Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

[thomps1523]

What if that isn't needed though? They might not be dosing for 12 months straight, just using the reference period to measure safety/results. Also, isn't there theoretically a ceiling on the benefit that any person could get from this? If you have follicles that are calcified/scarred over then even this isn't brining them back.

In instances like this what would prevent vellus hairs grown through derma rolling from benefiting and helping someone get back to a full head?

I know this has been asked but I didn’t really notice how it was addressed... Still too many unknowns to know I’m sure.

 

[pegasus2]

What if that isn't needed though? They might not be dosing for 12 months straight, just using the reference period to measure safety/results. Also, isn't there theoretically a ceiling on the benefit that any person could get from this? If you have follicles that are calcified/scarred over then even this isn't brining them back.

Six months isn't maximum results. At some point it has to level off, but there is no leveling off of the trend in this six month chart. The top two responders appear to be on their way to full density in one year. The rest either need more time or just can't achieve full density. It takes a long time for the follicle to be completely destroyed by fibrosis.

 

[MrJolly26]

Bayer is a top dog company, I don´t still believe it! So eager to learn more about this product.

 

[trialAcc]

Min is 1500 a dose as they can charge it, they could sell it for <1000 providing its produced on a large enough scale and the demand is high and still keep good margins.

Keep in mind, this isn't just being used/trialled for Androgenetic Alopecia. It's also going through trials for Endo, and possibly other indications in the future.

This is far from my realm of knowledge, but I'd imagine id would be advantageous to sell it for Androgenetic Alopecia (not covered by insurance) at a somewhat reduced price. It would be more cost efficient to produce a larger amount consistently, and sell part of it at a reduced price - surely? This is just pure speculation on my part though.

Would like to hear your view on this though, and whether them producing the same mAb for other conditions could make a price reduction for non-insurance covered conditions feasible.

Thanks

No what you said is correct, they will legitimately have to price is more reasonably or they would be charging around that average 100k mark I posted earlier. That's why I always roll my eyes when I see people talking about how much money is in hairloss treatments. When you remove insurance from the equation, most of the profit incentive for the drug companies goes away.

This drug could restore perfect hair, but at 100k/yr price tag out of pocket almost no one would use it.

 

[Ollie]

This surely has to be the new v**** for older men. Nothing kills wood more than prolactin - which sores with age thanks to rising estrogen in relation to T

 

[jan_miezda]

This surely has to be the new v**** for older men. Nothing kills wood more than prolactin - which sores with age thanks to rising estrogen in relation to T

Kevin Mann after phase 2 results : Prolactin is a trash garbage hormone

 

[Derelict]

Potentially far too expensive for me right now, but very interesting.

 

[-specter-]

I think they will lower the price to maximize the profit, it makes no sense to slow down sales with a high price. At most it could cost more at the time of launch on the market and then drop shortly after.

 

[RolfLeeBuckler]

I am sorry, have to ask this Again because i didn‘t get it:

Does HMI-115 will give the patient a HIGH prolactin-Level or a LOW prolactin-Level?

 

[Ollie]

I am sorry, have to ask this Again because i didn‘t get it:

Does HMI-115 will give the patient a HIGH prolactin-Level or a LOW prolactin-Level?

The antibody prevents PRL signalling. So prolactin will either stay the same but just remain ineffective or like with other receptor inhibiting drugs the feedback loop may lead to a slight upregulation of prolactin - but still remain ineffective.

 

[FollicleGuardian]

Serum levels will increase somewhat like in the LFA antibody clinical trial, but @Ollie is right. It will remain ineffective.

 

[poopfeast420]

Have you guys started applying SMI-6?

 

[resu]

2 times per month dosing of 30-90 mg. So we could expect the treatment to cost 10-12.000 $? (6 months).

Would rather go to Dr Diep and do an FUE for that price.

 

[trialAcc]

Would rather go to Dr Diep and do an FUE for that price.

Surgery and 30% density? Who wouldn't prefer that to natural follicles growing back?

 

[FollicleGuardian]

Surgery and 30% density? Who wouldn't prefer that to natural follicles growing back?

30% density?

 

[trialAcc]

He still thinks FUE surgery is sh*t probably. Of course it's not, we're not in the 90's anymore.

You think you get more then 30% density on average for hair transplants NW4+? The math doesn't make any sense.

 

[trialAcc]

30% density?

Yeah like if you were NW4+ and get a full FUE restoration. The density throughout your transplanted zones is not going to be more then 30%~ what you would naturally have over that entire area. Sure, they might go 50%+ in the hairline for maximum appearance, but overall you're not averaging more then 30-35% throughout, especially for NW5+.

 

[pegasus2]

Would rather go to Dr Diep and do an FUE for that price.

Let's do the math. 300cm² in a norwood 7 area. The top responder gained 250 hairs/cm². That's 75,000 hairs. Dr. Diep charges about $12 per graft, with each graft averaging about 2.1 hairs. To get 75,000 hairs you'd need 35,714 grafts. If you had that many grafts available that's $428,000, and your back and sides would be bald. Now which one is the better deal?

 

[Chads don't bald]

Still though, 10k every 6 months is a lot. That's 20k a year to maintain your hair lol

Better than nothing though for sure

 

[pegasus2]

Still though, 10k every 6 months is a lot. That's 20k a year to maintain your hair lol

Better than nothing though for sure

You only need it until you're done regrowing. The monkeys were on it for 6 months and maintained some degree of effect for 4 years and counting. Maybe a 6 month cycle every few years would be required to maintain.