Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[FilthyFrancis]

So what Are the Next steps?
The Homepage of hopemedinc is offline.
No announcements since December 2020

They should Start the trial soon But no infos unforntinately

HopeMedicine | Distance Healing | Energy Medicine | Holistic Medicine

HopeMedicine is based on the energy of thousands of plants and natural products, and an advanced distance healing system to send it to patients around the world

hopemedicine.org

Here they are! They actually pivoted to another strategy: distant healing

 

[RolfLeeBuckler]

HopeMedicine | Distance Healing | Energy Medicine | Holistic Medicine

HopeMedicine is based on the energy of thousands of plants and natural products, and an advanced distance healing system to send it to patients around the world

hopemedicine.org

Here they are! They actually pivoted to another strategy: distant healing

WRONG! your link is of a company from Pakistan which hasnt any connection to HopeMedicine of China.

As you can see the chines HopeMedicine has another homepage with is offline unfortunately:

About​

Hope Medicine is a science-driven clinical stage biopharmaceutical company

• Nanjing, Jiangsu, China
• 1-10
• Series A
• Private
• hopemedinc.com/

 

[FilthyFrancis]

WRONG! your link is of a company from Pakistan which hasnt any connection to HopeMedicine of China.

As you can see the chines HopeMedicine has another homepage with is offline unfortunately:

About​

Hope Medicine is a science-driven clinical stage biopharmaceutical company

• Nanjing, Jiangsu, China
• 1-10
• Series A
• Private
• hopemedinc.com/

Oh my bad, thanks for warning me.

Just when I was about to share my bank details with their seemingly trustworthy doctor, Dastageer Fambarzahi, who's kindly been trying to cure my hair loss remotely on the phone for the last 2 hours.

 

[Ollie]

Oh my bad, thanks for warning me.

Just when I was about to share my bank details with their seemingly trustworthy doctor, Dastageer Fambarzahi, who's kindly been trying to cure my hair loss remotely on the phone for the last 2 hours.

Just imagine if he managed it

 

[elevic]

It makes sense. They have very high prolactin levels for the first 6+ weeks after birth

When I first grew hair as a new born I had exactly the same Norwood pattern that I have now. And there are studies that suggest that prolactin might be linked to the characteristic Androgenetic Alopecia pattern. In my ignorance, everything seems to add up. Could prolactin be the cause of my pattern as a baby?

 

[-specter-]

we hope it is the definitive turning point for hair regrowth. I started losing them when I was 23

 

[JaneyElizabeth]

The pattern is likely due to the highest points of scalp and forehead tension. For all children among caucasians, hair fills in last in the temples which is where males lose it first, along with the crown. And of course, it is not the definitive turning point for hair growth. No male meds grow hair sadly nor are they likely to until 2041 when the third round of trials begin for Rogrow-Again. Keep your eyes on that one.

 

[czecha]

When I first grew hair as a new born I had exactly the same Norwood pattern that I have now. And there are studies that suggest that prolactin might be linked to the characteristic Androgenetic Alopecia pattern. In my ignorance, everything seems to add up. Could prolactin be the cause of my pattern as a baby?

elevated cortisol of the mother during pregnancy is reflected in neonates hair
elevated cortisol of the mother also delays their milk production, so probably lowers their prolactin

Would be interesting to see if mothers with psychological problems during the pregnancy get balder kids

The pattern is likely due to the highest points of scalp and forehead tension. For all children among caucasians, hair fills in last in the temples which is where males lose it first, along with the crown. And of course, it is not the definitive turning point for hair growth. No male meds grow hair sadly nor are they likely to until 2041 when the third round of trials begin for Rogrow-Again. Keep your eyes on that one.

i‘d have to agree with you on that, although it’s unclear and probably case dependent how hormones, skull expansion, tension and metabolism/blood flow are interdependent. I think a bad hormonal profile leads to male pattern baldness by itself, but could also expands your skull for example, which restricts blood flow combined with lower metabolism after your teens, which induces hypoxia, which affects test metabolism in that hormones are less likely to be oxidized into hair friendly hormones and more likely to be 5ar degraded. So it’s not „less bloodflow less nutrients“, it’s less bloodflow altered local hormones.

I think a strong metabolism protects against scalp tension/ bloodflow problems and can overcome scalp expansion to a certain degree. A strong teenage like metabolism can also be „faked“ with I think two drugs: minoxidil (which also works in other ways) and caffeine. Basically things that make your heart beat stronger which gets blood in your scalp. This should delay local hypoxia and fibrosis.
Caffeine I think has to be megadosed to achieve that though, upwards of 800mg/ day, and won’t regrow hair or adress more holistic hormonal characteristics that would cause male pattern baldness. I have no idea if bloodflow/ scalp expansion/tension/metabolism is 5% or 50% of male pattern baldness, but after having run minoxidil and high dose caffeine and the way it affects my scalp I’m certain it plays a role (in my case)


Children with expanded foreheads have the least hair in the front. Even young girls with giga expanded foreheads are nw2-3

it’s totally possible that a theory is correct without it being the biggest contributor to male pattern baldness

 

[pegasus2]

When I first grew hair as a new born I had exactly the same Norwood pattern that I have now. And there are studies that suggest that prolactin might be linked to the characteristic Androgenetic Alopecia pattern. In my ignorance, everything seems to add up. Could prolactin be the cause of my pattern as a baby?

It's really hard to say because we don't know the levels of autocrine/paracrine prolactin in any part of the scalp. We have a couple hints that it is involved in the pattern, but newborns have supraphysiological levels of serum prolactin so their scalp should thin/bald everywhere they have prolactin receptors.

Scalp tension has been debunked for 60 years over and over. None of the top hair loss researchers believe in that, only some amateur researchers that publish their nonsense in low impact journals. I'm not going to derail this with that nonsense but you can search the forum for that.

There is indeed tons of evidence implying that prolactin is the missing link or one of them. Prolactin may be involved in downregulating Wnt signaling in the HF which is the cause of hair loss.

 

[JaneyElizabeth]

elevated cortisol of the mother during pregnancy is reflected in neonates hair
elevated cortisol of the mother also delays their milk production, so probably lowers their prolactin

Would be interesting to see if mothers with psychological problems during the pregnancy get balder kids





i‘d have to agree with you on that, although it’s unclear and probably case dependent how hormones, skull expansion, tension and metabolism/blood flow are interdependent. I think a bad hormonal profile leads to male pattern baldness by itself, but could also expands your skull for example, which restricts blood flow combined with lower metabolism after your teens, which induces hypoxia, which affects test metabolism in that hormones are less likely to be oxidized into hair friendly hormones and more likely to be 5ar degraded. So it’s not „less bloodflow less nutrients“, it’s less bloodflow altered local hormones.

I think a strong metabolism protects against scalp tension/ bloodflow problems and can overcome scalp expansion to a certain degree. A strong teenage like metabolism can also be „faked“ with I think two drugs: minoxidil (which also works in other ways) and caffeine. Basically things that make your heart beat stronger which gets blood in your scalp. This should delay local hypoxia and fibrosis.
Caffeine I think has to be megadosed to achieve that though, upwards of 800mg/ day, and won’t regrow hair or adress more holistic hormonal characteristics that would cause male pattern baldness. I have no idea if bloodflow/ scalp expansion/tension/metabolism is 5% or 50% of male pattern baldness, but after having run minoxidil and high dose caffeine and the way it affects my scalp I’m certain it plays a role (in my case)


Children with expanded foreheads have the least hair in the front. Even young girls with giga expanded foreheads are nw2-3

it’s totally possible that a theory is correct without it being the biggest contributor to male pattern baldness

You write copiously like me. I think that sounds right. But so much is possible with the indicated theory. Miracles can come true if we want it enough:

https://www.hairlosstalk.com/interact/threads/hair-is-not-life-but-its-pretty-damn-close-hrt-and-pictorial-posts-prove-it.130425/page-49

 

[czecha]

You write copiously like me. I think that sounds right. But so much is possible with the indicated theory. Miracles can come true if we want it enough:

https://www.hairlosstalk.com/interact/threads/hair-is-not-life-but-its-pretty-damn-close-hrt-and-pictorial-posts-prove-it.130425/page-49

I think worth exploring is male pattern baldness in hyperthyroid men, because they have a high heart rate which is what caffeine/minoxidil emulate

from what i can tell they still go bald, but rarely/never (?) recede

thats their heart rate offsetting hypoxia in their temples i am betting

no idea why they would diffuse though ngl

 

[Carbons]

I think worth exploring is male pattern baldness in hyperthyroid men, because they have a high heart rate which is what caffeine/minoxidil emulate

from what i can tell they still go bald, but rarely/never (?) recede

thats their heart rate offsetting hypoxia in their temples i am betting

no idea why they would diffuse though ngl

Have mild hyperthyroidism from my father's side, have diffuse thinning matching my father and temple recession matching my mother's father. One sibling just has temple recession, other has diffuse. Seems 99% genetic to me.

 

[Jesse14]

It's really hard to say because we don't know the levels of autocrine/paracrine prolactin in any part of the scalp. We have a couple hints that it is involved in the pattern, but newborns have supraphysiological levels of serum prolactin so their scalp should thin/bald everywhere they have prolactin receptors.

Scalp tension has been debunked for 60 years over and over. None of the top hair loss researchers believe in that, only some amateur researchers that publish their nonsense in low impact journals. I'm not going to derail this with that nonsense but you can search the forum for that.

There is indeed tons of evidence implying that prolactin is the missing link or one of them. Prolactin may be involved in downregulating Wnt signaling in the HF which is the cause of hair loss.

Interesting to see this now. I ordered some cabergoline the other day.

 

[FollicleGuardian]

Interesting to see this now. I ordered some cabergoline the other day.

Won’t do anything for your hair. You need to tackle extrapituitary prolactin through the PRLR.

 

[Selb]

Won’t do anything for your hair. You need to tackle extrapituitary prolactin through the PRLR.

I wonder if you can use it topically to silence extra prolactin. I assume the reason why systemic dopamine agonists don’t work like BAY because the scalp’s main source of prolactin comes from tissue generation like from the pituitary gland. And even long half life dopamine agonists won’t silence prolactin completely in the scalp. But topically applying it might provide enough of it to suppress it directly in the tissue.

 

[FollicleGuardian]

I wonder if you can use it topically to silence extra prolactin. I assume the reason why systemic dopamine agonists don’t work like BAY because the scalp’s main source of prolactin comes from tissue generation like from the pituitary gland. And even long half life dopamine agonists won’t silence prolactin completely in the scalp. But topically applying it might provide enough of it to suppress it directly in the tissue.

Unfortunately will not work.. Dopamine agonists do not affect the local prolactin production. Only the pituitary gland..

 

[Kagaho]

The more I delve into the patent, the more expectation it generates me.

What this thing did to the monkeys was extraordinary.

Hopefully it is replicable in humans, even if it is not at such an extreme level of recovery it would be superior to everything we have now.

 

[FollicleGuardian]

Let's hope SMI will be enough but I'm not sure as pegasus already stated before:


There is SMI-1 and SMI-6 that @FollicleGuardian found for a cheap price. It's not the same though. Per the patent, competitive antagonists of the receptor are ineffective in the hair follicle because concentrations of prolactin are too high since it's produced within the hair follicle, and prolactin has a higher binding affinity for the receptor than the antagonists.




This might be why the small molecule antagonists don't include hair loss as a potential indication in the patent.

The antibody is a non-competitive inhibitor, meaning that it doesn't have to outcompete prolactin for receptor binding. It can bind to the receptor along with prolactin and still silence it.

I think the competitive antagonists are likely better than nothing, but they won't give the kind of regrowth the antibody does

Per the BAY patent:

competitive PRLR antagonists are not effective in neutralizing local PRL signaling in the hair follicle due to their negative characteristics which are

1) a reduced PRLR inhibition in the presence of increasing PRL concentrations due to the competitive mechanism of action
2) reduced half-life
3) reduced affinity to the PRLR if compared to PRL.

SMI has already solved no 2. It also has very strong affinity to the PRL receptor. Kd= 3.3. It remains to be seen if it is enough to solve 1, and 3.

 

[FollicleGuardian]

SMI is for breast cancer, and in breast cancer tissues iirc the PRL concentration is 17.6x normal tissues. So it should in theory be very potent. If not it will never work for breast cancer. And consequenses much worse than balding ofc.

 

[czecha]

SMI is for breast cancer, and in breast cancer tissues iirc the PRL concentration is 17.6x normal tissues. So it should in theory be very potent. If not it will never work for breast cancer. And consequenses much worse than balding ofc.

Cope