Applying 17b Estradiol Without Systemic Absorption: Study Link

[hemingway_the_mercenary]

Low-Dose 17-β-Estradiol Cream for Vaginal Atrophy in a Cohort without Prolapse: Serum Levels and Vaginal Response Including Tissue Biomarkers Associated with Tissue Remodeling

Serum E2 levels (pg/mL) were unchanged from baseline (mean (SD)) 7.7 (3.3) to eight 9.7 (5.7) and sixteen 8.7 (5.8) (p=0.24) weeks. VMI (mean (SD)) improved from baseline 34.2 (18.3) to eight 56.7 (13.1) and sixteen 54.5 (11.3) (p<0.001) weeks with no difference between eight and sixteen weeks. Vaginal dryness (p=0.03) and itching (p=0.02) improved. Tissue biomarker levels did not change (TGF-β p=0.35, NFKB p=0.74, eNOS p=0.80, iNOS p=0.24, TSP p=0.80).

17b estradiol is very important for vaginal health for women as they age however due to the fear of developing breast cancer, many women choose to not use estradiol. This study assesed the effectiveness of estradiol creat at revitilizing the vaginal athrophy while also measuring serum estradiol levels. They found that serum estradiol levels did not increase

This means that it is possible to use 17b estradiol topically with minimal or no systemic absorption.
For those of us who believe that estrogen is a key factor in hair regrowth/maintenance, this is huge. I will be trying to get a hold of this estrogen cream they used in the study.

If anyone is interested in trying this out I recommend having a drug like Nolvadex or Raloxifene on hand just in case you get symptoms of gyno, you can stop the estrogen and use nolvadex for a few days and you'll be fine

@whatevr @JLF @all the crazy mfers on this forum who are willing to try anythng

 

[Jesse Navarro]

How much would you apply? You intend to apply it on the scalp?

 

[hemingway_the_mercenary]

How much would you apply? You intend to apply it on the scalp?

You would apply as much as 1gram of the cream per day on the scalp. That is the max dosage which was tested on this study to not raise serum levels and was also effective at healing the vaginal walls (this means that it will be more than enough for you follicles

I would recommend to start at 0.5g of the cream which would be 50 micrograms of estradiol, then up it to 1g if you dont get any side effects

 

[Grasshüpfer]

This would be huge. Keep us updated!

 

[DiffThinner35]

Yeah, but what if you grow a vagina on your head?

 

[Jesse Navarro]

You would apply as much as 1gram of the cream per day on the scalp. That is the max dosage which was tested on this study to not raise serum levels and was also effective at healing the vaginal walls (this means that it will be more than enough for you follicles

I would recommend to start at 0.5g of the cream which would be 50 micrograms of estradiol, then up it to 1g if you dont get any side effects

That would be one application, which usually contains 0,5 mg of estriol.

 

[Jesse Navarro]

Yeah, but what if you grow a vagina on your head?

At least it would be a moisturized vagina.

 

[Let there be follicles!]

You cannot apply topical without systemic absorption. I know hairlosstalk scientists may not like this but it’s cold hard facts.

 

[hemingway_the_mercenary]

You cannot apply topical without systemic absorption. I know hairlosstalk scientists may not like this but it’s cold hard facts.

Actually you are the hairlosstalk scientist. I posted a scientific study domonstrating that you can apply a topical without raising serum levels

 

[Let there be follicles!]

Actually you are the hairlosstalk scientist. I posted a scientific study domonstrating that you can apply a topical without raising serum levels

Open a book and learn what lies under the layer of skin you see. It is impossible because you want something to be absorbed right under the skin but not enough to be absorbed systemically. It’s impossible and so are those ridiculous monkey studies you kids post regularly. This ncbi meme frenzy needs to stop at some point.

 

[Murkey Thumb]

To be honest I very much doubt that there will be no systemic absorption. The creams are used by transitional male to female gender re-assigner's on their skin so it is meant to be absorbed through the skin. Maybe small amounts are tolerable but it will go systemic.

 

[Jesse Navarro]

Maybe a very low dosage (say, just enough to apply on your scalp two times a day) would not give side effects and would counteract the rise on testosterone given by dutasteride?

 

[Murkey Thumb]

Maybe a very low dosage (say, just enough to apply on your scalp two times a day) would not give side effects and would counteract the rise on testosterone given by dutasteride?

Not sure you would need dutasteride if 17b estradiol is dominant in your scalp.

 

[hemingway_the_mercenary]

Maybe a very low dosage (say, just enough to apply on your scalp two times a day) would not give side effects and would counteract the rise on testosterone given by dutasteride?

if the dosage in the study was enough to hypertrophy the vaginal walls then it will be enough to have an effect on male pattern baldness, obv you cant use it by itself

Open a book and learn what lies under the layer of skin you see. It is impossible because you want something to be absorbed right under the skin but not enough to be absorbed systemically. It’s impossible and so are those ridiculous monkey studies you kids post regularly. This ncbi meme frenzy needs to stop at some point.

how about you open your eyes and read the study, your opinion means nothing

To be honest I very much doubt that there will be no systemic absorption. The creams are used by transitional male to female gender re-assigner's on their skin so it is meant to be absorbed through the skin. Maybe small amounts are tolerable but it will go systemic.

this isnt the cream made for transgenders, this is for vaginal atrophy

 

[Let there be follicles!]

if the dosage in the study was enough to hypertrophy the vaginal walls then it will be enough to have an effect on male pattern baldness, obv you cant use it by itself


how about you open your eyes and read the study, your opinion means nothing



this isnt the cream made for transgenders, this is for vaginal atrophy

What study you f*****g monkey... don’t you get that half the sh*t you idiots shill on ncbi are just dumb experiments that end their report with “probably”, “perhaps” and “no substantial difference”? Do you have any idea how many “studies” like those are done in universities in my country alone? Open a f*****g book, read what lies underneath your skin layers. You want to put a cream in your skin and it has to go under it and stay there and somehow enter certain areas without entering others such as a vast network of blood vessels which btw are EVERYWHERE and absorb as sponges. You kids had the same debate over his topical finasteride sh*t. Why do you think Merck didn’t do it ten years ago? Because it’s so f*****g stupid that even if the entire process was to be free, they still wouldn’t. “Open your eyes” lmao for f*** sake you people are mentally ill. No wonder nobody gives a f*** about AA. You do realize both minoxidil and antiandrogens were made for something else and not AA? Nobody cares. You kids think people will spend decades to do what? Fix your ego by putting some hair on your head? They search organ development and other important sh*t. The next true cure for hair will be accidental again. If you see something being developed from scratch for hair loss, move on.

 

[hemingway_the_mercenary]

What study you f*****g monkey... don’t you get that half the sh*t you idiots shill on ncbi are just dumb experiments that end their report with “probably”, “perhaps” and “no substantial difference”? Do you have any idea how many “studies” like those are done in universities in my country alone? Open a f*****g book, read what lies underneath your skin layers. You want to put a cream in your skin and it has to go under it and stay there and somehow enter certain areas without entering others such as a vast network of blood vessels which btw are EVERYWHERE and absorb as sponges. You kids had the same debate over his topical finasteride sh*t. Why do you think Merck didn’t do it ten years ago? Because it’s so f*****g stupid that even if the entire process was to be free, they still wouldn’t. “Open your eyes” lmao for f*** sake you people are mentally ill. No wonder nobody gives a f*** about AA. You do realize both minoxidil and antiandrogens were made for something else and not AA? Nobody cares. You kids think people will spend decades to do what? Fix your ego by putting some hair on your head? They search organ development and other important sh*t. The next true cure for hair will be accidental again. If you see something being developed from scratch for hair loss, move on.

cool, leave this thread now you ignorant idiot

 

[Let there be follicles!]

cool, leave this thread now you ignorant idiot

Every time someone shuts you kids up, you put up a flag and cry “leeve”.

 

[Ein]

Well, the study that you are referring to says that serum estradiol levels were unaltered, but it didn't say anything about levels of leutenizing hormone or systemic absorption. There is a good possibility that it was absorbed, raised the levels, affected the leutenizing hormone levels by getting detected in the hypothalamus, and eventually lowered the body's own production of estradiol. But of course, that's only my own hypothesis.

 

[Murkey Thumb]

Side effects of Estrace low dose vaginal estradiol cream :The most common side effects include: headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and/or bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, vaginal burning, irritation and itching. Hair Loss?!!

 

[Ein]

Side effects of Estrace low dose vaginal estradiol cream :The most common side effects include: headache, breast pain, irregular vaginal bleeding or spotting, stomach/abdominal cramps and/or bloating, nausea and vomiting, hair loss, fluid retention, vaginal yeast infection, vaginal burning, irritation and itching. Hair Loss?!!

There's this popular theory about estrogen dominance.
https://en.m.wikipedia.org/wiki/Estrogen_dominancedominance
It states that too much estrogen without progesterone can cause hair loss too.