Alfatradiol, Aromatization of Hair Follicles and 3a-Diol-G.

[whitecoatblackhat]

Keto doesn't work for me and CB is too expensive. Have no other choice but try RU. Side effects should last a short period of time since half life is pretty short.

You can get CB at approx. 30 USD per gram if you buy 10g or more. Running it at 50-60mg per day is a good starting point, no need to go higher than that immediately. But if you've set your mind to RU, then just start at a very low dose and hopefully, it should be fine.

But just FYI, RU is a prodrug of cyanonilutamide, i.e. when you apply RU to your scalp, a percentage of that will convert into cyanonilutamide and leak into the serum. Cyanonilutamide resembles nilutamide quite a lot. Nilutamide doesn't have a really short half-life, it's approx. 2 days. For this reason, I doubt Cyanonilutamide has a short half-life either, it's probably around 1-2 days.

 

[Adri23]

You can get CB at approx. 30 USD per gram if you buy 10g or more. Running it at 50-60mg per day is a good starting point, no need to go higher than that immediately. But if you've set your mind to RU, then just start at a very low dose and hopefully, it should be fine.

But just FYI, RU is a prodrug of cyanonilutamide, i.e. when you apply RU to your scalp, a percentage of that will convert into cyanonilutamide and leak into the serum. Cyanonilutamide resembles nilutamide quite a lot. Nilutamide doesn't have a really short half-life, it's approx. 2 days. For this reason, I doubt Cyanonilutamide has a short half-life either, it's probably around 1-2 days.

How much would it cost if I buy 10g? CB is known to be pretty weak compared to RU. Do you think 2.5%-3% ru would be a good start?

 

[whitecoatblackhat]

How much would it cost if I buy 10g? CB is known to be pretty weak compared to RU.

Around 300USD. Yes, CB is weak compared to RU but it has a different pharmacokinetic profile since it's steroidal so it also diminishes the production of prostaglandin D2 and interleukin 6, regulates sebum secretion, and reduces dermal inflammation via a corticosteroid-like pathway.

It really depends on how aggressive your Androgenetic Alopecia is and how far gone you are.

You can try topical dutasteride mixed with 17a-estradiol (give it another shot). You can also try a higher dose of bimatoprost/latanoprost daily alongside wounding once a week plus LiCl, Methyl Ester of Vanillic Acid maybe even WAY316606 (I didn't see much if any results from it, also difficult to solubilise) or SM04554 (even though it was discarded). Look more into WNT, there are some really potent compounds out there that I won't mention because I don't want to promote them. Or you can look into more obscure compounds like TM30089. Maybe give topical Fevipiprant a shot.

Just spitballing ideas. Obviously, most of these compounds are lacklustre and controversial, and I'm sure someone will chip in to say that they are worthless. So do your own due diligence.

 

[Adri23]

Around 300USD. Yes, CB is weak compared to RU but it has a different pharmacokinetic profile since it's steroidal so it also diminishes the production of prostaglandin D2 and interleukin 6, regulates sebum secretion, and reduces dermal inflammation via a corticosteroid-like pathway.

It really depends on how aggressive your Androgenetic Alopecia is and how far gone you are.

You can try topical dutasteride mixed with 17a-estradiol (give it another shot). You can also try a higher dose of bimatoprost/latanoprost daily alongside wounding once a week plus LiCl, Methyl Ester of Vanillic Acid maybe even WAY316606 (I didn't see much if any results from it, also difficult to solubilise) or SM04554 (even though it was discarded). Look more into WNT, there are some really potent compounds out there that I won't mention because I don't want to promote them. Or you can look into more obscure compounds like TM30089. Maybe give topical Fevipiprant a shot.

Just spitballing ideas. Obviously, most of these compounds are lacklustre and controversial, and I'm sure someone will chip in to say that they are worthless. So do your own due diligence.

Man thats to complicated. I can't use dutasteride, it doesn't work for me even orally every day didn't drop my dht levels after 1.5 years of use. I don't use 17a estradiol because im using 17b estradiol instead. 300usd is to expensive man... Let's keep things simple, I will try ru and if it gives me side effect I'll try other stuff.

 

[whitecoatblackhat]

Man thats to complicated. I can't use dutasteride, it doesn't work for me even orally every day didn't drop my dht levels after 1.5 years of use. I don't use 17a estradiol because im using 17b estradiol instead. 300usd is to expensive man... Let's keep things simple, I will try ru and if it gives me side effect I'll try other stuff.

I see, that sucks. Yeah, you are definitely an outlier case if dutasteride didn't drop your DHT after 1.5 years. Maybe up the dose to 2.5mg of dutasteride a day. Or mix 0.5mg oral dutasteride plus topical dutasteride to spare your liver a bit (since topical bypasses 1st pass metabolism). Good luck pal

 

[Adri23]

I see, that sucks. Yeah, you are definitely an outlier case if dutasteride didn't drop your DHT after 1.5 years. Maybe up the dose to 2.5mg of dutasteride a day. Or mix 0.5mg oral dutasteride plus topical dutasteride to spare your liver a bit (since topical bypasses 1st pass metabolism). Good luck pal

It would spike my T levels to the sky. I already have 1011ng/dl T and 59ng/dl dht with 0.5 mg dutas. I've been told to stop dutas since it will do more harm than good for me. I'm using now topical finasteride + oral finasteride + e2 + oral minoxidil. Don't think this will work since I need a topica AA. My only salvation would be RU at this moment, till pyrilutamide gets released.

 

[whitecoatblackhat]

It would spike my T levels to the sky. I already have 1011ng/dl T and 59ng/dl dht with 0.5 mg dutas. I've been told to stop dutas since it will do more harm than good for me. I'm using now topical finasteride + oral finasteride + e2 + oral minoxidil. Don't think this will work since I need a topica AA. My only salvation would be RU at this moment, till pyrilutamide gets released.

You said you were using 17b-estradiol topically right? That should simmer down the scalp T since it upregulates aromatase expression (not as much as a strong AR antagonist though). That's why I suggested dutasteride. Yeah good luck with RU.

 

[SavingMyHair]

@GRme11 please open DM's, need to talk to you