 6-15 months."