Bayer Prolactin Receptor Antibody For Male And Female Pattern Hair Loss

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trialAcc

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pegasus2 said:
I already told you guys not to expect it to reverse slick bald areas. We can very effectively create vellus hair with follica's protocol, making the combination a total solution
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The question is can it take those vellus hairs and make them terminal, or will it be more like finasteride where you can save some hairs that are not below a certain miniaturization threshold. If not, add this to the list of thing's that will mostly help the next generation.

The impressive part to me is how long the results lasted though. It seems like the quicker we get on this, the more likely we will never have to deal with hairloss progression.
 
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scientist_0005

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trialAcc said:
The question is can it take those vellus hairs and make them terminal, or will it be more like finasteride where you can save some hairs that are not below a certain miniaturization threshold. If not, add this to the list of thing's that will mostly help the next generation.
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i thibk the study answers that?
 
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trialAcc

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scientist_0005 said:
i thibk the study answers that?
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Yes on monkeys. Doesn't mean it translates 1:1. I also swear that these monkey's dont go "bald" like humans do, so when the study references bald areas it means areas with a density under a certain number.
 
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Sorry if this has been answered (and sorry if I've already asked this - I'm dumb), but when are results from the next phase of clinical trials expected?
 
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Dimitri001

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pegasus2 said:
She. It was in Chinese media. I don't have the link. She basically said they founded HMI because of the hair growth in macaques. The other indications for the drug are just a bonus.
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I thought the story was that the primary indication was endometriosis and that's what they were testing HMI for in the monkeys when they accidentally found the hair regrowth effect, no?
 
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pegasus2

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Dimitri001 said:
I thought the story was that the primary indication was endometriosis and that's what they were testing HMI for in the monkeys when they accidentally found the hair regrowth effect, no?
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No. Bayer developed the drug for endo. They tested it in mice and found out accidentally that it grew hair. Rui-Ping Xiao was working with Bayer and convinced them to let her try it on her monkeys for hair loss. They agreed, and after it successfully grew hair in the monkeys she founded HMI to purchase the rights to market the drug. Bayer was only interested in endo and breast cancer because they are focused on treating women's health issues, but HMI was more interested in Androgenetic Alopecia because that's where the drug showed the most promise.
 
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coolio

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Bayer was only interested in endo and breast cancer because they are focused on treating women's health issues, but HMI was more interested in Androgenetic Alopecia because that's where the drug showed the most promise.
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. . . . and when the first effective androgenic hair loss treatment finally comes out, the industry will be surprised by how many women line up to pay for it.
 
LouisSarkozy

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pegasus2 said:
No. Bayer developed the drug for endo. They tested it in mice and found out accidentally that it grew hair. Rui-Ping Xiao was working with Bayer and convinced them to let her try it on her monkeys for hair loss. They agreed, and after it successfully grew hair in the monkeys she founded HMI to purchase the rights to market the drug. Bayer was only interested in endo and breast cancer because they are focused on treating women's health issues, but HMI was more interested in Androgenetic Alopecia because that's where the drug showed the most promise.
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man sorry to ask that but for slick bald area would follica protocol to grow vellus then using bay to turn them terminal would basically be a cure? thanks you very much

i mean would bay be powerfull enough to turn follica vellus into something cosmetic enough to be perceive as a terminal hair ? sorry again
 
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pegasus2 said:
No. Bayer developed the drug for endo. They tested it in mice and found out accidentally that it grew hair. Rui-Ping Xiao was working with Bayer and convinced them to let her try it on her monkeys for hair loss. They agreed, and after it successfully grew hair in the monkeys she founded HMI to purchase the rights to market the drug. Bayer was only interested in endo and breast cancer because they are focused on treating women's health issues, but HMI was more interested in Androgenetic Alopecia because that's where the drug showed the most promise.
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So we're all gonna end up owing our hair to a Chinese lady. We should send her a bouquet of roses if this thing comes through.
 
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LouisSarkozy said:
man sorry to ask that but for slick bald area would follica protocol to grow vellus then using bay to turn them terminal would basically be a cure? thanks you very much

i mean would bay be powerfull enough to turn follica vellus into something cosmetic enough to be perceive as a terminal hair ? sorry again
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He's not going to be able to give you a definitive answer, but the study would suggest that it could based on the results observed in pre-clinical. The monkey's were declared to have significant growth on "bald" areas, which for them is vellus heavy.
 
LouisSarkozy

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trialAcc said:
He's not going to be able to give you a definitive answer, but the study would suggest that it could based on the results observed in pre-clinical. The monkey's were declared to have significant growth on "bald" areas, which for them is vellus heavy.
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thanks for trying to give me an answer i'm sorry but ican't take it anymore and i have vellus down to now0 area thanks to minoxidil but tey are not growing at all... do you think it's a wise plan to keep using the minoxidil to maintain those vellus and avoid fibrosi till we get our hands on bay in 2025 theoriclly? thanks
 
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Just the day before yesterday I sent an email to Professor Xiao Ruiping to ask some questions, the main content of the email is as follows.
Hello Professor Xiao.
I am a researcher, and I especially admire your academic research. I would like to ask you some questions about your team's research, and I would appreciate your advice.
(1) Your team conducted an experimental study on monoclonal antibodies to the prolactin receptor in red-faced monkeys in 2016, but why is there no published academic research paper?
(2) According to the data and information you have so far, is the prolactin receptor monoclonal antibody effective in treating the red-faced monkey hair loss model? Is it possible to transfer to human clinical trials?
(3) We have already started a clinical study abroad, is this clinical study mainly for endometriosis or also for androgenetic alopecia?
I did not expect Prof. Xiao Ruiping to reply to my email, but to my surprise, I received a reply from her today.
Thank you for your interest in my research. The red-faced monkey results are exciting, and we are currently applying for human trials. I hope to have good news to share with you in the near future.
Best wishes.
Rui-Ping Xiao
Although the reply letter is very concise, I am very happy to receive her reply.
In fact, I retrieved a patent application from Bayer a few days ago: Prolactin receptor monoclonal antibody for the treatment of male and female androgenic alopecia. This is an international patent, but I am in China, so I can't view it, let alone download it.
The title of this patent is: PROLACTIN RECEPTOR ANTIBODY FOR MALE AND FEMALE PATTERN HAIR LOSS (prolactin receptor antibody for male and female androgenic alopecia)
International Patent No.: WO 2019/011719 Al
This patent was filed by Bayer in Germany back in 2018 and the application was successful in 2019. This patent describes the results of the study in that picture shown by Prof. Rui-Ping Xiao's research team, and the original part of the patent involving the red-faced monkey test reads
A very high proportion (81%) of animals (9 out of 11) responded to compound treatment, although the population was heterogeneous with respect to age and A very high proportion (81%) of animals (9 out of 11) responded to compound treatment, although the population was heterogeneous with respect to age and gender and the observed area showed long-term baldness before treatment. 5 out of 1 1 monkeys were >25 years of age and were considered particularly However, three of those responded to compound treatment. Notably, completely bald scalp areas responded best. mat3 showed more efficacy and was effective following a more convenient regime (s.c. twice per month) than the only two approved medications for M/FPHL ( minoxidil (topical, daily), and finasteride (oral, once daily, men only).
Eighty-one percent (9 of 11) of the animals (red-faced monkeys) responded to treatment with antibodies to the prolactin receptors, although the monkeys varied in age and sex, and some of these monkeys had been balding for a long time before treatment.1 Five of the 1 monkeys were older than 25 years, and their male pattern baldness was very difficult to treat. However, three of these five responded to treatment. Of note: the scalp area with complete baldness responded best. Prolactin receptor antibody mat3 showed higher efficiency and better efficacy with a more convenient regimen (twice monthly subcutaneous injections) compared to the only two approved drugs (minoxidil (topical, once daily) and finasteride (oral, once daily, men only).
That's why I said when I saw that picture posted by Prof. Shaw: this is the best treatment effect published by the lab so far. Not only in the fact that it makes hair grow back in bald areas, but also in the fact that it continues to work well several years after stopping the drug, and that its treatment regimen requires only two subcutaneous injections per month. In all these aspects it crushes the treatment effects of finasteride and minoxidil.
After I wrote the article "The best lab results chart for androgenic alopecia treatment ever seen by mankind", some people on the internet said that it was not the best results chart ever seen by mankind. I am of course talking about the overall results and not just the significance of a picture, otherwise it is nowhere near as good as the results chart given by those who sell pure herbal shampoos on the internet. However, I'm not going to defend myself at all. I said in my article "I don't make any arguments about hair loss (talk about comparable fall and Panga's Crossing)" that if any of the views in my previous articles contradict the views of others on the web, everything is subject to the views of others on the web, and in any case, you can just take the views of others without any need to seek my consent.
I am not averse to thoughtful arguments, and I hope that more and more people will really pay attention to the topic of hair loss and the industry, provided that they really pay attention, and not to use, amuse and consume this topic for the sake of profit, which will only make this topic more distorted and skewed.
Finally, I would like to thank Professor Xiao Ruiping for his reply and look forward to hearing your good news soon.
Previous Review.

More on Prof. Ruiping Xiao and the monoclonal antibody to the prolactin receptor

The best ever laboratory results of androgenetic alopecia treatment in human history

The basic facts about PRP mesodermal injections

The truth about the progress of new drug development for hair loss

Some recent thoughts and summaries on hair loss

Translated with www.DeepL.com/Translator (free version)
 
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jan_miezda

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scientist_0005 said:
Just the day before yesterday I sent an email to Professor Xiao Ruiping to ask some questions, the main content of the email is as follows.
Hello Professor Xiao.
I am a researcher, and I especially admire your academic research. I would like to ask you some questions about your team's research, and I would appreciate your advice.
(1) Your team conducted an experimental study on monoclonal antibodies to the prolactin receptor in red-faced monkeys in 2016, but why is there no published academic research paper?
(2) According to the data and information you have so far, is the prolactin receptor monoclonal antibody effective in treating the red-faced monkey hair loss model? Is it possible to transfer to human clinical trials?
(3) We have already started a clinical study abroad, is this clinical study mainly for endometriosis or also for androgenetic alopecia?
I did not expect Prof. Xiao Ruiping to reply to my email, but to my surprise, I received a reply from her today.
Thank you for your interest in my research. The red-faced monkey results are exciting, and we are currently applying for human trials. I hope to have good news to share with you in the near future.
Best wishes.
Rui-Ping Xiao
Although the reply letter is very concise, I am very happy to receive her reply.
In fact, I retrieved a patent application from Bayer a few days ago: Prolactin receptor monoclonal antibody for the treatment of male and female androgenic alopecia. This is an international patent, but I am in China, so I can't view it, let alone download it.
The title of this patent is: PROLACTIN RECEPTOR ANTIBODY FOR MALE AND FEMALE PATTERN HAIR LOSS (prolactin receptor antibody for male and female androgenic alopecia)
International Patent No.: WO 2019/011719 Al
This patent was filed by Bayer in Germany back in 2018 and the application was successful in 2019. This patent describes the results of the study in that picture shown by Prof. Rui-Ping Xiao's research team, and the original part of the patent involving the red-faced monkey test reads
A very high proportion (81%) of animals (9 out of 11) responded to compound treatment, although the population was heterogeneous with respect to age and A very high proportion (81%) of animals (9 out of 11) responded to compound treatment, although the population was heterogeneous with respect to age and gender and the observed area showed long-term baldness before treatment. 5 out of 1 1 monkeys were >25 years of age and were considered particularly However, three of those responded to compound treatment. Notably, completely bald scalp areas responded best. mat3 showed more efficacy and was effective following a more convenient regime (s.c. twice per month) than the only two approved medications for M/FPHL ( minoxidil (topical, daily), and finasteride (oral, once daily, men only).
Eighty-one percent (9 of 11) of the animals (red-faced monkeys) responded to treatment with antibodies to the prolactin receptors, although the monkeys varied in age and sex, and some of these monkeys had been balding for a long time before treatment.1 Five of the 1 monkeys were older than 25 years, and their male pattern baldness was very difficult to treat. However, three of these five responded to treatment. Of note: the scalp area with complete baldness responded best. Prolactin receptor antibody mat3 showed higher efficiency and better efficacy with a more convenient regimen (twice monthly subcutaneous injections) compared to the only two approved drugs (minoxidil (topical, once daily) and finasteride (oral, once daily, men only).
That's why I said when I saw that picture posted by Prof. Shaw: this is the best treatment effect published by the lab so far. Not only in the fact that it makes hair grow back in bald areas, but also in the fact that it continues to work well several years after stopping the drug, and that its treatment regimen requires only two subcutaneous injections per month. In all these aspects it crushes the treatment effects of finasteride and minoxidil.
After I wrote the article "The best lab results chart for androgenic alopecia treatment ever seen by mankind", some people on the internet said that it was not the best results chart ever seen by mankind. I am of course talking about the overall results and not just the significance of a picture, otherwise it is nowhere near as good as the results chart given by those who sell pure herbal shampoos on the internet. However, I'm not going to defend myself at all. I said in my article "I don't make any arguments about hair loss (talk about comparable fall and Panga's Crossing)" that if any of the views in my previous articles contradict the views of others on the web, everything is subject to the views of others on the web, and in any case, you can just take the views of others without any need to seek my consent.
I am not averse to thoughtful arguments, and I hope that more and more people will really pay attention to the topic of hair loss and the industry, provided that they really pay attention, and not to use, amuse and consume this topic for the sake of profit, which will only make this topic more distorted and skewed.
Finally, I would like to thank Professor Xiao Ruiping for his reply and look forward to hearing your good news soon.
Previous Review.

More on Prof. Ruiping Xiao and the monoclonal antibody to the prolactin receptor

The best ever laboratory results of androgenetic alopecia treatment in human history

The basic facts about PRP mesodermal injections

The truth about the progress of new drug development for hair loss

Some recent thoughts and summaries on hair loss

Translated with www.DeepL.com/Translator (free version)
Click to expand...
What is mat3? It’s amazing how she confirmed that completely bald areas responded best and that even for monkeys who were balding for many years seen great results
 
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